Category:LBS/Biosynthesis/CeramideDeg: Difference between revisions

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| Acid ceramidase
| Acid ceramidase
| ASAH1
| [http://www.uniprot.org/uniprot/Q13510 ASAH1]
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| 8p22
| Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).<ref>Ferlinz K, Kopal G, Bernardo K et al. (2001) "Human acid ceramidase: processing, glycosylation, and lysosomal targeting" J Biol Chem 276(38):35352-35360.</ref>
| Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).<ref>Ferlinz K, Kopal G, Bernardo K et al. (2001) "Human acid ceramidase: processing, glycosylation, and lysosomal targeting" J Biol Chem 276(38):35352-35360.</ref>
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| Neutral ceramidase
| Neutral ceramidase
| ASAH2
| [http://www.uniprot.org/uniprot/Q9NR71 ASAH2]
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| 10q11.23
| Localized to the plasma membrane and expressed in the small intestine and colon. <ref>Coant N, Sakamoto W, Mao C, Hannun YA (2015) "Ceramidases, roles in sphingolipid metabolism and in health and disease" Adv Biol Regul 63:122-131</ref>
| Localized to the plasma membrane and expressed in the small intestine and colon. <ref>Coant N, Sakamoto W, Mao C, Hannun YA (2015) "Ceramidases, roles in sphingolipid metabolism and in health and disease" Adv Biol Regul 63:122-131</ref>
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|rowspan="3"| Alkaline ceramidase
|rowspan="3"| Alkaline ceramidase
| ACER1
| [http://www.uniprot.org/uniprot/Q8TDN7 ACER1](ASAH3)
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| 19p13.3
| Localized to the endoplasmic reticulum (ER) and highly expressed in skin.
| Localized to the endoplasmic reticulum (ER) and highly expressed in skin.
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| ACER2
| [http://www.uniprot.org/uniprot/Q5QJU3 ACER2](ASAH3L)
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| 9p22.1
| Localized to the Golgi complex and highly expressed in placenta.
| Localized to the Golgi complex and highly expressed in placenta.
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| ACER3
| [http://www.uniprot.org/uniprot/Q9NUN7 ACER3](APHC)
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| 11q13.5
| Localized to the ER and the Golgi complex, and ubiquitously expressed.
| Localized to the ER and the Golgi complex, and ubiquitously expressed.
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| rowspan="2"| S1P phosphatase
| rowspan="2"| S1P phosphatase
| SGPP1
| [http://www.uniprot.org/uniprot/Q9BX95 SGPP1]
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| 14q23.2
| Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P.  
| Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P.  
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| SGPP2
| [http://www.uniprot.org/uniprot/Q8IWX5 SGPP2]
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| 2q36.1
| Localized to the ER and dephosphorylates S1P and dihydro-S1P.<ref>Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003) "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2" J Biol Chem 278(2):1268-1272.</ref>
| Localized to the ER and dephosphorylates S1P and dihydro-S1P.<ref>Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003) "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2" J Biol Chem 278(2):1268-1272.</ref>
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| S1P lyase
| S1P lyase
| SGPL1
| [http://www.uniprot.org/uniprot/O95470 SGPL1]
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| 10q22.1
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|colspan="4"|<references/>
|colspan="4"|<references/>
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Latest revision as of 06:32, 18 December 2017

ceramide  ceramidase
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   fatty acid
sphingosine S1P phosphatase
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sphingosine
1-phosphate
S1P lyase
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  phosphoethanolamine
hexadecenal  
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hexadecanal  
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palmitate
ER, Golgi and Lysosomes

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