Category:LBS/Biosynthesis/CeramideDeg: Difference between revisions
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Revision as of 00:12, 18 December 2017
| ceramide | ceramidase fatty acid |
sphingosine | S1P phosphatase |
sphingosine 1-phosphate |
S1P lyase phosphoethanolamine |
hexadecenal |  |
hexadecanal | |
palmitate |
| ER, Golgi and Lysosomes | ||||||||||
| Enzyme function in the Human Genome | |||
|---|---|---|---|
| Protein name | Gene name (Uniprot) | Location | |
| Acid ceramidase | ASAH1 | Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).[1] | |
| Neutral ceramidase | ASAH2 | Localized to the plasma membrane and expressed in the small intestine and colon. [2] | |
| Alkaline ceramidase | ACER1 | Localized to the endoplasmic reticulum (ER) and highly expressed in skin. | |
| ACER2 | Localized to the Golgi complex and highly expressed in placenta. | ||
| ACER3 | Localized to the ER and the Golgi complex, and ubiquitously expressed. | ||
| S1P phosphatase | SGPP1 | Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. | |
| SGPP2 | Localized to the ER and dephosphorylates S1P and dihydro-S1P.[3] | ||
| S1P lyase | SGPL1 | ||
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