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| No | Structure | COMMON NAME | NAME | DATA No | INFORMANT | SYMBOL | FORMULA | MOL.WT(ave) | Download | BIOOGICAL ACTIVITY | PHYSICAL AND CHEMICAL PROPERTIES | SPECTRAL DATA | CHROMATOGRAM DATA | SOURCE | CHEMICAL SYNTHESIS | METABOLISM | GENETIC INFORMATION | NOTE | REFERENCES | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MELTING POINT | BOILING POINT | DENSITY | REFRACTIVE INDEX | OPTICAL ROTATION | SOLUBILITY | UV SPECTRA | IR SPECTRA | NMR SPECTRA | MASS SPECTRA | OTHER SPECTRA | ||||||||||||||||||
| 1 |  |
RRR-a-tocopherol d-a-tocopherol |
2R-(4'R,8'R,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0001 | Fumiko Hirahara |
RRR-a-Toc/d-a-Toc |
C29H50O2 | 430.706 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. RRR-a-tocopherol has been reported as 135-194% more than all-rac-a-tocopherol when evaluated by the rat resorption-gestation test , about 200% in terms of tissue retention of deuterated tocopherols in rat and human. The relationship between a-tocopherol and its derivatives was announced by USP. [Table 0008] [Table 0009] RRR-a-tocopherol has been assigned an activity of 1 mg a-TE per mg. [Table 0010] (Ref. 0034/0035/0036) |
a  in ethanol/d in benzene (Ref. 0001) |
practically insol in water , freely sol in acetone, in ethanol, in ether, in methylene chloride and in fatty oils (Ref. 0002) |
292nm, E1%1cm=75.8(ethanol) |
3310,2930,1620,1590,1460,1375,1270,1160,850cm-1 |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
1.High linoleic acid type margarine 2.Sunflower oil 3.Cottonseed oil 4.Wheat germ 5.Roasted and salted sweet almond 6.Safflower oil 7.Rice bran oil 8.Roasted hazelnuts 9.Dried sunflower seeds 10.Anglerfish liver 11.Roasted Pine nuts 12.Virginia type dried peanuts 13.Spanish type dried peanuts 14.Salted roe 15.Uncooked and salted pollack roe 16.Palm oil 17.Cultured fish 18.Olive oil 19.Fried potato chips 20.Black karinto 21.Age-senbei 22.Raw roe (Ref. 0003/0004/0005/0006/0007/0033/0034) |
The positively rotating formylchroman compound is condensed with the C15-phosphonium bromide to give (2S,4'R,8'R)-1',2'-dehydro-a-tocopherol acetate. After catalytic hydrogenation of the double bond and hydrolysis of the acetate grouping, (2R,4'R,8'R)-a-tocopherol is produced. [Table 0003] (Ref. 0008) |
Ataxia with vitamin E deficiency (AVED), or familial isolated vitamin E deficiency, is a rare autosomal recessive neurodegenerative disease characterized clinically by symptoms with often striking resemblance to those of Friedreich ataxia. (Ref. 0042) |
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| 2 |  |
2-epi-a-tocopherol |
2S-(4'R,8'R,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0002 | Fumiko Hirahara |
l-a-Toc |
C29H50O2 | 430.706 | |
(2S,4'R,8'R)-a-tocopherol can be conveniently prepared by an alternative procedure starting from (2R,4'R,8'R)-a-tocopherol as follows. [Table 0001] (Ref. 0008) |
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| 3 |  |
2-ambo-a-tocopherol |
2RS-(4'R,8'R,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0003 | Fumiko Hirahara |
2-ambo-a-toc |
C29H50O2 | 430.706 | |
(2RS,4'R,8'R)-a-tocopherol was first synthesized from trimethylhydroquinone and 1,3-dibromophythane. Subsequently, a method for condensing phytyl bromide, prepared from natural phytol, with trimethylhydroquinone in petroleum ether with zinc chloride as the catalyst, was reported. This synthesis was also achieved by directly condensing phytol with trimethylhydroquinone. (Ref. 0001) Synthesis of (2RS,4'R,8'R)-a-tocopherol [Table 0002] (Ref. 0008) |
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| 4 |  |
all-rac-a-tocopherol |
2RS-(4'RS,8'RS,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0004 | Fumiko Hirahara |
all-rac-a-toc |
C29H50O2 | 430.706 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. RRR-a-tocopherol has been reported as 135-194% more than all-rac-a-tocopherol when evaluated by the rat resorption-gestation test , about 200% in terms of tissue retention of deuterated tocopherols in rat and human. The relationship between a-tocopherol and its derivatives was announced by USP. [Tables 0008/0009) RRR-a-tocopherol has been assigned an activity of 1 mg a-TE per milligram. [Table 0010] (Ref. 0034/0035/0036) |
practically insol in water , freely sol in acetone, in ethanol, in ether, in methylene chloride and in fatty oils (Ref. 0002) |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
(2RS,4'RS,8'RS)-a-tocopherol was synthesized from trimethylhydroquinone and racemic phytol. [Table 0002] (Ref. 0008) |
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| 5 |  |
b-tocopherol |
2R-(4R',8R',12'-trimethyltridecyl)-2,5,8-trimethylchroman-6-ol |
VVE0005 | Fumiko Hirahara |
b-Toc |
C28H48O2 | 416.680 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. RRR-b-tocopherol has been reported as 25-40% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test. [Table 0008] RRR-b-tocopherol has been assigned an activity of 0.5 mg a-TE per milligram. [Table 0010] (Ref. 0034/0035/0036) |
200-210 (Ref. 0009) |
Freely soluble in oils, fats, acetone, alcohol, chlororoform, ether, other fat solvents.(Ref. 0009) |
296nm, E1%1cm=89.4(ethanol)(Ref. 0001) |
3320,2940,1595,1458,1373,1229,1158,860cm-1 |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
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| 6 |  |
g-tocopherol |
2R-(4'R,8'R,12'-trimethyltridecyl)-2,7,8-trimethylchroman-6-ol |
VVE0006 | Fumiko Hirahara |
g-Toc |
C28H48O2 | 416.680 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. RRR-g-tocopherol has been reported as 1-11% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test. [Table 0008] RRR-g-tocopherol has been assigned an activity of 0.1 mg a-TE per milligram. [Table 0010] (Ref. 0034/0035/0036) |
200-210 (Ref. 0009) |
Freely soluble in oils, fats, acetone, alcohol, chlororoform, ether, other fat solvents.(Ref. 0009) |
298nm, E1%1cm=91.4(ethanol) |
3310,2930,1613,1460,1375,1220,1143,870cm-1 |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
g-Tocopherol is the major tocopherol in nature and therefore predominates in diet. 1.Soybean oil 2.Corn oil 3.Mixed vegetable oil 4.Mixed salad oil 5.Sesame oil 6.Cottonseed oil 7.Pistachio nuts 8.Walnuts 9. Sesame seeds 10.Skipjack and frigate mackerel canned with oil 11.Pine nuts 12.Kinako 13.High linoleic acid type margarine 14.Brasil nuts 15.Popcorn 16.Tunas canned with oil 17.Peanuts 18.Sencha 19.Milk chocolate 20.Buckwheat flour 21.Hazelnuts 22.Dry cowpeas 23.Rice-kojimiso 24.Raw green soybeans 25.Peanut oil (Ref. 0003/0005/0006/0033/0034) |
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| 7 |  |
d-tocopherol |
2R-(4'R,8'R,12'-trimethyltridecyl)-2,8-dimethylchroman-6-ol |
VVE0007 | Fumiko Hirahara |
d-Toc |
C27H46O2 | 402.653 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. RRR-d-tocopherol has been reported as 1% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test. [Table 0008] RRR-d-tocopherol has been assigned an activity of 0.03 mg a-TE per milligram. [Table 0010] (Ref. 0034/0035/0036) |
298nm, E1%1cm=87.3(ethanol) |
3360,2915,1605,1460,1375,1210,1145,855cm-1 |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
1.Soybean oil 2.Mixed vegetable oil 3.Kori-dofu 4.Dry cowpea 5.Hard type margarine 6.Soft type margarine 7.Dry azuki-beans 8.Dry soybeans 9.Mixed salad oil 10.kinako 11.Whole egg type mayonnaise 12.High linoleic acid type margarine 13.Egg yolk type mayonnaise 14.Skipjack and frigate mackerel canned with oil 15.Shortening 16.Soybean-koji miso (Ref. 0003/0005/0006/0033/0034) |
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| 8 | No image | RRS-a-tocopherol |
2R-(4'R,8'S,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0008 | Fumiko Hirahara |
RRS-a-toc |
C29H50O2 | 430.706 | H. Mayer and O.Isler's review is recommended to study precisely. (Ref. 0008) |
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| 9 | No image | RSR-a-tocopherol |
2R-(4'S,8'R,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0009 | Fumiko Hirahara |
RSR-a-toc |
C29H50O2 | 430.706 | H. Mayer and O.Isler's review is recommended to study precisely. (Ref. 0008) |
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| 10 | No image | RSS-a-tocopherol |
2R-(4'S,8'S,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0010 | Fumiko Hirahara |
RSS-a-toc |
C29H50O2 | 430.706 | H. Mayer and O.Isler's review is recommended to study precisely. (Ref. 0008) |
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| 11 | No image | SRS-a-tocopherol |
2S-(4'R,8'S,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0011 | Fumiko Hirahara |
SRS-a-toc |
C29H50O2 | 430.706 | H. Mayer and O.Isler's review is recommended to study precisely. (Ref. 0008) |
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| 12 | No image | SSR-a-tocopherol |
2S-(4'S,8'R,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0012 | Fumiko Hirahara |
SSR-a-toc |
C29H50O2 | 430.706 | H. Mayer and O.Isler's review is recommended to study precisely. (Ref. 0008) |
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| 13 | No image | SSS-a-tocopherol |
2S-(4'S,8'S,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0013 | Fumiko Hirahara |
SSS-a-tocopherol |
C29H50O2 | 430.706 | H. Mayer and O.Isler's review is recommended to study precisely. (Ref. 0008) |
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| 14 |  |
5,7-dimethyltocol |
2-(4'R,8'R12'-trimethyltridecyl)-2,5,7-trimethylchroman-6-ol |
VVE0014 | Fumiko Hirahara |
|
200-220 C/0.05mm |
292nm, E1%1cm=83.0(ethanol) |
3450,2920,1460,1375,1245,1155,1050 and 855 cm-1 (liquid film) |
1H-NMR:6.49,2.59,2.14 and 1.78 ppm |
5,7-Dimethyltocol was prepared by the reaction of phytol or isophytol and 2,6-dimethylhydroquinone in the presence of formic acid. (Ref. 0001) |
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| 15 | No image | 7-methyltocol |
2-(4'R,8'R,12'-trimethyltridecyl)-2,7-dimethylchroman-6-ol |
VVE0015 | Fumiko Hirahara |
150 C(bath)/10-3mm |
298nm, E1%1cm=104.1(ethanol) |
3370,2890,1500,1455,1370,1240,1175,1100 and 870 cm-1 (liquid film) |
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| 16 | No image | 5-methyltocol |
2-(4'R,8'R,12'-trimethyltridecyl)-2,5-dimethylchroman-6-ol |
VVE0016 | Fumiko Hirahara |
140 C/10-3mm |
296nm, E1%1cm=82.4(ethanol) |
3440,2915,1460,1380,1285,1155,1065 and 862 cm-1 (liquid film) |
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| 17 |  |
tocol |
2-(4'R,8'R,12'-trimethyltridecyl)-2-methylchroman-6-ol |
VVE0017 | Fumiko Hirahara |
C26H44O2 | 388.626 | |
b.p..1300.001=165-175 (Ref. 0010) |
298.5nm, E1%1cm=97(ethanol) |
3375,2915,1490,1450,1375,1285,1217,1152,1106 and 861 cm-1 (liquid film) |
Tocol was obtained by condensing phytol and hydroquinone using formic acids as the catalyst. (Ref. 0001) |
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| 18 |  |
all-trans-a-tocotrienol |
2-(4',8',12'-trimethyltrideca-3',7',11'-trienyl)-2,5,7,8-tetramethylchroman-6-ol |
VVE0018 | Fumiko Hirahara |
a-T3 |
C29H44O2 | 424.658 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. all-trans-a-tocotrienol has been reported as 29% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test. [Table 0008] all-trans-a-tocotrienol has been assigned an activity of 0.3 mg a-TE per milligram. [Table 0010] (Ref. 0034/0035/0036) |
m.p.30-31 C |
290 nm, E1%1cm=77.2(ethanol) |
3420,1435,1368,1242,1155,1075,917 and 851 cm-1 |
1H-NMR:d 5.12,4.15,2.58,2.10-1.58 and 1.23 ppm, NMR Spectrum of all-trans-a-Tocotrienol(60 MHz:CDCl3) [Spectrum 0001] (Ref. 0032) |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
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| 19 |  |
b-tocotrienol |
2-(4',8',12'-trimethyltrideca-3',7',11'-trienyl)-2,5,8-trimethylchroman-6-ol |
VVE0019 | Fumiko Hirahara |
b-T3 |
C28H42O2 | 410.632 | |
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. all-trans-b-tocotrienol has been reported as 5% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test. [Table 0008] all-trans-b-tocotrienol has been assigned an activity of 0.05 mg a-TE per milligram. [Table 0010] (Ref. 0034/0035/0036) |
230 C(bath)/0.05mm |
295 nm, E1%1cm=85.0(ethanol) |
3370,1592,1439,1404,1370,1220,1153,1091,1053,997,847 and 691 cm-1 |
1H-NMR: 6.45,5.12,4.38,2.62,2.08-1.62,1.25 ppm NMR Spectrum of b-Tocotrienol(60 MHz:CDCl3) [Spectrum 0001] (Ref. 0032) |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
1.Barley 2.Wheat Germ (Ref. 0034) |
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| 20 |  |
g-tocotrienol |
2-(4',8',12'-trimethyltrideca-3',7',11'-trienyl)-2,7,8-trimethylchroman-6-ol |
VVE0020 | Fumiko Hirahara |
g-T3 |
C28H42O2 | 410.632 | |
296 nm, E1%1cm=91(ethanol) |
3440,1667 and 1618 cm-1 |
1H-NMR: 6.35,5.13,4.28,2.68,2.12-2.02,1.68-1.62 and 1.25 ppm |
M=410 |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
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| 21 |  |
d-tocotrienol |
2-(4',8',12'-trimethyltrideca-3',7',11'-trienyl)-2,8-dimethylchroman-6-ol |
VVE0021 | Fumiko Hirahara |
d-T3 |
C27H40O2 | 396.605 | |
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E. [Chromatogram 0005] (Ref. 0038) |
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| 22 | No image | 2-(4',8',12'-trimethyltrideca-3',7',11'-trienyl)-2-methylchroman-6-ol |
VVE0022 | Fumiko Hirahara |
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| 23 |  |
1-aza-a-tocopherol |
6-hydroxy-2,5,7,8-tetramethyl-2-(4',8',12'-trimethyltridecyl)-1,2,3,4-tetrahydroquinoline |
VVE0023 | Fumiko Hirahara |
|
210 C/0.02mm |
240 and 301nm;E1%1cm=164 and 70(ethanol) |
3330,1600,1580,1439,1368,1245,1200,1121,1073,1002,962,760cm-1 |
1H-NMR:4.07,3.20,2.63,2.13,2.03,1.70,1.35,1.22,0.97,0.77 ppm |
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| 24 | No image | VVE0024 | Fumiko Hirahara |
1H-NMR:d(CDCl3) 0.79-1.73,1.50,2.09,2.10,2.13,280,2.9513C-NMR:d(CDCl3) 151.7,147.0,123.5,123.2,119.3,115.4 |
m/e:416,191,165 |
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| 25 | No image | 3,4-dehydro-a-tocopherol |
2-(4',8',12'-trimethyltridecyl)-2,5,7,8-tetramethyl-3,4-dehydrochroman-6-ol |
VVE0025 | Fumiko Hirahara |
130C (bath)/0.015mm |
235,273,283 and 339nm(e=19100,8300,7400 and 3200) |
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| 26 |  |
Trolox |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
VVE0026 | Fumiko Hirahara |
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m.p.190-192 |
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| 27 | No image | a-tocopherthiol |
2-(4',8',12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-thiol |
VVE0027 | Fumiko Hirahara |
190-200 C/0.005mm |
241 and 289nm; E1%1cm=184 and 33 (ethanol) |
1H-NMR(CDCl3): 2.85,2.62(t,J=7Hz),2.36,2.32,2.13,1.77(t),1.50,1.23,0.90,0.88 and 0.83 ppm |
m/e=446 |
Condensation of 2,3,5-methylphenol with isophytol and zinc chloride in formic acid yields 6-deoxy-a-tocopherol. Subsequent reduction with zinc in methanolic hydrogen chloride leads to a-tocopherthiol. (Ref. 0001) |
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| 28 | No image | 2,2,5,7,8-pentamethylchroman-6-ol |
VVE0028 | Fumiko Hirahara |
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| 29 | No image | 2,2,5,8-tetramethylchroman-6-ol |
VVE0029 | Fumiko Hirahara |
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| 30 | No image | 2,2,7,8-tetramethylchroman-6-ol |
VVE0030 | Fumiko Hirahara |
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| 31 | No image | 2,2,8-trimethylchroman-6-ol |
VVE0031 | Fumiko Hirahara |
C29H50O2 | 430.706 | ||||||||||||||||||||||
| 32 |  |
a-tocopherolquinone |
6-(3-hydroxy-3,7,11,15-tetramethylhexadecanyl)-2,3,5-trimethyl-1,4-benzoquinone |
VVE0032 | Fumiko Hirahara |
C29H50O2 | 430.706 | |
Synthesis of a-Tocopherol Quinone [FT0004] (Ref. 0013) |
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| 33 |  |
d-a-tocomonenol |
2,5,7,8-tetramethyl-2-(4',8',12'-trimethyltrideca-11'-enyl)-6-chroman-6-ol |
VVE0033 | Fumiko Hirahara |
d-a-tocomonenol |
|
JMN-GX 400 NMR by dissolving d-a-tocomonoenol in CDCl3 [[SP003] (Ref. 0012) |
JMX-DX 300 mass spectrometer ; m/e 428: molecular ion peak [[SP004] (Ref. 0012) |
HPLC HPLC condition1: column, Zorbax SIL(5mm, 250mmX4.6mm, Du Pont); mobile phase, n-hexane:dioxane:2-propanol=985:10:5); temperature, 30 ; flow rate, 1.5 mL/min; Ex 290nm; Em 330nm/HPLC condition2: column, Inertsil(5mm, 250mmX4.6mm, Du Pont); mobile phase, methanol:water=95:5); temperature, 30 ; flow rate, 1.0 mL/min; Ex 290nm; Em 330nm[Chromatogram 0001] (Ref. 0012) |
palm oil/rice bran oil(Ref. 0012) |
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| 34 | No image | 5R-hydroxy-2R-(4'R,8'R,12'-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6(5H)-one |
VVE0034 | Fumiko Hirahara |
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| 35 |  |
d-a-tocopherol acetate/d-a-tocopheryl acetate/RRR-a-tocopheryl acetate/Vitamin E acetate |
[2R-[2R(4R,8R)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol acetate |
VVE0035 | Koichi Abe |
d-a-toc ace |
C31H52O3 | 472.743 | |
28 (Ref. 0014) |
Practically insoluble in water /Soluble in alcohol/ Freely soluble in acetone, ethanol, ether and fatty oils(Ref. 0002) |
RRR-a-tocopherol acetate is broken down in gastrointestinal tract, resulting in absorption of a-tocopherol.(Ref. 0037)The apparent absorption of RRR-a-tocopherol in human is found to be similar whether administered as the free phenol, the acetyl ester, or the succinyl ester.(Ref. 0044) All-rac-a-tocopherol compared with RRR-a-tocopherol is preferentially metabolized to a-CEHC and excreted.(Ref. 0043) |
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| 36 | No image | l-a-tocopherol acetate/l-a-tocopheryl acetate/Vitamin E acetate |
[2S-[2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol acetate |
VVE0036 | Koichi Abe |
l-a-toc ace |
C31H52O3 | 472.743 | 23 (Ref. 0014) |
Practically insoli n water /Freely sol in acetone, chloroform, ether/Less readily sol in alc. |
l-a-tocopherol acetate is broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. |
|||||||||||||||||
| 37 |  |
dl-a-tocopherol acetate/dl-a-tocopheryl acetate/Vitamin E acetate |
[2RS-[2RS(4RS,8RS)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol acetate |
VVE0037 | Koichi Abe |
dl-a-toc ace |
C31H52O3 | 472.743 | |
all-rac-a-tocopherol acetate activity was announced as 1.0 IU/mg by USP. [Table 0009] all-rac-a-tocopherol acetate has been assigned an activity of 0.74 mg a-TE per milligram. [Table 0010] (Ref. 0035/0036) |
-27.5 (Ref. 0018) |
optically inactive(Ref. 0017) |
Practically insol in water /Freely sol in acetone, chloroform, ether/Less readily sol in alc (Ref. 0001) |
UVmax(cyclohexane)=285.5 nm(Ref. 0015)/UVmax(Ethanol)=285.5 nm(Ref. 0016)E1%&1cm(284nm)=44.5(Ref. 0016)/U=2.24X10312.411 mg of dl-a- tocopheryl acetate per 100ml of cyclohexane; [Spectrum 0005] (Ref. 0018) |
Perkin-Elmer 621 Spectrometer on a capillary layer of the liquid between KBr discs ;2943 and 2861(cm-1): CH3 stretching vibrations, 2920 and 2850(cm-1): CH2 stretching vibrations, 1752(cm-1): C=O stretching vibrations, 1456(cm-1): CH2 and CH3 deformations,1363(cm-1): CH3 symmetric defamations,1263(cm-1): C-O-C stretching vibrations [Spectrum 0006] (Ref. 0018) |
Jeolco 60 MHz NMR by dissolving 92.4 mg of dl-a-tocopheryl acetate in 0.5 ml of CDCl3 containing tetramethylsilane as an internal reference; [Spectrum 0007] (Ref. 0018) |
CEC 21-110 mass spectrometer with an ionizing energy of 70 eV; m/e 472: molecular ion peak, m/e 430: the loss of ketene from the molecular ion [Spectrum 0008] (Ref. 0018) |
TLC Plate;Silica Gel G plate, Developing Solvent; cyclohexane : ethyl ether(4: 1) Rf=0.7 GLC Column;5-10% SE-30 Silanized Diatomaceous Earth in Pyrex, Column Temperature; 280 , Carrier: N2 gas ca.40ml/min , retention Time; 26min (Ref. 0018) |
dl-a-tocopherol is dissolved in acetic anhydride and heated to 140 . The solution is then taken up in petroleum ether, the solvents are removed in vacuo at 80, and the residue is distilled under high vacuum at 200-210.(Ref. 0008) |
All-rac-a-tocopherol acetate is almost completely hydrolyzed prior to absorption, probably by a duodenal mucosal esterase and free a-tocopherol is then further metabolized to a-tocopherol quinine, a-tocopherol diver, a-tocopheronic acid and CEHC. When larger doses are administered, high blood levels are attained with tocopherol than with tocopheryl acetate administration. [Table 0004] (Ref. 0018/0019/0027/0037) The apparent absorption of RRR-a-tocopherol in human is found to be similar whether administered as the free phenol, the acetyl ester, or the succinyl ester.(Ref. 0044) All-rac-a-tocopherol compared with RRR-a-tocopherol is preferentially metabolized to a-CEHC and excreted.(Ref. 0043) |
||||||||
| 38 |  |
d-a-tocopherol succinate/d-a-tocopheryl succinate/RRR-a-tocopheryl hydrogen succinate/d-a-tocopheryl acid succinate/Vitamin E succinate/Vitamin E acid succinate |
[2R-[2R(4R,8R)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol succinate |
VVE0038 | Koichi Abe |
d-a-toc suc |
C33H54O5 | 530.779 | |
RRR-a-tocopherol succinate activity was announced as 1.21 IU/mg by USP. [Table 0009] (Ref. 0035/0036) |
76-77 (Ref. 0020) |
a in ethanol/d in benzene(Ref. 0020) |
Practically insol in water / sol in acetone, ethanol, ether/very soluble in methylene chloride(Ref. 0021) |
UVmax(ethanol)= 286nm/E1%1cm(284nm)=38.5(Ref. 0021) |
An a-tocopherol concentrate was heated with succinic anhydride in pyridine. The mixture was diluted with ethyl ether and was allowed to stand at 3 . Succinic anhydrides were well washed with ethyl ether. The filtrate, further diluted with ether, was washed with hydrochloric acid, wasted and dried. After distillation of ether a dark oily residue was obtained. This was dissolved in petroleum ether and adsorbed on a mixture of Special Filtrol and Hyflo Super Cel in an adsorbent column . The solution was forced through the column under nitrogen pressure. The column was washed with petroleum ether , then the strongly adsorbed a-tocopherol succinate was eluted with ethyl ether and recrystallized from a 10% solution in petroleum ether.(Ref. 0020) |
d-a-tocopherol succinate is broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. The apparent absorption of RRR-a-tocopherol in human is found to be similar whether administered as the free phenol, the acetyl ester, or the succinyl ester.(Ref. 0044) |
||||||||||||
| 39 | No image | l-a-tocopherol succinate/l-a-tocopheryl succinate/l-a-tocopheryl acid succinate/Vitamin E succinate/Vitamin E acid succinate |
[2S-[2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol succinate |
VVE0039 | Koichi Abe |
l-a-toc suc |
C33H54O5 | 530.779 | l-a-tocopherol succinate is broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. |
|||||||||||||||||||
| 40 |  |
dl-a-tocopherol succinate/dl-a-tocopheryl succinate/dl-a-tocopheryl acid succinate/Vitamin E succinate/Vitamin E acid succinate |
[2RS-[2RS(4RS,8RS)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol succinate |
VVE0040 | Koichi Abe |
dl-a-toc suc |
C33H54O5 | 530.779 | |
76-77 (Ref. 0022) |
Practically insol in water (Ref. 0022)/ sol in acetone, ethanol, ether/very soluble in methylene chloride |
UVmax(ethanol)= 286nm(Ref. 0022) |
GLC Column;5-10% SE-30 Silanized Diatomaceous Earth in Pyrex, Column Temperature; 280 , Carrier: N2 gas ca.40ml/min , retention Time; 23min (Ref. 0018) |
RRR-a-tocopherol succinate is broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. The apparent absorption of RRR-a-tocopherol in human is found to be similar whether administered as the free phenol, the acetyl ester, or the succinyl ester.(Ref. 0044) |
||||||||||||||
| 41 | No image | d-a-tocopherol nicotinate/d-a-tocopheryl nicotinate/Vitamin E nicotinate |
[2R-[2R(4R,8R)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol nicotinate |
VVE0041 | Koichi Abe |
d-a-toc nic |
C35H53NO3 | 535.800 | UVmax(ethanol)= 263-265 nm |
d-a-tocopherol nicotinate may be broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. |
||||||||||||||||||
| 42 | No image | l-a-tocopherol nicotinate/l-a-tocopheryl nicotinate/Vitamin E nicotinate |
[2S-[2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol nicotinate |
VVE0042 | Koichi Abe |
l-a-toc nic |
C35H53NO3 | 535.800 | UVmax(ethanol)= 263-265 nm |
l-a-tocopherol nicotinate may be partially broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. |
||||||||||||||||||
| 43 |  |
dl-a-tocopherol nicotinate/l-a-tocopheryl nicotinate/Vitamin E nicotinate |
[2RS-[2RS(4RS,8RS)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol nicotinate |
VVE0043 | Koichi Abe |
dl-a-toc nic |
C35H53NO3 | 535.800 | |
about 38 |
very sol in acetone, ethanol, ether/freely soluble in ethanol/practically insol i water.(Ref. 0024) |
UVmax(ethanol)= 263-265 nm |
dl-a-tocopherol nicotinate is partially hydrolysed in gastrointestinal tract, resulting in absorption of a-tocopherol. |
|||||||||||||||
| 44 |  |
dl-a-tocopherol succinate Ca/dl-a-tocopheryl succinate Ca/dl-a-tocopheryl acid succinate Ca/Vitamin E succinate Ca/Vitamin E acid succinate Ca |
[2RS-[2RS(4RS,8RS)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol succinate monocalcium salt |
VVE0044 | Koichi Abe |
dl-a-toc suc Ca |
C33H54O5 | 530.779 | |
Optically inactive(Ref. 0025) |
Freely soluble in chloroform, carbon tetrachloride/Practically insoluble in water, ethanol , acetone (Ref. 0025) |
UVmax(chloroform)= 286 nm (Ref. 0025) /E1%1cm(284nm)=36.0-40.0(chloroform) |
d-a-tocopherol succinate calcium is broken down in gastrointestinal tract, resulting in absorption of a-tocopherol. |
|||||||||||||||
| 45 |  |
DL-a-tocopheryl retinoate/Tocoretinate |
2RS-2,5,7,8-tetramethyl-2-[(4RS,8RS)-4,8,12-trimethyltridecyl]-6-chromanyl retinoate |
VVE0045 | Koichi Abe |
C49H76O3 | 713.126 | |
UVmax(ethanol)= 365nm/E1%1cm(365nm)=642(Ref. 0040) |
|||||||||||||||||||
| 46 |  |
2-(a-D-glucopyranosyl)-2,5,7,8-teramethylchroman-6-ol |
VVE0046 | Koichi Abe |
TMG |
C20H30O8 | 398.447 | |
freely soluble in water(Ref. 0028) |
UVmax(ethanol)= 291nm(Ref. 0028) |
3400,2920,1640,1460,1420,1380,1260,1150,1110,1030 and 920 cm-1(Ref. 0028) |
m/Z; 398(M+), 237,219, 205,191,165 (fragment ion) (Ref. 0028) |
||||||||||||||||
| 47 |  |
Phosphatidylchromanol |
1,2-dimyristoyl-sn-glycero-3-phospho-2'-hydrxyethyl-2',5',7',8'-tetramethyl-6'-hydroxychroman |
VVE0047 | Koichi Abe |
PCh |
|
Antioxidant Activity (Ref. 0001) |
M+H+=825 (Ref. 0030) |
|||||||||||||||||||
| 48 |  |
2,7,8-trimethyl-2-(b-carboxyethyl)-6-hydroxychroman |
VVE0048 | Koichi Abe |
LLU-a |
C12H18O4 | 226.269 | |
Natriuretic Factor(Ref. 0001) |
147-148 C |
||||||||||||||||||
| 49 |  |
a-carboxyethyl-6-Hydroxychroman |
2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman |
VVE0049 | Koichi Abe |
a-CEHC/5-Me-LLU-a |
|
HPLC chromatograms: Column; LiChrospher RP 8, Mobile phase; a Gradient of acetonitrile-McIlvain buffer, detection;210nm with the diode array [Chromatogram 0001] Gas chromatograms: column; a fused silica DB-MS capillary column, temperature;180-280 (10/min, 20min isothermic) [Chromatogram 0003] (Ref. 0027) |
||||||||||||||||||||
| 50 |  |
Raxofelast |
5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuran acetic acid |
VVE0050 | Koichi Abe |
IRFI-016 |
|
|||||||||||||||||||||
| 51 |  |
dl-a-tocopherol linoleate |
[2RS-[2RS(4RS,8RS)] ]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol linoleate |
VVE0051 | Koichi Abe |
C47H80O3 | 693.136 | |
d2020=0.930-0.942(Ref. 0045) |
n20D=1.495-1.449(Ref. 0045) |
E1%1cm(286nm)=31-40(0.01g,hexane,100ml)(Ref. 0045) |
|||||||||||||||||
| 52 |  |
Troglitazone |
5-[ [4-[(3,4-Dihydro-6-hydroxy-2,5-7,8-tetramethyl-2H-1-benzopyran-2-y)methoxy]phenyl]methyl]-2,4-thiazolidine |
VVE0052 | Koichi Abe |
C24H27NO5S | 441.541 | |
Anti diabetic. |
mp=184-186 (Ref. 0046) |
||||||||||||||||||
| 53 |  |
a-tocopherol quinone/a-tocopheryl quinone |
2-(3-hydroxy-4,8,12-trimethyltridecyl)-3,5,6-trimethylbenzoquinone |
VVE0053 | Koichi Abe |
a-TQ |
C29H50O2 | 430.706 | |
lmax=269nm, loge=4.21 (Ref. 0047) |
C=Ostretch of quinone=1641 cm-1(Ref. 0047) |
a-tocopherol is oxidized by ferric chloride, silver nitrate or chloro-auric acid to a-tocopherylquinone.(Ref. 0055) |
||||||||||||||||
| 54 |  |
2,8-dimethyl-2(2'-carboxyethyl)-6-hydroxychroman |
VVE0054 | Koichi Abe |
d-CEHC |
C14H18O4 | 250.290 | |
IR spectrum of d-CEHC methyl ester (Ref. 0048) |
NMR spectrum of d-CEHC methyl ester (Ref. 0048) |
To a mixture of 2-methyl-1,4-benzohydroquinone-4-benzoate, dioxane and BF3-ether, a solution of g-vinyl-g-valerolactone in dioxane was added drop wise. The reaction mixture was extracted with ether. The extract was hydrolyzed, diluted with water and extracted with ethyl acetate. The extracted residue was chromatographed and then recrystallized. |
|||||||||||||||||
| 55 |  |
g-tocopherol quinone/g-tocopheryl quinone |
2-(3-hydroxy-4,8,12-trimethyltridecyl)-5,6-dimethylbenzoquinone |
VVE0055 | Koichi Abe |
g-TQ |
C28H48O2 | 416.680 | |
g-tocopherol is oxidized by ferric chloride to a-tocopherylquinone.(Ref. 0055) |
||||||||||||||||||
| 56 |  |
d-tocopherol quinone/d-tocopheryl quinone |
2-(3-hydroxy-4,8,12-trimethyltridecyl)-6-methylbenzoquinone |
VVE0056 | Koichi Abe |
d-TQ |
C27H4602 | 4962.829 | |
|||||||||||||||||||
| 57 |  |
2,2,5,7,8-Pentamethyl-6-hydroxychroman |
VVE0057 | Koichi Abe |
PMC |
C14H20O2 | 220.307 | |
PMC inhibits induction of nitric oxide synthase by bacterial Lipopolysaccharide. (Ref. 0056) |
|||||||||||||||||||
| 58 |  |
L-Ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramathyl-2-(4,8,12-trimethyltridecyl)-2-1-benzopyran-6-yl hydrogen phosphate] potassium salt |
VVE0058 | Koichi Abe |
EPC-K1 |
C35H56O16PK | 802.882 | |
sol in water ,Less readily sol in methanol, practically insol in acetone, in ethyl acetate, in ether, in chloroform |
|||||||||||||||||||
| 59 |  |
2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6,-dii-tert-butylbenzofuran |
VVE0059 | Koichi Abe |
BO-653 |
C26H44O2 | 388.626 | |
radical scavenging action. |
|||||||||||||||||||
| 60 |  |
[2R-[2R(4R,8R)] ]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol palmitate |
VVE0060 | Koichi Abe |
d-alpha-Toc palmitate |
C45H80O3 | 669.115 | |
42-43 (Ref. 0057) |
UVmax=280nm, E1%1cm=30.9(Ref. 0057) |
||||||||||||||||||
| 61 |  |
[2RS-[2RS(4SR,8SR)] ]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol palmitate |
VVE0061 | Koichi Abe |
dl-alpha-palmitate |
C45H80O3 | 669.115 | |
36-38 (Ref. 0057) |
UVmax=286nm, E1%1cm=36.8(Ref. 0057) |
||||||||||||||||||
| 62 |  |
the (-) enantiomer of the racemate U-78517F |
[2-[4-[2,6-di-(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol, dihydrochloride |
VVE0062 | Koichi Abe |
U-83836-E |
C30H46O2N6Cl2 | 593.631 | |
|||||||||||||||||||
| 63 |  |
RRR-a-tocopheryl polyethylene glycol succinate/Tocophersolan |
Poly(oxy-1,2-ethanediyl), a-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridcyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl-w-hydroxy- |
VVE0063 | Koichi Abe |
TPGS |
|
|||||||||||||||||||||
| 64 |  |
2-(3-chloropropyl)-2,5,7,8-tetramethyl-6-chromanol |
VVE0064 | Koichi Abe |
C16H23ClO2 | 282.805 | |
1H-NMR(CDCl3) d:4.20(1H,s), 3.53(2H,t,J=6.4Hz), 2.61(2H,t,J=6.7Hz), 2.46-2.21(2H,m), 2.13, 2.10(9H,s), 2.05-1.63(4H,m), 1.25(3H,s)(Ref. 0051) |
m/z: 282(M+)(Ref. 0051) |
|||||||||||||||||||
| 65 |  |
2R,4R,8R-2,4,6,7-tetramethyl-2-(4,8,12-trimethyl-2-(4,8,12-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran |
VVE0065 | Koichi Abe |
C28H4802 | 5176.427 | |
|||||||||||||||||||||
| 66 |  |
dl-a-Tocpheryl p-nitrobenzoate |
[2RS-[2RS(4SR,8SR)] ]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecey)-2H-1-benzopyran-6-ol p-nitrobenzoate |
VVE0066 | Koichi Abe |
C36H53O5N |
|
46-47 (Ref. 0057) |
||||||||||||||||||||
| 67 |  |
spirodienone ether dimer |
VVE0067 | Koichi Abe |
|
5.97, 6.03 and 6.27m(carbonyl and conjugated double bonds), 7.96, 9.13, 10.36m(ether) (Ref. 0053) |
||||||||||||||||||||||
| 68 |  |
a-tocopheronic acid |
2-(3-hydroxy-3-methyl-5-carboxypentyl)-3,5,6-trimethylbennzoquinone |
VVE0068 | Koichi Abe |
C16H2205 | 2414.679 | |
IR spectra of a-tocopheronic acid, its g-lactone and hydroquinone diacetate(Ref. 0049) |
|||||||||||||||||||
| 69 |  |
N-Methyl-2,2,7,8-tetramethyl-6-amino-chromane |
VVE0069 | Koichi Abe |
N-Me-Me4-C |
C14H20ON | 218.315 | |
IR spectrum of N-Me-Me4-C[SP] (Ref. 0052) |
NMR spectrum of N-Me-Me4-C[SP] (Ref. 0052) |
||||||||||||||||||
| 70 |  |
5-Nitro-g-tocopherol |
2R-(4'R,8'R,12'-trimethyltridecyl)-5-nitro-2,7,8-trimethyl-chroman-6-ol |
VVE0070 | Koichi Abe |
5-NO2-gT |
C26H4704N | 5067.635 | |
|||||||||||||||||||
| 71 |  |
Tocored |
2RS-(4'RS,8'RS,12'-trimethyltridecyl)-2,7,8-trimethylchroman-5,6-quinone |
VVE0071 | Koichi Abe |
C28H46O3 | 430.663 | |
UVmax=257,261nm(Ref. 0055) |
When g-tocopherol is oxidized with ferric chloride in the absence of aa'-dipyridyl, tocored is obtained.(Ref. 0055) |
||||||||||||||||||
| 72 |  |
b-tocopherol quinone |
2-(3-hydroxy-4,8,12-trimethyltridecyl)-3,6-dimethylbenzoquinone |
VVE0072 | Koichi Abe |
b-TQ |
C28H48O2 | 416.680 | |
C=O stretch of quinone=1649 cm-1, C=C of quinone ring= 1617cm-1(Ref. 0047) |
b-tocopherol is oxidized by silver nitrate or ferric chloride to b-tocopherylquinone.(Ref. 0055) |
|||||||||||||||||
| 73 |  |
2-(2',5',7',8'-tetramethyl-6'-hydroxychromanyl)ethylphosphate |
VVE0073 | Koichi Abe |
Ch-P |
C15H22O6P | 329.305 | |
UVmax=290nm, u=2800(Ref. 0050) |
1H-NMR Chemical shifts of Ch-P(Ref. 0050) |
||||||||||||||||||
| 74 |  |
3,4-dihydro-6-hydroxy-N,N,N-2,5,7,8-heptamethyl-2H-1-benzppyran-2-ethanaminium 4-methylbenzenesulfonate |
VVE0074 | Koichi Abe |
MDL 73404 |
C18H30O2N | 292.436 | |
MDL 73404 is at least 40 tomes more potent inhibitors of Fe-driven heart microsomal lipid peroxidation than Trolox. (Ref. 0058) |
|||||||||||||||||||
| 75 |  |
3-Hydroxy-5-(1,2-dihydroxyethyl)-4-[6-hydroxy-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-chroman-5-ylmethoxy]-furan-2(5H)-one |
VVE0075 | Koichi Abe |
Tocpheryl Ascorbate |
C35H56O8 | 604.814 | |
||||||||||||||||||||
| 76 |  |
marine-derived tocopherol |
3,4-dihydro-2,5,7,8-tetramethyl- 2 - (4,8,12-trimethyl-12-tridecenyl) -2H-1-benzopyran-6-ol |
VVE0076 | Koichi Abe |
MDT |
C29H48O2 | 428.690 | |
HPLC retention time; MDT=10.1min, a-tcopherol=12.3min ( Column; Spelco LC-18, Mobile phase; 50 mM NaClO4 in methanol, Flow Rate; 1 ml/min) |
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| AUTHOR | : | Kasparek,S.(1980)Chemistry of Tocopherols and Tocotrienols, in Vitamin E, a comprehensive Treasure (Machlin, L.J. ,eds.), PP7-65, Marcel Dekker, INC., New York and Basel |
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| AUTHOR | : | Sheppard, A.J., Pennington,A.T.(1993) Analysis and Distribution of Vitamin E in Vegetable Oils and Foods, in Vitamin E in Health and Disease (Packer, L. , Fuchs, J. eds.),pp9-31,Marcel Dekker Inc , New York |
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| VOL | : | 62 PAGE : 237-240 (1985) |
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| TITLE | : | Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds PubMed ID:925769 |
| JOURNAL | : | J Nutr. |
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| AUTHOR | : | Evans H.M., Emerson,O.H. and Emerson,G.A. |
| TITLE | : | The Isolation from Wheat Germ Oil of an Alcohol, a-Tocopherol, having the Properties of Vitamin E. |
| JOURNAL | : | J. Biol. Chem. |
| VOL | : | 113 PAGE : 319-332 (1936) |
| AUTHOR | : | Isler, O., Mayer,H.(1971) [227]Synthesis of Vitamin E , in Methods in Enzymnology vol.18 (McCormick, D,B.,Wright,L. D eds.),pp241-348, Academic Press, New York and London |
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=+6.37
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