https://lipidbank.jp/mediawiki/index.php?action=history&feed=atom&title=LBF22408AM03 2026-04-30T21:42:58Z Revision history for this page on the wiki MediaWiki 1.43.0 https://lipidbank.jp/mediawiki/index.php?title=LBF22408AM03&diff=56785&oldid=prev 2010-10-22T07:16:24Z

<p>New page: {{Lipid/Header}} {{Hierarchy|{{PAGENAME}}}} {{Metabolite |LipidBank=XPR7058 |LipidMaps=LMFA08020044 |SysName=N- (2-Hydroxy-2S-methyl-ethyl) -16,16-dimethyl- (cis-5,cis-8,cis-11,cis-14) -...</p> <p><b>New page</b></p><div>{{Lipid/Header}}<br /> <br /> {{Hierarchy|{{PAGENAME}}}}<br /> <br /> {{Metabolite<br /> |LipidBank=XPR7058<br /> |LipidMaps=LMFA08020044<br /> |SysName=N- (2-Hydroxy-2S-methyl-ethyl) -16,16-dimethyl- (cis-5,cis-8,cis-11,cis-14) -docosatetraenoylamine<br /> |Common Name=&amp;&amp;N- (2-Hydroxy-2S-methyl-ethyl) -16,16-dimethyl- (5Z,8Z,11Z,14Z) -docosatetraenoylamine&amp;&amp;(S) - (16,16-Dimethyldocosa- (5Z,8Z,11Z,14Z) -tetraenoyl) -2&#039;-hydroxy-1&#039;-propylamine&amp;&amp;<br /> |NMR Spectra=^1 H NMR (CDCl3) delta 5.99 (br s, 1H, NH), 5.36 (m, 6H, 5,6,8,9,11,12-vinyl-H), 5.18 (m, 2H,14,15-vinyl-H), 3.89 (m, 1H, O-CH), 3.42 (m, 1H, NCH), 3.10 (m, 1H, NCH&#039;), 2.92 (t,2H, J=6.1Hz, 13-CH2), 2.81 (m, 4H, 7,10-CH2), 2.21 (t, 2H, J=7.6Hz, 2-CH2), 2.09 (m, 2H, 4-CH2), 1.71 (p, 2H, J=7.5Hz, 3-CH2), 1.25 (br, m, 10H, 17-21-CH2), 1.18 (d, 3H, J=6.3Hz, O-C-CH3), 1.08 (s, 6H, gem-Me2), 0.87 (m, 3H, 22-CH39) [[Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626|{{RelationTable/GetFirstAuthor|Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626}}]]<br /> |Source=<br /> |Chemical Synthesis=A methanol solution of the corresponding ester , NaCN and (S)-(+)-1-amino-2-propanol are heated 2-days in a hot block at 50°C. Yield 65%. [[Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626|{{RelationTable/GetFirstAuthor|Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626}}]]<br /> |Metabolism=<br /> |Biological Activity={{Image200|LBF20408AM03FT7058.gif}} [[Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626|{{RelationTable/GetFirstAuthor|Reference:Seltzman_HH:Fleming_DN:Thomas_BF:Gilliam_AF:McCallion_DS:Pertwee_RG:Compton_DR:Martin_BR:,J. Med. Chem.,1997,40,3626}}]]<br /> }}<br /> <br /> {{Lipid/Footer}}</div>

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