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Eicosanoid


DATA No : XPR1502 INFORMANT : Shouzo Yamamoto

NAME : 7-[3(R),5(S)-Dihydroxy-2(R)-(3(S)-hydroxyocta-1(E),5(Z)-dienyl)cyclopentan-1(R)-yl]-5(Z)-heptenoic acid / (5Z,8R,9S,11R,12R,13E,15S,17Z)-9,11,15-Trihydroxyprosta-5,13,17-trienoic acid

COMMON NAME: PROSTAGLANDIN F3a
SYMBOL: PGF3a
FORMULA: C20H32O5 MOL.WT (average) : 352.465


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]d-26=+29.6deg(C=0.54, TETRAHYDROFURAN) (Ref. 1114)

DENSITY:

SOLUBILITY:TETRAHYDROFURAN (Ref. 1114)
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:TRI-TMS ETHER, METHYL ESTER ; AMMONIA CI : m/e, 600(M+18), 585, 583(M+1), 510, 493, 420, 403 (Ref. 1117)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Prostaglandin F3a is found in bovine lung (Ref. 0083).
CHEMICAL SYNTHESIS
(Ref. 1114)
[Table 0001]
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0083]
AUTHOR:Speroff, L., and Ramwell, P. W.
TITLE:Prostaglandins in reproductive physiology PubMed ID:4914185
JOURNAL:Am J Obstet Gynecol.
VOL:107 PAGE : 1111-1130 (1970)
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[1114]
AUTHOR:Corey, E. J., Shirahama, H., Yamamoto, H., Terashima, S., Venkateswarlu, A., and Schaaf, T. K.
TITLE:Stereospecific total synthesis of prostaglandins E3 and F3 alpha PubMed ID:5548346
JOURNAL:J Am Chem Soc.
VOL:93 PAGE : 1490-1491 (1971)
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[1117]
AUTHOR:Smith, D. R., Weatherly, B. C., Salmon, J. A., Ubatuba, F. B., Gryglewski, R. J., and Moncada, S.
TITLE:Preparation and biochemical properties of PGH3 PubMed ID:531219
JOURNAL:Prostaglandins.
VOL:18 PAGE : 423-438 (1979)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.