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COMMON NAME | : | LEUKOTRIENE B4 |
SYMBOL | : | LTB4 |
FORMULA | : | C20H32O4 MOL.WT (average) : 336.466 |
BIOLOGICAL ACTIVITY |
PHYSICAL AND CHEMICAL PROPERTIES |
MELTING POINT | : | |
BOILING POINT | : | |
REFRACTIVE INDEX | : | |
OPTICAL ROTATION | : | |
DENSITY | : | |
SOLUBILITY | : | METHANOL (Ref. 1021) |
SPECTRAL DATA |
UV SPECTRA | : | METHANOL : 260(e 38,000), 270.5(e 50,000), 281(e 39,000)nm (Ref. 1021) |
IR SPECTRA | : | |
NMR SPECTRA | : | 1H-NMR(250MHz, D2O) : d 6.45(m, 1H, 8-CH), 6.15(m, 2H, 9,10-CH), 6.0(m, 1H, 7-CH), 5.65(m, 1H, 11-CH), 5.40(m, 1H, 15-CH), 5.25(m, 2H, 6,14-CH), 4.60(5-CH), 4.05(m, 1H, 12-CH), 2.15(m, 2H, 13-CH), 2.00(m, 1H, 2-CH), 1.85(m, 2H, 16-CH), 1.35-1.60(m, 4H, 3,4-CH), 1.00-1.25(m, 6H, 17,18,19-CH), 0.70(m, 3H, 20-CH) (Ref. 1022) |
MASS SPECTRA | : | m/e 336, 319, 301 (Ref. 1023) |
OTHER SPECTRA | : | |
CHROMATOGRAM DATA |
SOURCE |
CHEMICAL SYNTHESIS |
METABOLISM |
GENETIC INFORMATION |
NOTE |
REFERENCES |
AUTHOR | : | Funk, C.D. |
TITLE | : | Molecular biology in the eicosanoid field . PubMed ID:8341804 |
JOURNAL | : | Progr. Nucleic Acid Res. |
VOL | : | 45 PAGE : 67 -98 (1993) |
AUTHOR | : | Samuelsson, B., and Hammarstrom, S. |
TITLE | : | Leukotrienes: a novel group of biologically active compounds PubMed ID:6293196 |
JOURNAL | : | Vitam Horm. |
VOL | : | 39 PAGE : 1-30 (1982) |
AUTHOR | : | Hammarstrom, S. |
TITLE | : | Leukotrienes PubMed ID:6311078 |
JOURNAL | : | Annu Rev Biochem. |
VOL | : | 52 PAGE : 355-377 (1983) |
AUTHOR | : | Sumimoto, H., Takeshige, K., and Minakami, S. |
TITLE | : | Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4 PubMed ID:6322859 |
JOURNAL | : | Biochim Biophys Acta. |
VOL | : | 803 PAGE : 271-277 (1984) |
AUTHOR | : | Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., and Shimizu, T. |
TITLE | : | A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis PubMed ID:9177352 |
JOURNAL | : | Nature. |
VOL | : | 387 PAGE : 620-624 (1997) |
AUTHOR | : | Ford-Hutchinson, A. W., Gresser, M., and Young, R. N. |
TITLE | : | 5-Lipoxygenase PubMed ID:7979243 |
JOURNAL | : | Annu Rev Biochem. |
VOL | : | 63 PAGE : 383-417 (1994) |
AUTHOR | : | Yokomizo,T., Izumi,T., Takahashi,T., Kazama,T., Kobayashi,Y., Sato,F., Taketani,Y., and Shimizu,T. |
TITLE | : | Enzymatic inactivation of leukotrieneB4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. PubMed ID:8394361 |
JOURNAL | : | J. Biol. Chem. |
VOL | : | 268 PAGE : 18128 -18135 (1993) |
AUTHOR | : | Yokomizo,T., Ogawa,Y., Uozumi,N., Kume,K., Izumi,T., Shimizu,T. |
TITLE | : | cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. PubMed ID:8576264 |
JOURNAL | : | J. Biol. Chem. |
VOL | : | 271 PAGE : 2844 -2850 (1996) |
AUTHOR | : | Corey,E.J., Marfat,A., Goto,G., and Brion F. |
TITLE | : | Leukotriene B. Total Synthesis and Assignment of Stereochemistry. |
JOURNAL | : | J. Am. Chem. Soc. |
VOL | : | 102 PAGE : 7984 -7985 (1980) |
AUTHOR | : | Merrer,Y.L., Gravier-Pelletier,C., Micas-Languin,D., Mestre,F., Durö$ault,A., and Depezay,J.-C. |
TITLE | : | Total Synthesis of Leukotriene B4 [(+)-LTB4] and Homo-LTB4 from D-Mannitol. |
JOURNAL | : | J. Org. Chem. |
VOL | : | 54 PAGE : 2409 -2416 (1989) |
AUTHOR | : | Yergey, J. A., Kim, H. Y., and Salem, N., Jr. |
TITLE | : | High-performance liquid chromatography/thermospray mass spectrometry of eicosanoids and novel oxygenated metabolites of docosahexaenoic acid PubMed ID:2942056 |
JOURNAL | : | Anal Chem. |
VOL | : | 58 PAGE : 1344-1348 (1986) |