Eicosanoid

DATA No : XPR3120 INFORMANT : Takehiko Yokomizo

NAME : 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid

COMMON NAME	:	20-hydroxy Leukotriene B4
SYMBOL	:
FORMULA	:	C₂₀H₃₂O₅ MOL.WT (average) : 352.465

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BIOLOGICAL ACTIVITY

20-hydroxy LTB4 is commonly accepted as a inactive metabolite of LTB4 but reported to contract parenchymal strips from guinea pig lung (Ref. 2129) and as a good ligand form BLT2 receptor.(Ref. 2128)

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REFERENCES

[2128]

AUTHOR	:	Yokomizo, T., Kato, K., Hagiya, H., Izumi, T., and Shimizu, T.
TITLE	:	Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2 PubMed ID:11278893
JOURNAL	:	J Biol Chem.
VOL	:	276 PAGE : 12454-12459 (2001)

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[2129]

AUTHOR	:	Hansson, G., Lindgren, J. A., Dahlen, S. E., Hedqvist, P., and Samuelsson, B.
TITLE	:	Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes PubMed ID:6793392
JOURNAL	:	FEBS Lett.
VOL	:	130 PAGE : 107-112 (1981)

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