Eicosanoid

DATA No : XPR1521 INFORMANT : Shouzo Yamamoto

NAME : 8-[2(R)-(2-Carboxyethyl)-3(S),5(R)-dihydroxycyclopentan-1(R)-yl]-6-oxooctanoic acid

COMMON NAME	:	PROSTAGLANDIN Fa-MAJOR URINARY METABOLITE
SYMBOL	:	PGFa-MUM
FORMULA	:	C₁₆H₂₆O₇ MOL.WT (average) : 330.373

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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES

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SPECTRAL DATA

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NMR SPECTRA	:

MASS SPECTRA	:	DIMETHYL ESTER DI-TMS ETHER ; m/e 502(M⁺), 487, 412, 397, 325, 322, 291, 254, 241, 228, 217, 191, 179, 143 (Ref. 1062)

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CHROMATOGRAM DATA

SOURCE

When prostaglandin F2a was administered intravenously to female subjects, 5a,7a-dihydroxy-11-keto-tetranor-prosta-1,16-dioic acid was found as a major urinary metabolite (PGFa-MUM) (Ref. 0047).

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[0047]

AUTHOR	:	Granstrom, E., and Samuelsson, B.
TITLE	:	On the metabolism of prostaglandin F-2-alpha in female subjects PubMed ID:5125749
JOURNAL	:	J Biol Chem.
VOL	:	246 PAGE : 5254-5263 (1971)

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[1062]

AUTHOR	:	Granstrom, E., and Samuelsson, B.
TITLE	:	The structure of a urinary metabolite of prostaglandin F2a in man PubMed ID:5791928
JOURNAL	:	J Am Chem Soc.
VOL	:	91 PAGE : 3398-3400 (1969)

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