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Eicosanoid


DATA No : XPR1521 INFORMANT : Shouzo Yamamoto

NAME : 8-[2(R)-(2-Carboxyethyl)-3(S),5(R)-dihydroxycyclopentan-1(R)-yl]-6-oxooctanoic acid

COMMON NAME: PROSTAGLANDIN Fa-MAJOR URINARY METABOLITE
SYMBOL: PGFa-MUM
FORMULA: C16H26O7 MOL.WT (average) : 330.373


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
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SPECTRAL DATA
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NMR SPECTRA:

MASS SPECTRA:DIMETHYL ESTER DI-TMS ETHER ; m/e 502(M+), 487, 412, 397, 325, 322, 291, 254, 241, 228, 217, 191, 179, 143 (Ref. 1062)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
When prostaglandin F2a was administered intravenously to female subjects, 5a,7a-dihydroxy-11-keto-tetranor-prosta-1,16-dioic acid was found as a major urinary metabolite (PGFa-MUM) (Ref. 0047).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0047]
AUTHOR:Granstrom, E., and Samuelsson, B.
TITLE:On the metabolism of prostaglandin F-2-alpha in female subjects PubMed ID:5125749
JOURNAL:J Biol Chem.
VOL:246 PAGE : 5254-5263 (1971)
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[1062]
AUTHOR:Granstrom, E., and Samuelsson, B.
TITLE:The structure of a urinary metabolite of prostaglandin F2a in man PubMed ID:5791928
JOURNAL:J Am Chem Soc.
VOL:91 PAGE : 3398-3400 (1969)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.