Eicosanoid

DATA No : XPR3501 INFORMANT : Shouzo Yamamoto

NAME : 5(S)-Hydroxy-6(R)-S-glutamylcysteinyleicosa-7(E),9(E),11(Z),14(Z)-tetraenoic acid

BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES

SPECTRAL DATA

UV SPECTRA	:	l = 270sh, 280(e 40000), 290sh nm (Ref. 1064)

IR SPECTRA	:	N-TRIFLUOROACETYL METHYL ESTER ; n 3300, 1720, 1650, 1200, 985cm^-¹ (Ref. 1065)

NMR SPECTRA	:	N-TRIFLUOROACETYL METHYL ESTER ; ¹H-NMR(CDCl₃) : d 6.9-5.2(m, 8H), 5.0-4.5(m, 2H), 3.8-3.6(m, 1H, 5-CH), 3.79(s, 3H, OCH₃), 3.76(s, 3H, OCH₃), 3.67(s, 3H, OCH₃), 3.6-3.3(m, 1H, 6-CH), 3.1-2.7(m, 4H), 0.9(t, J=7Hz, 3H, 20-CH₃) (Ref. 1065)

MASS SPECTRA	:	N-TRIFLUOROACETYL METHYL ESTER ; 701(M⁺), 688, 675, 674, 662, 657, 649, 648, 578, 550, 465 (Ref. 1065)

OTHER SPECTRA	:

CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

(Ref. 1066)
[Table 0001]

METABOLISM

Leukotriene E4 is transformed to leukotriene F4 by g-glultamyltransferase in the presence of glutathione (Ref. 0052).

GENETIC INFORMATION

NOTE

REFERENCES

[0052]

AUTHOR	:	Hammarstrom,S., Oerning,L., and Bernstroem,K.
TITLE	:	Metabolism of leukotrienes. PubMed ID:3001504
JOURNAL	:	Molecular and Cellular Biochemistry
VOL	:	69 PAGE : 7 -16 (1985)

[1064]

AUTHOR	:	Denis, D., Charleson, S., Rackham, A., Jones, T. R., Ford-Hutchinson, A. W., Lord, A., Cirino, M., Girard, Y., Larue, M., and Rokach, J.
TITLE	:	Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone PubMed ID:6300970
JOURNAL	:	Prostaglandins.
VOL	:	24 PAGE : 801-814 (1982)

[1065]

AUTHOR	:	Okuyama, S., Miyamoto, S., Shimoji, K., Konishi, Y., Fukushima, D., Niwa, H., Arai, Y., Toda, M., and Hayashi, M.
TITLE	:	Structural analogs of leukotrienes C and D avd their contractile activities PubMed ID:7139817
JOURNAL	:	Chem Pharm Bull (Tokyo).
VOL	:	30 PAGE : 2453-2462 (1982)

[1066]

AUTHOR	:	Ellis,F., Mills,L.S., and North,P.C.
TITLE	:	A Total Synthesis of Leukotriene F4 (LTF4).
JOURNAL	:	Tetrah. Lett.
VOL	:	23 PAGE : 3735 -3736 (1982)