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Eicosanoid


DATA No : XPR1798 INFORMANT : Takehiko Yokomizo

NAME : 9a,11a-epidioxy-15S-hydroxy-prosta-5Z,13E-dien-1-oic acid

COMMON NAME: Prostaglandin H2
SYMBOL:
FORMULA: C20H32O5 MOL.WT (average) : 352.465


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BIOLOGICAL ACTIVITY
PGH2 was firstly reported as a potent vasoconstrictor.(Ref. 2106) And PGH2 has been reported as a TP receptor agonist which irreversibly aggregates huma platelets at 50-100 ng/ml and also as a suicide substrate for platelet TX synthase prosessing a Ki value of 18 mM .(Ref. 2107)
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REFERENCES
[2106]
AUTHOR:Hamberg, M., Svensson, J., Wakabayashi, T.
TITLE:Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. PubMed ID:4521806
JOURNAL:Proc. Natl. Acad. Sci. USA
VOL:71 PAGE : 345 -349 (1974)
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[2107]
AUTHOR:Jones, D. A., Fitzpatrick, F. A.
TITLE:""Suicide"" inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets. PubMed ID:2243085
JOURNAL:J. Biol. Chem.
VOL:265 PAGE : 20166 -20171 (1990)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.