https://lipidbank.jp/mediawiki/index.php?action=history&feed=atom&title=LBF22408AM02 2026-04-30T21:48:55Z Revision history for this page on the wiki MediaWiki 1.43.0 https://lipidbank.jp/mediawiki/index.php?title=LBF22408AM02&diff=56784&oldid=prev 2010-10-22T07:14:40Z

<p>New page: {{Lipid/Header}} {{Hierarchy|{{PAGENAME}}}} {{Metabolite |LipidBank=XPR7057 |LipidMaps=LMFA08020043 |SysName=N- (2R-Methyl-3-hydroxy-ethyl) -16,16-dimethyl- (cis-5,cis-8,cis-11,cis-14) -...</p> <p><b>New page</b></p><div>{{Lipid/Header}}<br /> <br /> {{Hierarchy|{{PAGENAME}}}}<br /> <br /> {{Metabolite<br /> |LipidBank=XPR7057<br /> |LipidMaps=LMFA08020043<br /> |SysName=N- (2R-Methyl-3-hydroxy-ethyl) -16,16-dimethyl- (cis-5,cis-8,cis-11,cis-14) -docosatetraenoyl amine<br /> |Common Name=&amp;&amp;N- (2R-Methyl-3-hydroxy-ethyl) -16,16-dimethyl- (5Z,8Z,11Z,14Z) -docosatetraenoylamine&amp;&amp;(R) - 16,16-Dimethyldocosa- (5Z,8Z,11Z,14Z) -tetraenoyl-1&#039;-hydroxy-2&#039;-propylamine&amp;&amp;<br /> |NMR Spectra=^1 H NMR (CDCl3) delta 5.73 (br d, 1H, J=6.5Hz, NH), 5.36 (m, 6H, 5,6,8,9,11,12-vinyl-H), 5.21 (m, 2H, 14,15-vinyl-H), 4.04 (m, lH, N-CH), 3.64 (br m, 1H, OCH3), 3.52 (br m, 1H, OCH&#039;), 3.18 (br s, 1H, OH), 2.91 (t, 2H, J=5.9Hz, 13-CH2), 2.79 (m, 4H, 7,10-CH2), 2.18 (t, 2H, J=7.6Hz,2-CH2), 2.08 (m, 2H, 4-CH2), 1.71 (p, 2H, J=7.4 Hz, 3-CH2), 1.27 (m, 10H, 17-21-CH2), 1.15 (d, 3H, J=6.8Hz, N-C-CH3), 1.08 (s, 6H, gem-Me2), 0.86 (m, 3H, 22-CH3) [[Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626|{{RelationTable/GetFirstAuthor|Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626}}]]<br /> |Source=<br /> |Chemical Synthesis=(R)-(16,16-Dimethyldocosa-cis-5,8,11,14-tetraenoic methyl ester (methyl alcohol solution), NaCN and (R)-(-)-2-amino-1-propanol are heated at 50°C overnight in a sealed tube. Yield 77%. [[Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626|{{RelationTable/GetFirstAuthor|Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626}}]]<br /> |Metabolism=<br /> |Biological Activity={{Image200|LBF20408AM02FT7057.gif}} [[Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626|{{RelationTable/GetFirstAuthor|Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626}}]]<br /> }}<br /> <br /> {{Lipid/Footer}}</div>

Editor