LBF20406LT13 - Revision history

Editor at 00:00, 17 January 2014

2014-01-17T00:00:00Z

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 |Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1|{{RelationTable/GetFirstAuthor|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355|{{RelationTable/GetFirstAuthor|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to Gi alpha /o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789|{{RelationTable/GetFirstAuthor|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
 |Genetic Information=cDNA for CysLT1 was cloned [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789|{{RelationTable/GetFirstAuthor|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
 }}
 {{Lipid/Footer}}

Editor at 07:54, 21 October 2010

2010-10-21T07:54:08Z

← Older revision		Revision as of 16:54, 21 October 2010
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	\|LipidBank=XPR3301		\|LipidBank=XPR3301
	\|LipidMaps=LMFA03020006		\|LipidMaps=LMFA03020006
	\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (7-~~trans~~,9-~~trans~~,11-~~cis,~~14~~-cis~~) -eicosatetraenoic acid		\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (trans-7,trans-9,cis-11,cis-14) -eicosatetraenoic acid
	\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&		\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]

Editor at 07:46, 2 June 2010

2010-06-02T07:46:42Z

← Older revision		Revision as of 16:46, 2 June 2010
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	\|LipidBank=XPR3301		\|LipidBank=XPR3301
	\|LipidMaps=LMFA03020006		\|LipidMaps=LMFA03020006
	\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (7-trans,9-trans,11-cis,14-cis) -~~icosatetraenoic~~ acid		\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (7-trans,9-trans,11-cis,14-cis) -eicosatetraenoic acid
	\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&		\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]

Editor at 01:28, 2 June 2010

2010-06-02T01:28:44Z

← Older revision		Revision as of 10:28, 2 June 2010
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	\|LipidBank=XPR3301		\|LipidBank=XPR3301
	\|LipidMaps=LMFA03020006		\|LipidMaps=LMFA03020006
	\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (7-trans,9-trans,11-cis,14-cis) -~~eicosatetraenoic~~ acid		\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (7-trans,9-trans,11-cis,14-cis) -icosatetraenoic acid
	\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&		\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]

Editor at 01:01, 2 June 2010

2010-06-02T01:01:24Z

← Older revision		Revision as of 10:01, 2 June 2010
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	\|LipidBank=XPR3301		\|LipidBank=XPR3301
	\|LipidMaps=LMFA03020006		\|LipidMaps=LMFA03020006
	\|SysName=5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid		\|SysName=5S-Hydroxy-6R-S-cysteinylglycinyl- (7-trans,9-trans,11-cis,14-cis) -eicosatetraenoic acid
	~~\|Common Name=&&LEUKOTRIENE D4~~&&		\|Common Name=&&Leukotriene D_4&&5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]

Editor at 21:00, 14 April 2010

2010-04-14T21:00:00Z

← Older revision		Revision as of 06:00, 15 April 2010
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	\|LipidMaps=LMFA03020006		\|LipidMaps=LMFA03020006
	\|SysName=5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid		\|SysName=5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid
	\|Common Name=&&LEUKOTRIENE D4~~&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid~~&&		\|Common Name=&&LEUKOTRIENE D4&&
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]

Editor at 10:00, 25 February 2010

2010-02-25T10:00:10Z

← Older revision		Revision as of 19:00, 25 February 2010
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	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|UV Spectra= lambda ^~~M_m _a _x~~ = 270( epsilon 32,000), 280( epsilon 40,000), 290( epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]		\|UV Spectra= lambda ^{MeOH}_{max} = 270( epsilon 32,000), 280( epsilon 40,000), 290( epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]
	\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].		\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].
	\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}		\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}

Editor at 14:00, 19 February 2010

2010-02-19T14:00:10Z

← Older revision		Revision as of 23:00, 19 February 2010
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	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|UV Spectra=lambda ^M_m _a _x = 270(epsilon 32,000), 280(epsilon 40,000), 290(epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]		\|UV Spectra= lambda ^M_m _a _x = 270( epsilon 32,000), 280( epsilon 40,000), 290( epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]
	\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].		\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].
	\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}		\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}
	\|Metabolism= gamma-Glutamyl transpeptidase hydrolyzes the glutathione moiety of leukotriene C4 and produces leukotriene D4 liberating glutamic acid [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]],		\|Metabolism= gamma -Glutamyl transpeptidase hydrolyzes the glutathione moiety of leukotriene C4 and produces leukotriene D4 liberating glutamic acid [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]],
	\|Symbol=LTD4		\|Symbol=LTD4
	\|Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to ~~Gialpha~~/o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].		\|Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to Gi alpha /o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
	\|Genetic Information=cDNA for CysLT1 was cloned [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].		\|Genetic Information=cDNA for CysLT1 was cloned [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
	}}		}}

	{{Lipid/Footer}}		{{Lipid/Footer}}

Editor at 14:00, 19 February 2010

2010-02-19T14:00:00Z

← Older revision		Revision as of 23:00, 19 February 2010
Line 9:		Line 9:
	\|Common Name=&&LEUKOTRIENE D4&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&		\|Common Name=&&LEUKOTRIENE D4&&5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid&&
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M~~<SUP><FONT SIZE=-1>~~+~~</FONT></SUP>~~), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|UV Spectra=<FONT FACE="Symbol">l</FONT> <SUP><FONT SIZE=-1>M</FONT></SUP><SUP><FONT SIZE=-1>e</FONT></SUP><SUP><FONT SIZE=-1>O</FONT></SUP><SUP><FONT SIZE=-1>H</FONT></SUP><SUB><FONT SIZE=-1>m</FONT></SUB><SUB><FONT SIZE=-1>a</FONT></SUB><SUB><FONT SIZE=-1>x</FONT></SUB> = 270(~~<FONT FACE="Symbol">e</FONT>~~ 32,000), 280(~~<FONT FACE="Symbol">e</FONT>~~ 40,000), 290(~~<FONT FACE="Symbol">e</FONT>~~ 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]		\|UV Spectra=lambda ^M_m _a _x = 270(epsilon 32,000), 280(epsilon 40,000), 290(epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]
	\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].		\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].
	\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}		\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}
	\|Metabolism= ~~<FONT FACE="Symbol">g</FONT>~~-Glutamyl transpeptidase hydrolyzes the glutathione moiety of leukotriene C4 and produces leukotriene D4 liberating glutamic acid [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]],		\|Metabolism= gamma-Glutamyl transpeptidase hydrolyzes the glutathione moiety of leukotriene C4 and produces leukotriene D4 liberating glutamic acid [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]],
	\|Symbol=LTD4		\|Symbol=LTD4
	\|Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to ~~Gi<FONT FACE="Symbol">a</FONT>~~/o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].		\|Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to Gialpha/o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
	\|Genetic Information=cDNA for CysLT1 was cloned [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].		\|Genetic Information=cDNA for CysLT1 was cloned [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
	}}		}}

	{{Lipid/Footer}}		{{Lipid/Footer}}

Editor at 17:00, 27 January 2010

2010-01-27T17:00:00Z

← Older revision		Revision as of 02:00, 28 January 2010
Line 16:		Line 16:
	\|Symbol=LTD4		\|Symbol=LTD4
	\|Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to Gi<FONT FACE="Symbol">a</FONT>/o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].		\|Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]]. Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to Gi<FONT FACE="Symbol">a</FONT>/o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
			\|Genetic Information=cDNA for CysLT1 was cloned [[Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789\|{{RelationTable/GetFirstAuthor\|Reference:Lynch_KR:ONeill_GP:Liu_Q:Im_DS:Sawyer_N:Metters_KM:Coulombe_N:Abramovitz_M:Figueroa_DJ:Zeng_Z_et_al:,Nature,1999,399,789}}]].
	}}		}}

	{{Lipid/Footer}}		{{Lipid/Footer}}

← Older revision		Revision as of 19:00, 25 February 2010
Line 10:		Line 10:
	\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Solubility=METHANOL [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]		\|Mass Spectra=N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M^+ ), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 [[Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601\|{{RelationTable/GetFirstAuthor\|Reference:Morris_HR:Taylor_GW:Rokach_J:Girard_Y:Piper_PJ:Tippins_JR:Samhoun_MN:,Prostaglandins,1980,20,601}}]]
	\|UV Spectra= lambda ^~~M_m _a _x~~ = 270( epsilon 32,000), 280( epsilon 40,000), 290( epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]		\|UV Spectra= lambda ^{MeOH}_{max} = 270( epsilon 32,000), 280( epsilon 40,000), 290( epsilon 31,000)nm [[Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710\|{{RelationTable/GetFirstAuthor\|Reference:Lewis_RA:Austen_KF:Drazen_JM:Clark_DA:Marfat_A:Corey_EJ:,Proc. Natl. Acad. Sci. U. S. A.,1980,77,3710}}]]
	\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].		\|Source=Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1\|{{RelationTable/GetFirstAuthor\|Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1}}]][[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355\|{{RelationTable/GetFirstAuthor\|Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355}}]].
	\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}		\|Chemical Synthesis=[[Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661\|{{RelationTable/GetFirstAuthor\|Reference:Cohen_N:Banner_BL:Lopresti_RJ:Wong_F:Rosenberger_M:Liu_YY:Thom_E:Liebman_AA:,J. Am. Chem. Soc.,1983,105,3661}}]] {{Image200\|LBF20406LT13FT0001.gif}}