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Eicosanoid


DATA No : XPR6014 INFORMANT : Shouzo Yamamoto

NAME : (R),(Z,E,Z,Z)-8-Hydroperoxy-5,9,11,14-eicosatetraenoic acid

COMMON NAME:
SYMBOL: 8(R)-HPETE
FORMULA: C20H32O4 MOL.WT (average) : 336.466


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:ETHYL ACETATE , METHANOL (Ref. 1092)
SPECTRAL DATA
UV SPECTRA:l max = 235.8nm (e 28,000) (Ref. 1092)

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
The compound is produced by the catalysis of 8(R)-lipoxygenase as an intermediate of coral prostanoid biosynthesis (Ref. 0073).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0073]
AUTHOR:Brash,A.R., Baertschi,S.W., Ingram,C.D., and Harris,T.M.
TITLE:On non-cyclooxygenase prostaglandin synthesis in the sea whip coral, Plexaura homomalla: an 8(R)-lipoxygenase pathway leads to formation of an a-ketol and a racemic prostanoid. PubMed ID:2824470
JOURNAL:J. Biol. Chem.
VOL:262 PAGE : 15829 -15839 (1987)
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[1092]
AUTHOR:Bundy, G. L., Nidy, E. G., Epps, D. E., Mizsak, S. A., and Wnuk, R. J.
TITLE:Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa PubMed ID:2867091
JOURNAL:J Biol Chem.
VOL:261 PAGE : 747-751 (1986)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.