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Eicosanoid

DATA No : XPR3118 INFORMANT : Takehiko Yokomizo
NAME : 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraene-1,20-dioic acid
COMMON NAME: 20-carboxy Leukotriene B4
SYMBOL:
FORMULA: C20H30O6 MOL.WT (average) : 366.449

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BIOLOGICAL ACTIVITY
The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degradation.(Ref. 2130)
PHYSICAL AND CHEMICAL PROPERTIES
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CHROMATOGRAM DATA

SOURCE
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

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REFERENCES
[2130]
AUTHOR:Feinmark, S. J., Lindgren, J. A., Claesson, H. E., Malmsten, C., and Samuelsson, B.
TITLE:Stimulation of human leukocyte degranulation by leukotriene B4 and its omega-oxidized metabolites PubMed ID:6274698
JOURNAL:FEBS Lett.
VOL:136 PAGE : 141-144 (1981)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.