Eicosanoid

DATA No : XPR1788 INFORMANT : Takehiko Yokomizo

NAME : 9a,11a,15S-trihydroxy-(8b)-prosta-5Z,13E-dien-1-oic acid

COMMON NAME	:	8-iso Prostaglandin F2a
SYMBOL	:
FORMULA	:	C₂₀H₃₄O₅ MOL.WT (average) : 354.481

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BIOLOGICAL ACTIVITY

8-iso PGF2a is reported to inhibit platelet aggregation induced by U-46619 (1 mM) and I-BOP (0.3 mM) with IC50 of 1.6 mM and 1.8 mM, respectively.(Ref. 2094)

PHYSICAL AND CHEMICAL PROPERTIES

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SOURCE

In normal human urine, 8-iso PGF2a level are about 180-200 pg/mg of creatinine.(Ref. 2095)

CHEMICAL SYNTHESIS

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GENETIC INFORMATION

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REFERENCES

[2094]

AUTHOR	:	Morrow, J. D., Minton, T. A., and Roberts, L. J., 2nd
TITLE	:	The F2-isoprostane, 8-epi-prostaglandin F2 alpha, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist PubMed ID:1438879
JOURNAL	:	Prostaglandins.
VOL	:	44 PAGE : 155-163 (1992)

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[2095]

AUTHOR	:	Morrow, J. D., Harris, T. M., and Roberts, L. J., 2nd
TITLE	:	Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids PubMed ID:2321745
JOURNAL	:	Anal Biochem.
VOL	:	184 PAGE : 1-10 (1990)

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