Category:LBS/Biosynthesis/CeramideSyn - Revision history

Editor at 04:30, 18 December 2017

2017-12-18T04:30:00Z

← Older revision		Revision as of 13:30, 18 December 2017
Line 25:		Line 25:
	\| [http://www.uniprot.org/uniprot/O15269 SPTLC1](LCB1)		\| [http://www.uniprot.org/uniprot/O15269 SPTLC1](LCB1)
	\| 9q22.31		\| 9q22.31
	\|rowspan="5"\| A heterodimer membrane protein (~~LC1~~-~~LC2~~ or ~~LC1~~-~~LC3~~) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.		\|rowspan="5"\| A heterodimer membrane protein (LCB1-LCB2 or LCB1-LCB3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity. SPTSSA/B has no homology with the Tsc3p subunit in yeast.<ref>Han G., Gupta S.D., Gable K., Niranjanakumari S., Moitra P., Eichler F., Brown R.H. Jr., Harmon J.M., Dunn T.M. (2009) "Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities" Proc. Natl. Acad. Sci. USA 106:8186-8191 PMID 19416851</ref>
	<ul>		<ul>
	<li>SPTLC1-SPTLC2-SPTSSA ... C16-CoA		<li>SPTLC1-SPTLC2-SPTSSA ... C16-CoA
Line 50:		Line 50:
	\|		\|
	\|-		\|-
	\|rowspan="6"\| Ceramide synthase		\|rowspan="6"\| Ceramide synthase <ref>Levy M, Futerman AH (2010) "Mammalian ceramide synthases" IUBMB Life 62(5):347-356 PMID 20222015</ref>
	\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1,LAG1)		\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1,LAG1)
	\| 19p13.11		\| 19p13.11
Line 78:		Line 78:
	\| [http://www.uniprot.org/uniprot/O15121 DEGS1](DES1)		\| [http://www.uniprot.org/uniprot/O15121 DEGS1](DES1)
	\| 1q42.11		\| 1q42.11
	\|rowspan="2"\| The enzyme hydroxylates DES to form phytoceramide.<ref>Michel C, van Echten-Deckert G. (1997) "Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum" FEBS Lett 416(2):153-155 </ref>		\|rowspan="2"\| The enzyme hydroxylates DES to form phytoceramide.<ref>Michel C, van Echten-Deckert G. (1997) "Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum" FEBS Lett 416(2):153-155 PMID 9369202</ref>
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)		\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)

Editor at 04:19, 18 December 2017

2017-12-18T04:19:03Z

← Older revision		Revision as of 13:19, 18 December 2017
Line 82:		Line 82:
	\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)		\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)
	\| 14q32.2		\| 14q32.2
			\|-
			\|colspan="4"\|<references/>
	\|}		\|}

Editor at 04:18, 18 December 2017

2017-12-18T04:18:24Z

← Older revision		Revision as of 13:18, 18 December 2017
Line 78:		Line 78:
	\| [http://www.uniprot.org/uniprot/O15121 DEGS1](DES1)		\| [http://www.uniprot.org/uniprot/O15121 DEGS1](DES1)
	\| 1q42.11		\| 1q42.11
	\|		\|rowspan="2"\| The enzyme hydroxylates DES to form phytoceramide.<ref>Michel C, van Echten-Deckert G. (1997) "Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum" FEBS Lett 416(2):153-155 </ref>
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)		\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)
	\| 14q32.2		\| 14q32.2
	~~\| The enzyme hydroxylates DES to form phytoceramide.~~
	\|}		\|}

Yoshimoto at 03:42, 18 December 2017

2017-12-18T03:42:35Z

← Older revision		Revision as of 12:42, 18 December 2017
Line 23:		Line 23:
	\|-		\|-
	\|rowspan="5"\| Serine palmitoyl transferase (SPT)		\|rowspan="5"\| Serine palmitoyl transferase (SPT)
	\| [http://www.uniprot.org/uniprot/O15269 SPTLC1] (LCB1)		\| [http://www.uniprot.org/uniprot/O15269 SPTLC1](LCB1)
	\| 9q22.31		\| 9q22.31
	\|rowspan="5"\| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.		\|rowspan="5"\| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.
Line 36:		Line 36:
	\| 14q24.3		\| 14q24.3
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3] (LCB2B)		\| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3](LCB2B)
	\| 20p12.1		\| 20p12.1
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA] (ssSPTa)		\| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA](ssSPTa)
	\| 14q13.1		\| 14q13.1
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB] (ssSPTb)		\| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB](ssSPTb)
	\| 3q26.1		\| 3q26.1
	\|-		\|-
	\|rowspan="1"\| 3-Ketodihydrosphingosine reductase		\|rowspan="1"\| 3-Ketodihydrosphingosine reductase
	\| [http://www.uniprot.org/uniprot/Q06136 KDSR]~~<br/>~~(FVT1)		\| [http://www.uniprot.org/uniprot/Q06136 KDSR](FVT1)
	\| 18q21.33		\| 18q21.33
	\|		\|
Line 59:		Line 59:
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8IU89 CERS3] (LASS3)		\| [http://www.uniprot.org/uniprot/Q8IU89 CERS3](LASS3)
	\| 15q26.3		\| 15q26.3
	\| Skin, testis for C22-C26 α-hydroxy chains		\| Skin, testis for C22-C26 α-hydroxy chains
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q9HA82 CERS4] (LASS4)		\| [http://www.uniprot.org/uniprot/Q9HA82 CERS4](LASS4)
	\| 19p13.2		\| 19p13.2
	\| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.		\| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8N5B7 CERS5] (LASS5)		\| [http://www.uniprot.org/uniprot/Q8N5B7 CERS5](LASS5)
	\| 12q13.12		\| 12q13.12
	\| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.		\| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6ZMG9 CERS6] (LASS6)		\| [http://www.uniprot.org/uniprot/Q6ZMG9 CERS6](LASS6)
	\| 2q24.3		\| 2q24.3
	\| Low in all tissues for C14-C16		\| Low in all tissues for C14-C16
	\|-		\|-
	\|rowspan="2"\|Dihydroceramide Δ4-desaturase		\|rowspan="2"\|Dihydroceramide Δ4-desaturase
	\| [http://www.uniprot.org/uniprot/O15121 DEGS1] (DES1)		\| [http://www.uniprot.org/uniprot/O15121 DEGS1](DES1)
	\| 1q42.11		\| 1q42.11
	\|		\|
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2] (DES2)		\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2](DES2)
	\| 14q32.2		\| 14q32.2
	\| The enzyme hydroxylates DES to form phytoceramide.		\| The enzyme hydroxylates DES to form phytoceramide.
	\|}		\|}

Yoshimoto at 03:40, 18 December 2017

2017-12-18T03:40:22Z

← Older revision		Revision as of 12:40, 18 December 2017
Line 23:		Line 23:
	\|-		\|-
	\|rowspan="5"\| Serine palmitoyl transferase (SPT)		\|rowspan="5"\| Serine palmitoyl transferase (SPT)
	\| [http://www.uniprot.org/uniprot/O15269 SPTLC1]~~<br/>~~(LCB1)		\| [http://www.uniprot.org/uniprot/O15269 SPTLC1] (LCB1)
	\| 9q22.31		\| 9q22.31
	\|rowspan="5"\| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.		\|rowspan="5"\| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.
Line 36:		Line 36:
	\| 14q24.3		\| 14q24.3
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3]~~<br/>~~(LCB2B)		\| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3] (LCB2B)
	\| 20p12.1		\| 20p12.1
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA]~~<br/>~~(ssSPTa)		\| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA] (ssSPTa)
	\| 14q13.1		\| 14q13.1
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB]~~<br/>~~(ssSPTb)		\| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB] (ssSPTb)
	\| 3q26.1		\| 3q26.1
	\|-		\|-
Line 59:		Line 59:
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8IU89 CERS3]~~<br/>~~(LASS3)		\| [http://www.uniprot.org/uniprot/Q8IU89 CERS3] (LASS3)
	\| 15q26.3		\| 15q26.3
	\| Skin, testis for C22-C26 α-hydroxy chains		\| Skin, testis for C22-C26 α-hydroxy chains
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q9HA82 CERS4]~~<br/>~~(LASS4)		\| [http://www.uniprot.org/uniprot/Q9HA82 CERS4] (LASS4)
	\| 19p13.2		\| 19p13.2
	\| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.		\| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8N5B7 CERS5]~~<br/>~~(LASS5)		\| [http://www.uniprot.org/uniprot/Q8N5B7 CERS5] (LASS5)
	\| 12q13.12		\| 12q13.12
	\| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.		\| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6ZMG9 CERS6]~~<br/>~~(LASS6)		\| [http://www.uniprot.org/uniprot/Q6ZMG9 CERS6] (LASS6)
	\| 2q24.3		\| 2q24.3
	\| Low in all tissues for C14-C16		\| Low in all tissues for C14-C16
	\|-		\|-
	\|rowspan="2"\|Dihydroceramide Δ4-desaturase		\|rowspan="2"\|Dihydroceramide Δ4-desaturase
	\| [http://www.uniprot.org/uniprot/O15121 DEGS1]~~<br/>~~(DES1)		\| [http://www.uniprot.org/uniprot/O15121 DEGS1] (DES1)
	\| 1q42.11		\| 1q42.11
	\|		\|
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2]~~<br/>~~(DES2)		\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2] (DES2)
	\| 14q32.2		\| 14q32.2
	\| The enzyme hydroxylates DES to form phytoceramide.		\| The enzyme hydroxylates DES to form phytoceramide.
	\|}		\|}

Yoshimoto at 03:38, 18 December 2017

2017-12-18T03:38:34Z

← Older revision		Revision as of 12:38, 18 December 2017
Line 33:		Line 33:
	</ul>		</ul>
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/O15270 SPTLC2]<br/>(LCB2, LCB2A)		\| [http://www.uniprot.org/uniprot/O15270 SPTLC2]<br/>(LCB2,LCB2A)
	\| 14q24.3		\| 14q24.3
	\|-		\|-
Line 51:		Line 51:
	\|-		\|-
	\|rowspan="6"\| Ceramide synthase		\|rowspan="6"\| Ceramide synthase
	\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1, LAG1)		\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1,LAG1)
	\| 19p13.11		\| 19p13.11
	\| Brain, skeletal muscle, testis for C18		\| Brain, skeletal muscle, testis for C18
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/>(LASS2, TMSG1)		\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/>(LASS2,TMSG1)
	\| 1q21.3		\| 1q21.3
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26

Yoshimoto at 03:38, 18 December 2017

2017-12-18T03:38:03Z

← Older revision		Revision as of 12:38, 18 December 2017
Line 33:		Line 33:
	</ul>		</ul>
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/O15270 SPTLC2]<br/>(LCB2,LCB2A)		\| [http://www.uniprot.org/uniprot/O15270 SPTLC2]<br/>(LCB2, LCB2A)
	\| 14q24.3		\| 14q24.3
	\|-		\|-
Line 46:		Line 46:
	\|-		\|-
	\|rowspan="1"\| 3-Ketodihydrosphingosine reductase		\|rowspan="1"\| 3-Ketodihydrosphingosine reductase
	\| [http://www.uniprot.org/uniprot/Q06136 KDSR] (FVT1)		\| [http://www.uniprot.org/uniprot/Q06136 KDSR]<br/>(FVT1)
	\| 18q21.33		\| 18q21.33
	\|		\|
	\|-		\|-
	\|rowspan="6"\| Ceramide synthase		\|rowspan="6"\| Ceramide synthase
	\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1,LAG1)		\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1, LAG1)
	\| 19p13.11		\| 19p13.11
	\| Brain, skeletal muscle, testis for C18		\| Brain, skeletal muscle, testis for C18
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/>(LASS2,TMSG1)		\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/>(LASS2, TMSG1)
	\| 1q21.3		\| 1q21.3
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26

Yoshimoto at 03:36, 18 December 2017

2017-12-18T03:36:14Z

← Older revision		Revision as of 12:36, 18 December 2017
Line 23:		Line 23:
	\|-		\|-
	\|rowspan="5"\| Serine palmitoyl transferase (SPT)		\|rowspan="5"\| Serine palmitoyl transferase (SPT)
	\| [http://www.uniprot.org/uniprot/O15269 SPTLC1] (LCB1)		\| [http://www.uniprot.org/uniprot/O15269 SPTLC1]<br/>(LCB1)
	\| 9q22.31		\| 9q22.31
	\|rowspan="5"\| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.		\|rowspan="5"\| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.
Line 36:		Line 36:
	\| 14q24.3		\| 14q24.3
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3] (LCB2B)		\| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3]<br/>(LCB2B)
	\| 20p12.1		\| 20p12.1
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA] (ssSPTa)		\| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA]<br/>(ssSPTa)
	\| 14q13.1		\| 14q13.1
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB] (ssSPTb)		\| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB]<br/>(ssSPTb)
	\| 3q26.1		\| 3q26.1
	\|-		\|-
Line 59:		Line 59:
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8IU89 CERS3] (LASS3)		\| [http://www.uniprot.org/uniprot/Q8IU89 CERS3]<br/>(LASS3)
	\| 15q26.3		\| 15q26.3
	\| Skin, testis for C22-C26 α-hydroxy chains		\| Skin, testis for C22-C26 α-hydroxy chains
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q9HA82 CERS4] (LASS4)		\| [http://www.uniprot.org/uniprot/Q9HA82 CERS4]<br/>(LASS4)
	\| 19p13.2		\| 19p13.2
	\| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.		\| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q8N5B7 CERS5] (LASS5)		\| [http://www.uniprot.org/uniprot/Q8N5B7 CERS5]<br/>(LASS5)
	\| 12q13.12		\| 12q13.12
	\| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.		\| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6ZMG9 CERS6] (LASS6)		\| [http://www.uniprot.org/uniprot/Q6ZMG9 CERS6]<br/>(LASS6)
	\| 2q24.3		\| 2q24.3
	\| Low in all tissues for C14-C16		\| Low in all tissues for C14-C16
	\|-		\|-
	\|rowspan="2"\|Dihydroceramide Δ4-desaturase		\|rowspan="2"\|Dihydroceramide Δ4-desaturase
	\| [http://www.uniprot.org/uniprot/O15121 DEGS1] (DES1)		\| [http://www.uniprot.org/uniprot/O15121 DEGS1]<br/>(DES1)
	\| 1q42.11		\| 1q42.11
	\|		\|
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2] (DES2)		\| [http://www.uniprot.org/uniprot/Q6QHC5 DEGS2]<br/>(DES2)
	\| 14q32.2		\| 14q32.2
	\| The enzyme hydroxylates DES to form phytoceramide.		\| The enzyme hydroxylates DES to form phytoceramide.
	\|}		\|}

Yoshimoto at 03:34, 18 December 2017

2017-12-18T03:34:57Z

← Older revision		Revision as of 12:34, 18 December 2017
Line 33:		Line 33:
	</ul>		</ul>
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/O15270 SPTLC2]<br/>(LCB2, LCB2A)		\| [http://www.uniprot.org/uniprot/O15270 SPTLC2]<br/>(LCB2,LCB2A)
	\| 14q24.3		\| 14q24.3
	\|-		\|-
Line 51:		Line 51:
	\|-		\|-
	\|rowspan="6"\| Ceramide synthase		\|rowspan="6"\| Ceramide synthase
	\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/> (LASS1, LAG1)		\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1,LAG1)
	\| 19p13.11		\| 19p13.11
	\| Brain, skeletal muscle, testis for C18		\| Brain, skeletal muscle, testis for C18
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/> (LASS2, TMSG1)		\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/>(LASS2,TMSG1)
	\| 1q21.3		\| 1q21.3
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26

Yoshimoto at 03:34, 18 December 2017

2017-12-18T03:34:28Z

← Older revision		Revision as of 12:34, 18 December 2017
Line 51:		Line 51:
	\|-		\|-
	\|rowspan="6"\| Ceramide synthase		\|rowspan="6"\| Ceramide synthase
	\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/>(LASS1,LAG1)		\| [http://www.uniprot.org/uniprot/P27544 CERS1]<br/> (LASS1, LAG1)
	\| 19p13.11		\| 19p13.11
	\| Brain, skeletal muscle, testis for C18		\| Brain, skeletal muscle, testis for C18
	\|-		\|-
	\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/>(LASS2,TMSG1)		\| [http://www.uniprot.org/uniprot/Q96G23 CERS2]<br/> (LASS2, TMSG1)
	\| 1q21.3		\| 1q21.3
	\| Kidney, liver and other >12 organs for C20-C26		\| Kidney, liver and other >12 organs for C20-C26