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| =Biosynthesis of Glycerophospholipid=
| | {| style="text-align:left; margin:auto;" |
| | | | [[Image:Arrow3ldl.png]] |
| | | |style="white-space:nowrap"|<small>{{{1|}}}</small><br/>{{{3|}}}<br/><small>{{{2|}}}</small> |
| | |
| {| | |
| |-
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| |
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| |style="text-align:center"|CDP-diacyl glycerol<br/>CDP-DG({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBCDPDG.png|105px]] | |
| |style="text-align:center"|EC2.7.8.11<br/>[[Image:arrowr.png|100px]]<br/>↑Inositol ↓CMP
| |
| |style="text-align:center"|phosphatidyl inositol<br/>PI({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBGPI.png|105px]]
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| |-
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| |style="text-align:center;vertical-align:bottom"|ethanolamine<br/>[[Image:LBE.png|85px]]
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| |
| |
| {| style="float:right"
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| |-
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| |[[Image:arrow2ub.png|6px]]
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| |
| |
| {|
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| |-
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| |→ PPi | |
| |-
| |
| |EC 2.7.7.41
| |
| |-
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| |→ CTP
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| |}
| |
| |}
| |
| |-
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| |style="text-align:center;vertical-align:top"|[[Image:Arrow00_d.png|50px]]<br/>O-phospho<br/>ethanolamine<br/>[[Image:LBOPE.png|85px]]
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| |style="text-align:center"|phosphatidate<br/>PA({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBGPA.png|90px]] | |
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| |
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| |style="text-align:center"|choline<br/>[[Image:LBC.png|95px]]<br/>[[Image:Arrow00_d.png|50px]]
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| |-
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| |style="text-align:center"|[[Image:Arrow00_d.png|50px]]<br/>CDP-ethanolamine<br/>[[Image:LBCDPE.png|120px]]
| |
| |style="text-align:center"|
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| {|
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| |
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| {| style="text-align:right"
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| |-
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| |ADP ←
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| |-
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| |EC 2.7.1.107
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| |-
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| |ATP →
| |
| |}
| |
| |[[Image:Arrowu.png|6px]]
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| |[[Image:Arrow00_d.png|50px]]
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| |
| |
| {|
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| |-
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| |→ H2O
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| |-
| |
| |EC 3.1.3.4
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| |-
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| |→ Pi
| |
| |}
| |
| |}
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| |style="text-align:center"|CDP-choline<br/>[[Image:LBCDPC.png|125px]]
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| |style="text-align:center"|[[Image:arrowl.png|45px]]
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| |style="text-align:center"|O-phospho choline<br/>[[Image:LBOPC.png|95px]]
| |
| |-
| |
| |
| |
| {| | |
| |EC 2.7.8.1<br/>CMP←
| |
| |[[Image:Arrowbmbl.png|140px]]
| |
| |}
| |
| |style="text-align:center"|diacyl glycerol<br/>DG({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBDG.png|90px]]
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| |
| |
| {|
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| |[[Image:Arrowbmbr.png|140px]]
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| |EC 2.7.8.2<br/>→CMP
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| |}
| |
| |-
| |
| |style="text-align:center"|
| |
| {| | |
| |-
| |
| |phosphatidyl<br/>ethanolamine
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| |{{Map/Glycerophospholipid/GetValues|head=PE|R1={{#get:R1}}|R2={{#get:R2}}}}
| |
| |} | |
| PE({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBGPE.png|140px]]
| |
| |style="text-align:center"|EC2.1.1.17 <br/>
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| [[Image:arrowr.png|40px]][[Image:arrowr.png|40px]][[Image:arrowr.png|40px]]<br/>3step methylation<br/>
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| ↓ 3SAM ↓ 3SAH
| |
| |style="text-align:center"|
| |
| {|
| |
| |-
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| |phosphatidyl<br/>choline<br/>(or lecithin)
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| |{{Map/Glycerophospholipid/GetValues|head=PC|R1={{#get:R1}}|R2={{#get:R2}}}}
| |
| |}
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| PC({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBGPC.png|160px]]
| |
| |-
| |
| |
| |
| {| style="text-align:right" | |
| | decarboxylation
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| |[[Image:arrowu.png|6px]]
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| |[[Image:Arrow00_d.png|50px]]
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| |
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| {| style="text-align:left"
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| |← Ser
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| |-
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| |
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| |-
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| |→ ethanolamine
| |
| |}
| |
| |}
| |
| |colspan="4" rowspan="3"|
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| {| class="wikitable"
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| ! style="text-align:center"| Structure Specification
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| |-
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| <big> {{#formtag:form|action="/wiki/Template:Map/Glycerophospholipid"|
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| <!-----
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| Set the expression data for {{#formtag:select|name="GPLData"|
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| {{#formtag:option|value="P0"|Day 0}}
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| {{#formtag:option|value="P3"|Day 4}}
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| {{#formtag:option|value="P5"|Day 5}}
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| {{#formtag:option|value="P7"|Day 7}}
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| {{#formtag:option|value="P10"|Day 10}}
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| {{#formtag:option|value="P15"|Day 15}}
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| {{#formtag:option|value="P27"|Day 27}}
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| }}.---->
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| | |
| Set the R1 moiety to {{#formtag:select|name="R1"|
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| {{#formtag:option|value="-"|-}}
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| {{#formtag:option|value="12:0" {{#ifeq:{{#get:R1}}|12:0|selected="yes"}}|12:0}}
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| {{#formtag:option|value="14:0" {{#ifeq:{{#get:R1}}|14:0|selected="yes"}}|14:0}}
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| {{#formtag:option|value="16:0" {{#ifeq:{{#get:R1}}|16:0|selected="yes"}}|16:0}}
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| {{#formtag:option|value="16:1" {{#ifeq:{{#get:R1}}|16:1|selected="yes"}}|16:1}}
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| {{#formtag:option|value="18:0" {{#ifeq:{{#get:R1}}|18:0|selected="yes"}}|18:0}}
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| {{#formtag:option|value="18:1" {{#ifeq:{{#get:R1}}|18:1|selected="yes"}}|18:1}}
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| }}.
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| Set the R2 moiety to {{#formtag:select|name="R2"|
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| {{#formtag:option|value="-"|-}}
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| {{#formtag:option|value="12:0" {{#ifeq:{{#get:R2}}|12:0|selected="yes"}}|12:0}}
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| {{#formtag:option|value="14:0" {{#ifeq:{{#get:R2}}|14:0|selected="yes"}}|14:0}}
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| {{#formtag:option|value="16:0" {{#ifeq:{{#get:R2}}|16:0|selected="yes"}}|16:0}}
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| {{#formtag:option|value="18:0" {{#ifeq:{{#get:R2}}|18:0|selected="yes"}}|18:0}}
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| {{#formtag:option|value="18:1" {{#ifeq:{{#get:R2}}|18:1|selected="yes"}}|18:1}}
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| {{#formtag:option|value="18:2" {{#ifeq:{{#get:R2}}|18:2|selected="yes"}}|18:2}}
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| {{#formtag:option|value="20:0" {{#ifeq:{{#get:R2}}|20:0|selected="yes"}}|20:0}}
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| {{#formtag:option|value="20:1" {{#ifeq:{{#get:R2}}|20:1|selected="yes"}}|20:1}}
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| {{#formtag:option|value="20:2" {{#ifeq:{{#get:R2}}|20:2|selected="yes"}}|20:2}}
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| {{#formtag:option|value="20:3" {{#ifeq:{{#get:R2}}|20:3|selected="yes"}}|20:3}}
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| {{#formtag:option|value="20:4" {{#ifeq:{{#get:R2}}|20:4|selected="yes"}}|20:4}}
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| {{#formtag:option|value="22:0" {{#ifeq:{{#get:R2}}|22:0|selected="yes"}}|22:0}}
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| {{#formtag:option|value="22:1" {{#ifeq:{{#get:R2}}|22:1|selected="yes"}}|22:1}}
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| {{#formtag:option|value="22:2" {{#ifeq:{{#get:R2}}|22:2|selected="yes"}}|22:2}}
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| {{#formtag:option|value="22:3" {{#ifeq:{{#get:R2}}|22:3|selected="yes"}}|22:3}}
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| {{#formtag:option|value="22:4" {{#ifeq:{{#get:R2}}|22:4|selected="yes"}}|22:4}}
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| {{#formtag:option|value="22:5" {{#ifeq:{{#get:R2}}|22:5|selected="yes"}}|22:5}}
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| {{#formtag:option|value="22:6" {{#ifeq:{{#get:R2}}|22:6|selected="yes"}}|22:6}}
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| }}. {{#formtag:input|type="submit"}}
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| }}</big>
| |
| |}
| |
| | |
| |-
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| |style="text-align:center"|
| |
| {|
| |
| |-
| |
| |phosphatidyl<br/>serine
| |
| |{{Map/Glycerophospholipid/GetValues|head=PS|R1={{#get:R1}}|R2={{#get:R2}}}}
| |
| |}
| |
| PS({{#get:R1}}/{{#get:R2}})<br/>[[Image:LBGPS.png|150px]]
| |
| |} | | |} |