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Eicosanoid


DATA No : XPR3112 INFORMANT : Takao Shimizu

NAME : 5S-hydroxy-12R-keto-[6Z, 8E]-eicosatedienoic acid

COMMON NAME: 10,11,14,15-tetrahydro-12-keto-Leukotriene B4
SYMBOL: 10,11,14,15-tetrahydro-12-keto-LTB4
FORMULA: C20H34O4 MOL.WT (average) : 338.482


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BIOLOGICAL ACTIVITY
unknown
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

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OPTICAL ROTATION:

DENSITY:

SOLUBILITY:Soluble in ethanol, methanol, ethyl acetate, acetonitril
SPECTRAL DATA
UV SPECTRA:UV maxima 235 nm, Absorbance at 320 nm is 30500/M

IR SPECTRA:

NMR SPECTRA:

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OTHER SPECTRA:
CHROMATOGRAM DATA
10, 11, 14, 15-tetrahydro-12-oxo-LTB4 is eluted at 12.6min on RP-HPLC system as follows: Solvent:acetonitril/water/acetic acid, 50:50:0.01 (v/v/v), 0.01 % (w/v) Na2EDTA, pH 5.6 with ammonia Flow: 1 ml/min, isocratic Column: Cosmosil 5C18-AR (4.6 x 150 mm, Nacalai tesque, Tokyo) (Ref. 3111)
SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[3111]
AUTHOR:Yokomizo, T.,Izumi, T., Takahashi, T., Kasama, T., Kobayashi, Y., Sato, F., Taketani, Y., Shimizu, T.
TITLE:Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12- hydroxydehydrogenase. PubMed ID:8394361
JOURNAL:J. Biol. Chem.
VOL:268 PAGE : 18128 -18135 (1993)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.