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[title] <2.5,2.5> #Ceramide Biosynthesis //titles [ER] <6.83,66.82>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Endoplasmic reticulum [Cytosol] <70,1>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Cytosol [PlasmaMembraneName] <91.51,4.97>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Plasma Membrane [LysosomeName] <82.14..."

2023-11-29T03:59:09Z

Created page with "<div id="source" style="display:none"> <nowiki> [title] <2.5,2.5> #Ceramide Biosynthesis //titles [ER] <6.83,66.82>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Endoplasmic reticulum [Cytosol] <70,1>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Cytosol [PlasmaMembraneName] <91.51,4.97>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Plasma Membrane [LysosomeName] <82.14..."

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<nowiki>
[title] <2.5,2.5>
#Ceramide Biosynthesis

//titles
[ER] <6.83,66.82>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
Endoplasmic reticulum

[Cytosol] <70,1>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
Cytosol

[PlasmaMembraneName] <91.51,4.97>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
Plasma Membrane

[LysosomeName] <82.14,16.54>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
Lysosome

[cisGLD] <24.68,41.48>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
cis/medial Golgi

[transGLD] <44.10,41.48>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
trans Golgi

[TGNName] <71.40,41.48>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2)
trans Golgi network

//========================================Organelle boxes========================

[ER1] <3.89,0.66,166.03,1024.31>css(background:rgb(200,255,10;border-right:50px solid rgb(200,200,0;box-shadow:none;z-index:1)
[ER2] <11.03,52.92,1280.14,340.00>css(background:rgb(200,255,10;border-top:50px solid rgb(200,200,0;box-shadow:none;z-index:1)
[ER3] <3.84,53.16,165.38,333.00>css(background:rgb(200,255,10;box-shadow:none;z-index:1)

[PlasmaMembrane] <94.81,1.10,51.19,1154.37>css(background:rgb(100,100,100;box-shadow:none;z-index:1;)

//Golgi
[Golgi] <24.81,20.95,162.20,324.15>css(background:rgb(50,140,140;border:30px solid rgb(100,200,200;box-shadow:none;z-index:1)

//Golgi
[Golgi_trans] <35.84,20.95,404.71,324.15>css(background:rgb(50,140,140;border:30px solid rgb(100,200,200;box-shadow:none;z-index:1)

//Trans Golgi network
[TGN] <63.40,20.95,404.71,324.15>css(background:rgb(50,140,140;border:30px solid rgb(100,200,200;box-shadow:none;z-index:1)

//Lysosome
[Lysosome] (mark) <77.73,0.56,170.61,255.93>css(background:rgb(130,140,140;border:30px solid rgb(130,180,180;box-shadow:none;z-index:1)

//=========================================Metabolites=====================================================
//Palmitoyl-CoA
[PalCoA] <12.68,1.66>
PalCoA
d=(l_w3)=>u[3KDS]

//3-ketodihydrosphingosine
[3KDS] <12.68,7.17>
3-KDS
d=(l_w3)=>u[DHS]

//dihydrosphingosine
[DHS] <13.23,12.68>
DHS
d=(l_w3)=>u[DHC]

//dihydroceramide
[DHC] <13.23,17.64>
DHC
d=(l_w3)=>u[Cer]

//Ceramide
[C1P] <66.71,15.44>
!SP{O-PO3}
C1P
r=(l_w)=>[PlasmaMembrane]

//Ceramide
[Cer] <12.13,23.15>
!SP{O}
Cer
r=(l_w3)=>u[GlcCer]
r=(l_w3)=l[CERT]

//Ceramide
[Cer2] <38.33,25.73>
Cer
u=(l_w3)=>u[SM]

//Ceramide
[Cer3] <56.18,18.90>
Cer

//Ceramide
[Cer4] <63.95,18.19>
Cer
d=(l_w3)=>d[C1P]

//Ceramide
[Cer5] <13.79,45.76>
Cer

//Ceramide
[Cer6] <52.92,51.82>
Cer

//Ceramide
[Cer7] <97.02,19.30>
Cer
u=(l_w3)=>d[SM4]

//Ceramide
[Cer8] <80.48,4.97>
Cer

//Ceramide
[Cer9] <79.94,11.03>
Cer

//Sphingosine
[Sph] <13.23,32.53>
Sph
u=(l_w3)=>d[Cer]

//Glucosylceramide
[GlcCer] <19.30,29.77>
!SP{O-Glc}
GlcCer
d=(l_w3)=>[GlcCer2]
d=(l_w3)=l[FAPP2]
d=(l_w3)=>u[Cer5]

//Glucosylceramide
[GlcCer2] <28.12,35.84>
GlcCer
r=(l_w3)=>l[GlcCer3]

//Glucosylceramide
[GlcCer3] <38.33,35.18>
GlcCer
d=(l_w3)=>l[LacCer]

//Glucosylceramide
[GlcCer4] <66.71,38.04>
GlcCer
l=(l_w3)=>L[LacCer2]

//Glucosylceramide
[GlcCer5] <83.79,11.03>
GlcCer
d=(l_w3)=>d[Cer9]

//Lactosylceramide
[LacCer] <46.5,36>
!SP{O-Glc-Gal}
LacCer
r=(l_w3)=>r[GM3]

//Lactosylceramide
[LacCer2] <67,32.5>
!SP{O-Glc-Gal}
LacCer
l=(l_w3)=>L[GB3]
d=(l_w3)=>d[GA2]

//Globotriaosylceramide
[GB3] <66.5,27.5>
!SP{O-Glc-Gal-Gal}
Gb3
r=(l_w)=>[PlasmaMembrane]

//Globoside
[GA2] <76.07,34.73>
!SP{O-Glc-Gal-GalNAc}
GA2
r=(l_w)=>[PlasmaMembrane]

//asialoGM１
[GM3] <45.15,30.45>
!SP{O-Glc-Gal| SA}
GM3

//asialoGM 3
[GM2] <71.5,22.5>
!SP{O-Glc-Gal-GalNAc| SA|}
GM2
r=(l_w)=>[PlasmaMembrane]

//GM1
[SM] <43.05,25.20>
!SP{O-Choline}
SM
r=(l_w3)=>d[Cer3]

//Sphingomyelin
[SM2] <64.50,51.82>
SM
l=(l_w3)=>r[Cer6]

//Sphingomyelin
[SM3] <100.33,26.46>
SM
u=(l_w3)=>d[Cer7]

//Sphingomyelin
[SM4] <96.47,12.13>
SM

//Sphingomyelin
[SM5] <84.35,4.97>
SM
u=(l_w3)=>u[Cer8]
//===============================================gene========================================
//serine palmitoyl transferase
[SPT] <13.23,3.86>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
SPT

//3-ketodihydrosphingosine reductase
[KDSR] <12.68,9.38>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
KDSR

//ceramide synthase
[CerS] <12.68,14.33>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
CerS

//ceramide synthase
[CerS2] <12.68,29.22>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
CerS

//dihydroceramide Δ4-desaturase
[DES] <12.68,19.84>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
DES

//UDP-glucose:ceramide glucosyltransferase
[UGCG] <21.50,26.46>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
UGCG

//Unknown Gene
[Ugen] <24.81,35.84>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
?

//Unknown Gene
[Ugen2] <63.95,39.69>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
?

//Unknown Gene
[Ugen3] <38.33,19.95>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
?

//β-1,4-galactosyltransferase5 and 6
[B4GalT5] <39.38,37.80>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
B4GalT5

//β-1,4-galactosyltransferase5 and 6
[B4GalT5-2] <62.84,36.38>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
B4GalT5

//ST3β-galactoside α-2,3-sialyltransferase 5
[ST3GalT5] <56.23,34.18>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
ST3GalT5

//Sphingomyelin synthase 1
[SMS1] <42.00,22.05>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
SMS1

//Sphingomyelin synthase 2
[SMS2] <95.37,15.44>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
SMS2

//neutral SMase 2
[NSMase2] <53.55,21.53>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
NSMase 2

//neutral SMase 2
[NSMase1] <57.33,51.27>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
NSMase 1

//four-phosphate adaptor protein 2
[FAPP2] <24.81,45.76>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
transferred by FAPP2
r=(l_w3)=>d[GlcCer4]

//α-1,4-galactosyltransferase
[A4GalT] <62.30,31.97>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
A4GalT

//β-1,4-N-acetylgalactosaminyltransferase 1 (GM2/GD2 synthase)
[B4GalNT1] <72.5,39>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
B4GalNT1

//ceramide transfer protein
[CERT] <33.08,15.23>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
transferred by CERT
d=(l_w3)=>u[Cer2]
r=(l_w3)=>l[Cer4]

//ceramidekinase
[CERK] <66.71,20.40>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
CERK

//β-glucosidases 1
[GBA1] <81.59,13.23>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
GBA1

//β-glucosidases 2
[GBA2] <12.68,42.45>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
GBA2

//acidic SMase
[ASMase] <98.12,23.15>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
ASMase

//acidic SMase
[ASMase2] <81.59,1.66>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5)
ASMase

</nowiki>
</div>
<div id="mainTxt" style="height:800px;"> </div>

PathwayMap:CeramideBiosynthesis - Revision history