LBF20207PG25 - Revision history

Editor at 00:00, 17 January 2014

2014-01-17T00:00:00Z

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 |Biological Activity=Prostaglandin F2 alpha  exhibits various biological activities such as uterine contraction, gastrointestinal contraction, bronchoconstriction, luteolysis and vasoconstriction [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1|{{RelationTable/GetFirstAuthor|Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1}}]]. Prostaglandin F2 alpha  is a ligand to a receptor (FP) present in the cell membrane [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109|{{RelationTable/GetFirstAuthor|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].
 |Genetic Information=cDNA for prostaglandin F synthase was cloned from bovine lung [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257|{{RelationTable/GetFirstAuthor|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]]. cDNA for prostaglandin F2 alpha  receptor (FP) was cloned, and its 7ptransmembrane structure was reported [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109|{{RelationTable/GetFirstAuthor|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].
 }}
 {{Lipid/Footer}}

Editor at 08:30, 21 October 2010

2010-10-21T08:30:38Z

← Older revision		Revision as of 17:30, 21 October 2010
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	\|LipidBank=XPR1501		\|LipidBank=XPR1501
	\|LipidMaps=LMFA03010002		\|LipidMaps=LMFA03010002
	\|SysName=7- [ (3R,5S) -Dihydroxy-2R - (3S -hydroxy-1~~-trans~~-octenyl) cyclopentan-1R -yl ] -5~~-cis~~-heptenoic acid		\|SysName=7- [ (3R,5S) -Dihydroxy-2R - (3S -hydroxy-trans-1-octenyl) cyclopentan-1R -yl] -cis-5-heptenoic acid
	\|Common Name=&&Prostaglandin F_2 alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&		\|Common Name=&&Prostaglandin F_2 alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]

Editor at 07:23, 9 June 2010

2010-06-09T07:23:25Z

← Older revision		Revision as of 16:23, 9 June 2010
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	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]
	\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]		\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]
	\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]		\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]
	\|IR Spectra=NEAT : 3320, 2640, 1710, 1295, 1260, 1245, 1120, 1080, 1055, 1025, 975cm^{-1} [[Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]		\|IR Spectra=NEAT : 3320, 2640, 1710, 1295, 1260, 1245, 1120, 1080, 1055, 1025, 975cm^{-1} [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:PikeJ_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]
	\|NMR Spectra=^1 H-NMR(d_6 -ACETONE) : delta 5.48(m, 4H), 4.05(m, 3H), 0.9(t, 3H, 20-CH3) [[Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. ^{13}C-NMR : 176.6(C1), 135.0(C14), 132.8(C5), 129.1(C13 or C6), 128.9(C6 or C13), 77.2(C11), 72.9(C15), 71.8(C9), 55.0(C12), 49.9(C8), 42,6(C10), 36.8(C16), 33.2(C2), 31,5(C18), 26.3(C4), 25.1(C7), 25.1(C17), 24.5 [[Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515\|{{RelationTable/GetFirstAuthor\|Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515}}]]		\|NMR Spectra=^1 H-NMR(d_6 -ACETONE) : delta 5.48(m, 4H), 4.05(m, 3H), 0.9(t, 3H, 20-CH3) [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. ^{13}C-NMR : 176.6(C1), 135.0(C14), 132.8(C5), 129.1(C13 or C6), 128.9(C6 or C13), 77.2(C11), 72.9(C15), 71.8(C9), 55.0(C12), 49.9(C8), 42,6(C10), 36.8(C16), 33.2(C2), 31,5(C18), 26.3(C4), 25.1(C7), 25.1(C17), 24.5 [[Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515\|{{RelationTable/GetFirstAuthor\|Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515}}]]
	\|Source=Prostaglandin F2 alpha was found to be accummulating in human semen in an amount of about 2 microgram per ml [[Reference:Bergstrom_S:,Science,1967,157,382\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:,Science,1967,157,382}}]]. In most animal tissues prostanoids are synthesized enzymatically de novo upon physiological and pathological stimulations, and this is also the case of prostaglandin F2 alpha .		\|Source=Prostaglandin F2 alpha was found to be accummulating in human semen in an amount of about 2 microgram per ml [[Reference:Bergstrom_S:,Science,1967,157,382\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:,Science,1967,157,382}}]]. In most animal tissues prostanoids are synthesized enzymatically de novo upon physiological and pathological stimulations, and this is also the case of prostaglandin F2 alpha .
	\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}		\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}

Editor at 01:06, 3 June 2010

2010-06-03T01:06:39Z

← Older revision		Revision as of 10:06, 3 June 2010
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	\|LipidMaps=LMFA03010002		\|LipidMaps=LMFA03010002
	\|SysName=7- [ (3R,5S) -Dihydroxy-2R - (3S -hydroxy-1-trans-octenyl) cyclopentan-1R -yl ] -5-cis-heptenoic acid		\|SysName=7- [ (3R,5S) -Dihydroxy-2R - (3S -hydroxy-1-trans-octenyl) cyclopentan-1R -yl ] -5-cis-heptenoic acid
	\|Common Name=&&Prostaglandin ~~F_2alpha~~&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&		\|Common Name=&&Prostaglandin F_2 alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]

Editor at 03:39, 27 May 2010

2010-05-27T03:39:04Z

← Older revision		Revision as of 12:39, 27 May 2010
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	\|LipidBank=XPR1501		\|LipidBank=XPR1501
	\|LipidMaps=LMFA03010002		\|LipidMaps=LMFA03010002
	\|SysName=7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -~~octenylcyclopentan~~-1 (R) -yl ] -5 (Z) -heptenoic acid		\|SysName=7- [ (3R,5S) -Dihydroxy-2R - (3S -hydroxy-1-trans-octenyl) cyclopentan-1R -yl ] -5-cis-heptenoic acid
	~~\|Common Name=&&Prostaglandin F_2alpha~~&&		\|Common Name=&&Prostaglandin F_2alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]

Editor at 04:40, 23 April 2010

2010-04-23T04:40:46Z

← Older revision		Revision as of 13:40, 23 April 2010
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	\|LipidMaps=LMFA03010002		\|LipidMaps=LMFA03010002
	\|SysName=7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid		\|SysName=7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid
	\|Common Name=&&~~PROSTAGLANDIN~~ F_2alpha&&		\|Common Name=&&Prostaglandin F_2alpha&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]

Editor at 09:12, 15 April 2010

2010-04-15T09:12:43Z

← Older revision		Revision as of 18:12, 15 April 2010
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	\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}		\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}
	\|Metabolism=Prostaglandin F synthase reduces 9,11-endoperoxide of prostaglandin H2 requiring NADPH, and produces prostaglandin F2 alpha . The same enzyme also reduces 9-keto group of prostaglandin D2 producing 11 beta -prostaglandin F2 [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]].		\|Metabolism=Prostaglandin F synthase reduces 9,11-endoperoxide of prostaglandin H2 requiring NADPH, and produces prostaglandin F2 alpha . The same enzyme also reduces 9-keto group of prostaglandin D2 producing 11 beta -prostaglandin F2 [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]].
	\|Symbol=PGF2 α		\|Symbol=PGF2α
	\|Biological Activity=Prostaglandin F2 alpha exhibits various biological activities such as uterine contraction, gastrointestinal contraction, bronchoconstriction, luteolysis and vasoconstriction [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1}}]]. Prostaglandin F2 alpha is a ligand to a receptor (FP) present in the cell membrane [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].		\|Biological Activity=Prostaglandin F2 alpha exhibits various biological activities such as uterine contraction, gastrointestinal contraction, bronchoconstriction, luteolysis and vasoconstriction [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1}}]]. Prostaglandin F2 alpha is a ligand to a receptor (FP) present in the cell membrane [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].
	\|Genetic Information=cDNA for prostaglandin F synthase was cloned from bovine lung [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]]. cDNA for prostaglandin F2 alpha receptor (FP) was cloned, and its 7ptransmembrane structure was reported [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].		\|Genetic Information=cDNA for prostaglandin F synthase was cloned from bovine lung [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]]. cDNA for prostaglandin F2 alpha receptor (FP) was cloned, and its 7ptransmembrane structure was reported [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].

Editor at 09:12, 15 April 2010

2010-04-15T09:12:20Z

← Older revision		Revision as of 18:12, 15 April 2010
Line 17:		Line 17:
	\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}		\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}
	\|Metabolism=Prostaglandin F synthase reduces 9,11-endoperoxide of prostaglandin H2 requiring NADPH, and produces prostaglandin F2 alpha . The same enzyme also reduces 9-keto group of prostaglandin D2 producing 11 beta -prostaglandin F2 [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]].		\|Metabolism=Prostaglandin F synthase reduces 9,11-endoperoxide of prostaglandin H2 requiring NADPH, and produces prostaglandin F2 alpha . The same enzyme also reduces 9-keto group of prostaglandin D2 producing 11 beta -prostaglandin F2 [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]].
	\|Symbol=PGF2 alpha		\|Symbol=PGF2 α
	\|Biological Activity=Prostaglandin F2 alpha exhibits various biological activities such as uterine contraction, gastrointestinal contraction, bronchoconstriction, luteolysis and vasoconstriction [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1}}]]. Prostaglandin F2 alpha is a ligand to a receptor (FP) present in the cell membrane [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].		\|Biological Activity=Prostaglandin F2 alpha exhibits various biological activities such as uterine contraction, gastrointestinal contraction, bronchoconstriction, luteolysis and vasoconstriction [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1}}]]. Prostaglandin F2 alpha is a ligand to a receptor (FP) present in the cell membrane [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].
	\|Genetic Information=cDNA for prostaglandin F synthase was cloned from bovine lung [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]]. cDNA for prostaglandin F2 alpha receptor (FP) was cloned, and its 7ptransmembrane structure was reported [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].		\|Genetic Information=cDNA for prostaglandin F synthase was cloned from bovine lung [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257\|{{RelationTable/GetFirstAuthor\|Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257}}]]. cDNA for prostaglandin F2 alpha receptor (FP) was cloned, and its 7ptransmembrane structure was reported [[Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109\|{{RelationTable/GetFirstAuthor\|Reference:Negishi_M:Sugimoto_Y:Ichikawa_A:,Biochim. Biophys. Acta,1995,1259,109}}]].

Dbmanager at 21:00, 14 April 2010

2010-04-14T21:00:00Z

← Older revision		Revision as of 06:00, 15 April 2010
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	\|LipidMaps=LMFA03010002		\|LipidMaps=LMFA03010002
	\|SysName=7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid		\|SysName=7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid
	\|Common Name=&&PROSTAGLANDIN F_2alpha~~&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid~~&&		\|Common Name=&&PROSTAGLANDIN F_2alpha&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]

Dbmanager at 05:47, 26 February 2010

2010-02-26T05:47:59Z

← Older revision		Revision as of 14:47, 26 February 2010
Line 9:		Line 9:
	\|Common Name=&&PROSTAGLANDIN F_2alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&		\|Common Name=&&PROSTAGLANDIN F_2alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]X^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]
	\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]		\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]
	\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]		\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]

← Older revision		Revision as of 16:23, 9 June 2010
Line 10:		Line 10:
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]
	\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]		\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]
	\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]		\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]
	\|IR Spectra=NEAT : 3320, 2640, 1710, 1295, 1260, 1245, 1120, 1080, 1055, 1025, 975cm^{-1} [[Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]		\|IR Spectra=NEAT : 3320, 2640, 1710, 1295, 1260, 1245, 1120, 1080, 1055, 1025, 975cm^{-1} [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:PikeJ_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]
	\|NMR Spectra=^1 H-NMR(d_6 -ACETONE) : delta 5.48(m, 4H), 4.05(m, 3H), 0.9(t, 3H, 20-CH3) [[Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:~~Pike_J_E~~:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. ^{13}C-NMR : 176.6(C1), 135.0(C14), 132.8(C5), 129.1(C13 or C6), 128.9(C6 or C13), 77.2(C11), 72.9(C15), 71.8(C9), 55.0(C12), 49.9(C8), 42,6(C10), 36.8(C16), 33.2(C2), 31,5(C18), 26.3(C4), 25.1(C7), 25.1(C17), 24.5 [[Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515\|{{RelationTable/GetFirstAuthor\|Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515}}]]		\|NMR Spectra=^1 H-NMR(d_6 -ACETONE) : delta 5.48(m, 4H), 4.05(m, 3H), 0.9(t, 3H, 20-CH3) [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. ^{13}C-NMR : 176.6(C1), 135.0(C14), 132.8(C5), 129.1(C13 or C6), 128.9(C6 or C13), 77.2(C11), 72.9(C15), 71.8(C9), 55.0(C12), 49.9(C8), 42,6(C10), 36.8(C16), 33.2(C2), 31,5(C18), 26.3(C4), 25.1(C7), 25.1(C17), 24.5 [[Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515\|{{RelationTable/GetFirstAuthor\|Reference:Lukacs_G:Piriou_F:Gero_SD:,Tetrah. Lett.,1973,,515}}]]
	\|Source=Prostaglandin F2 alpha was found to be accummulating in human semen in an amount of about 2 microgram per ml [[Reference:Bergstrom_S:,Science,1967,157,382\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:,Science,1967,157,382}}]]. In most animal tissues prostanoids are synthesized enzymatically de novo upon physiological and pathological stimulations, and this is also the case of prostaglandin F2 alpha .		\|Source=Prostaglandin F2 alpha was found to be accummulating in human semen in an amount of about 2 microgram per ml [[Reference:Bergstrom_S:,Science,1967,157,382\|{{RelationTable/GetFirstAuthor\|Reference:Bergstrom_S:,Science,1967,157,382}}]]. In most animal tissues prostanoids are synthesized enzymatically de novo upon physiological and pathological stimulations, and this is also the case of prostaglandin F2 alpha .
	\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}		\|Chemical Synthesis=[[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]] {{Image200\|LBF20207PG25FT0001.gif}}

← Older revision		Revision as of 14:47, 26 February 2010
Line 9:		Line 9:
	\|Common Name=&&PROSTAGLANDIN F_2alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&		\|Common Name=&&PROSTAGLANDIN F_2alpha&&7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3 (S) -hydroxy-1 (E) -octenylcyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid&&
	\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]		\|Melting Point=25-35°C [[Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123\|{{RelationTable/GetFirstAuthor\|Reference:Bundy_GL:Schneider_WP:Lincoln_FH:Pike_JE:,J. Am. Chem. Soc.,1972,94,2123}}]]
	\|Optical=[ alpha ]X^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]		\|Optical=[ alpha ]^{25}_D =23.8 °(C=1,THF) [[Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397\|{{RelationTable/GetFirstAuthor\|Reference:Corey_EJ:Schaaf_TK:Huber_W:Koelliker_U:Weinshenker_NM:,J. Am. Chem. Soc.,1970,92,397}}]]
	\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]		\|Solubility= ETHYL ACETATE, ACETONE, DIETHYLETHER [[Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552\|{{RelationTable/GetFirstAuthor\|Reference:Pike_J_E:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552}}]]. STABILITIES: to be stable under neutral and basic conditions [[Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416\|{{RelationTable/GetFirstAuthor\|Reference:Karim_SM:Devlin_J:Hillier_K:,Eur. J. Pharmacol.,1968,4,416}}]]
	\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]		\|Mass Spectra=354(M^+ ), 336, 318, 292, 274, 264(100), 247, 229, 191, 177, 165, 137, 99, 81, 67 [[Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127\|{{RelationTable/GetFirstAuthor\|Reference:Horvath_G:,Biomed. Mass Spectrom.,1976,3,127}}]]