Category:LBS/Biosynthesis/CeramideDeg: Difference between revisions
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|style="background:AntiqueWhite;border-radius: 20px 0px 0px 0px" | | |style="background:AntiqueWhite;border-radius: 20px 0px 0px 0px" | ceramide | ||
|style="background:AntiqueWhite" | <small>ceramidase</small><br/>[[File: | |style="background:AntiqueWhite" | <small>ceramidase</small><br/>[[File:Arrow2rr.png]]<br/><small> fatty acid</small> | ||
|style="background:AntiqueWhite" | | |style="background:AntiqueWhite" | sphingosine | ||
|style="background:AntiqueWhite" | | |style="background:AntiqueWhite" | <small>S1P phosphatase</small><br/>[[File:Arrow00h.png]]<br/> <small></small> | ||
|style="background:AntiqueWhite" | | |style="background:AntiqueWhite" | sphingosine<br/> 1-phosphate | ||
|style="background:AntiqueWhite" | | |style="background:AntiqueWhite" | <small>S1P lyase</small><br/>[[File:Arrow2rr.png]]<br/> <small>phosphoethanolamine</small> | ||
|style="background:AntiqueWhite" | | |style="background:AntiqueWhite" | hexadecenal | ||
|style="background:AntiqueWhite" | <br/>[[File: | |style="background:AntiqueWhite" | <br/>[[File:Arrow00r35.png]]<br/> <small></small> | ||
|style="background:AntiqueWhite" | | |style="background:AntiqueWhite" | hexadecanal | ||
|style="background:AntiqueWhite" | <br/>[[File: | |style="background:AntiqueWhite" | <br/>[[File:Arrow00r35.png]]<br/> <small></small> | ||
|style="background:AntiqueWhite;border-radius: 0px 20px 0px 0px" | | |style="background:AntiqueWhite;border-radius: 0px 20px 0px 0px" | palmitate | ||
|- | |- | ||
|colspan="11" style="background:AntiqueWhite;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: black;"| <big> | |colspan="11" style="background:AntiqueWhite;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: black;"| <big>ER, Golgi and Lysosomes</big> | ||
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{| class="wikitable collapsible collapsed" style="width: 100%" | |||
!colspan="4"| Enzyme function in the Human Genome | |||
|- | |||
! Protein name | |||
! Gene name (Uniprot) | |||
! Location | |||
! | |||
|- | |||
| Acid ceramidase | |||
| [http://www.uniprot.org/uniprot/Q13510 ASAH1] | |||
| 8p22 | |||
| Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).<ref>Ferlinz K, Kopal G, Bernardo K et al. (2001) "Human acid ceramidase: processing, glycosylation, and lysosomal targeting" J Biol Chem 276(38):35352-35360.</ref> | |||
|- | |||
| Neutral ceramidase | |||
| [http://www.uniprot.org/uniprot/Q9NR71 ASAH2] | |||
| 10q11.23 | |||
| Localized to the plasma membrane and expressed in the small intestine and colon. <ref>Coant N, Sakamoto W, Mao C, Hannun YA (2015) "Ceramidases, roles in sphingolipid metabolism and in health and disease" Adv Biol Regul 63:122-131</ref> | |||
|- | |||
|rowspan="3"| Alkaline ceramidase | |||
| [http://www.uniprot.org/uniprot/Q8TDN7 ACER1](ASAH3) | |||
| 19p13.3 | |||
| Localized to the endoplasmic reticulum (ER) and highly expressed in skin. | |||
|- | |||
| [http://www.uniprot.org/uniprot/Q5QJU3 ACER2](ASAH3L) | |||
| 9p22.1 | |||
| Localized to the Golgi complex and highly expressed in placenta. | |||
|- | |||
| [http://www.uniprot.org/uniprot/Q9NUN7 ACER3](APHC) | |||
| 11q13.5 | |||
| Localized to the ER and the Golgi complex, and ubiquitously expressed. | |||
|- | |||
| rowspan="2"| S1P phosphatase | |||
| [http://www.uniprot.org/uniprot/Q9BX95 SGPP1] | |||
| 14q23.2 | |||
| Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. | |||
|- | |||
| [http://www.uniprot.org/uniprot/Q8IWX5 SGPP2] | |||
| 2q36.1 | |||
| Localized to the ER and dephosphorylates S1P and dihydro-S1P.<ref>Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003) "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2" J Biol Chem 278(2):1268-1272.</ref> | |||
|- | |||
| S1P lyase | |||
| [http://www.uniprot.org/uniprot/O95470 SGPL1] | |||
| 10q22.1 | |||
| | |||
|- | |||
|colspan="4"|<references/> | |||
|} | |} | ||
Latest revision as of 06:32, 18 December 2017
| ceramide | ceramidase fatty acid |
sphingosine | S1P phosphatase |
sphingosine 1-phosphate |
S1P lyase phosphoethanolamine |
hexadecenal |  |
hexadecanal | |
palmitate |
| ER, Golgi and Lysosomes | ||||||||||
| Enzyme function in the Human Genome | |||
|---|---|---|---|
| Protein name | Gene name (Uniprot) | Location | |
| Acid ceramidase | ASAH1 | 8p22 | Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).[1] |
| Neutral ceramidase | ASAH2 | 10q11.23 | Localized to the plasma membrane and expressed in the small intestine and colon. [2] |
| Alkaline ceramidase | ACER1(ASAH3) | 19p13.3 | Localized to the endoplasmic reticulum (ER) and highly expressed in skin. |
| ACER2(ASAH3L) | 9p22.1 | Localized to the Golgi complex and highly expressed in placenta. | |
| ACER3(APHC) | 11q13.5 | Localized to the ER and the Golgi complex, and ubiquitously expressed. | |
| S1P phosphatase | SGPP1 | 14q23.2 | Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. |
| SGPP2 | 2q36.1 | Localized to the ER and dephosphorylates S1P and dihydro-S1P.[3] | |
| S1P lyase | SGPL1 | 10q22.1 | |
| |||
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