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Eicosanoid

DATA No : XPR1726 INFORMANT : Takehiko Yokomizo
NAME : 11-oxo-15S-hydroxy-prosta-5Z,9,12E-trien-1-oic acid
COMMON NAME: D12-Prostaglandin J2
SYMBOL:
FORMULA: C20H30O4 MOL.WT (average) : 334.450

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BIOLOGICAL ACTIVITY
D12-PGJ2 has antitumor and antibiral activity, inhibiting growth of cultured L1210 cells with an IC50 of 0.7 mg/ml.(Ref. 2033)
PHYSICAL AND CHEMICAL PROPERTIES
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CHROMATOGRAM DATA

SOURCE
D12-PGJ2 is a decomposition product of PGD2 in the presence of albumin.(Ref. 2032)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

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REFERENCES
[2032]
AUTHOR:Fitzpatrick,F.A. and Wynalda,M.A.
TITLE:Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. PubMed ID:6578214
JOURNAL:J.Biol.Chem.
VOL:258 PAGE : 11713 -11718 (1983)
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[2033]
AUTHOR:Kato,T.,Fukushima,M.,Kurozumi,S.
TITLE:Antitumor activity of D7-prostaglandin A1 and D12-prostaglandin J2 in vitro and in vivo. PubMed ID:3708585
JOURNAL:Cancer Res.
VOL:46 PAGE : 3538 -3542 (1986)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.