Eicosanoid

DATA No : XPR1798 INFORMANT : Takehiko Yokomizo

NAME : 9a,11a-epidioxy-15S-hydroxy-prosta-5Z,13E-dien-1-oic acid

COMMON NAME	:	Prostaglandin H2
SYMBOL	:
FORMULA	:	C₂₀H₃₂O₅ MOL.WT (average) : 352.465

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BIOLOGICAL ACTIVITY

PGH2 was firstly reported as a potent vasoconstrictor.(Ref. 2106) And PGH2 has been reported as a TP receptor agonist which irreversibly aggregates huma platelets at 50-100 ng/ml and also as a suicide substrate for platelet TX synthase prosessing a Ki value of 18 mM .(Ref. 2107)

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CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

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REFERENCES

[2106]

AUTHOR	:	Hamberg, M., Svensson, J., Wakabayashi, T.
TITLE	:	Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. PubMed ID:4521806
JOURNAL	:	Proc. Natl. Acad. Sci. USA
VOL	:	71 PAGE : 345 -349 (1974)

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[2107]

AUTHOR	:	Jones, D. A., Fitzpatrick, F. A.
TITLE	:	""Suicide"" inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets. PubMed ID:2243085
JOURNAL	:	J. Biol. Chem.
VOL	:	265 PAGE : 20166 -20171 (1990)

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