PathwayMap:GlycerolipidBiosynthesis

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[title] <2.5,2.5> #Glycerolipid Metabolome de novo pathway of glycerophospholipid //Glycerol-3-phosphate acyltransferase g[GPAM] GPAT <span> Protein Glycerol-3-phosphate acyltransferase <br> Subcellular location GPAT1,2:Mitochondrion GPAT3,4:ER ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.3.1.15"KEGG") UniPlot <a href=http://www.uniprot.org/uniprot/Q9SHJ5>1</a>, <a href=http://www.uniprot.org/uniprot/Q9SHJ5>2</a>, <a href=http://www.uniprot.org/uniprot/Q9SHJ5>3</a>, <a href=http://www.uniprot.org/uniprot/Q9SHJ5>4</a> </span> [ERtext] (trans) <45.5,77.5>css(font-size:50px) Endoplasmic Reticulum [MTtext] (trans) <54,29.5>css(font-size:50px) Mitochondrion [ER] <2,3,350,1352>css(background:rgb(0,200,50 ; color:black; border-:100px; box-shadow:none;z-index:1;) ER [ER2] <22,37.5,1000,800>css(background:rgb(0,200,50; box-shadow:none;z-index:0;) [MT] <25,3,950,540>css(background:rgb(255,200,50 ; border-:100px; box-shadow:none;z-index:1;) //glycerol-3-phosphate [G3P] <9,8> !GL{OH |OH|O-PO_s3s_} ?[link](http://lipidbank.jp/cgi-bin/main.cgi?id=PGP "G3P") <pop> // glycerol-3-phosphate </pop> d=[GPAM](l_w3)=>u[LPA] //lysophosphatidic acid [LPA] <8,21.5> !GL{O-CO-R1|OH|O-PO_s3s_} LPA <pop> lysophosphatidic acid </pop> d=[AGPAT](l_w3)=>u[PA] //phosphatidic acid [PA] <8,32> !GL{O-CO-R1|O-CO-R1|O-PO_s3s_} ?[link](http://jcbl.jp/wiki/Volatile:ListMol?my_1=LBGPA"PA") d=[LPIN](l_w3)=>u[DAG] r=[CDS2](l_w3)=>l[CDP-DAG] r=[CDS1](l_w3)=>[CDP-DAGer] //diacylglycerol [DAG] <7.5,58.5> !GL{O-CO-R1|O-CO-R1| OH} DAG =[CHPT1](l_w3)=>[PC] =[CEPT1SELENOI](l_w3)=>[PE] //cytidine diphosphate-diacylglycerol [CDP-DAG] <27.5,26> !GL{O-CO-R1 | O-CO-R2 | O-PO2-CMP</t>} CDP-DAG u=[PGS1](l_w3)=>d[PGP] //cytidine diphosphate-diacylglycerol [CDP-DAGer] <28.5,39> !GL{O-CO-R1 | O-CO-R2 | O-PO2-CMP</t>} CDP-DAG r=[CDIPT](l_w3)=>[PI] //phosphatidylglycerol-phosphate [PGP] <27.5,9.5> !PG{O-CO-R1 | O-CO-R2 | O-PO2-O| HO|O3P-O} PGP =[PTPMT1] (l_w3)=>[PG] //phosphatidylglycerol [PG] <49,9.5> !PG{O-CO-R1 | O-CO-R2 | PO2-O| HO|HO } ?[link](http://jcbl.jp/wiki/Volatile:ListMol?my_1=LBGPG"PG") =[CRLS1](l_w3)=>[CL] //phosphatidylinositol [PI] <48,38.5> !GL{O-CO-R1 | O-CO-R2 | O-PO2-Inositol} ?[link](http://jcbl.jp/wiki/Volatile:ListMol?my_1=LBGPI"PI") //cardiolipin [CL] <70.5,8> !CL{O-CO-R1|O-CO-R2|O-PO-O|HO|O-PO-O|O-CO-R3| O-CO-R4} CL //phosphatidylcholine [PC] <26.5,51> !GL{O-CO-R1|O-CO-R1|O-PO2-Choline} ?[link](http://jcbl.jp/wiki/Volatile:ListMol?my_1=LBGPC"PC") d=[PTDSS](l_w3)=>u[PS] //phosphatidylethanolamine [PE] <25,75> !GL{O-CO-R1|O-CO-R1| O-PO2-Ethanolamine} ?[link](http://jcbl.jp/wiki/Volatile:ListMol?my_1=LBGPE "PE") u=[PTDSS]l(l_w3)=>d[PS] //phosphatidylserine [PS] (box) <26.5,62.5> !GL{O-CO-R1|O-CO-R1|O-PO2-Serine} ?[link](http://jcbl.jp/wiki/Volatile:ListMol?my_1=LBGPS "PS") d=[PISD]r(l_w3)=>u[PE] //1-acylglycerol-3-phosphate O-acyltransferase g[AGPAT] AGPAT //Phosphatidate cytidylyltransferase g[CDS2] CDS2 ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.7.41"KEGG") //Phosphatidate cytidylyltransferase g[CDS1] CDS1 ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.7.41"KEGG") //CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase g[PGS1] PGS ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.8.5 "KEGG") //Phosphatidylglycerophosphatase g[PTPMT1] PTPMT ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:3.1.3.27"KEGG") //cardiolipin synthase g[CRLS1] CRLS ?[link](http://www.uniprot.org/uniprot/Q9UJA2"UniProt") //Phosphatidate phosphatase g[LPIN] LPIN ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:3.1.3.4"KEGG") <pop> Phosphatidate phosphatase </pop> //Cholinephosphotransferase g[CHPT1] CHPT ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.8.2"KEGG") ?[link](http://www.uniprot.org/uniprot/Q8WUD6"UniProt") //Ethanolaminephosphotransferase 1 g[CEPT1SELENOI] CEPT1/SELENOI ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.8.1"KEGG") //Phosphatidylserine synthase g[PTDSS] PTDSS ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.8.8"KEGG") //Phosphatidylserine decarboxylase g[PISD] PISD ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:4.1.1.65"KEGG") //CDP-diacylglycerol--inositol 3-phosphatidyltransferase g[CDIPT] CDIPT ?[link](http://www.genome.jp/dbget-bin/www_bget?ec:2.7.8.11"KEGG") //Inositol [Inositol] <38,44.5> Inositol u==>u[CMP] //Inositol [CMP] <45,44.5> CMP //CTP [CTP] <17.5,29> CTP d==>d[PPi] //PPi [PPi] <22,27> PPi //H2O [H2O] <7,43.5> H2O r==>r[Pi] //Pi [Pi] <8,50.5> Pi //CDP-Ethanolamine [CDPethanolamine] <8.5,66> CDP-Ethanolamine r==>r[CMP2] //CMP [CMP2] <14.5,72> CMP //CDP-Choline [CDPcholine] <12.5,55> CDP-Choline r==>l[CMP3] //CMP [CMP3] <24.5,59.5> CMP //Serine [Serine] <34.5,57.5> Ser l==>l[Choline] //Choline [Choline] <34.5,60.5> Choline //CMP4 [CMP4] <66,16.5> CMP //CDP-DAG---CL [conect1] <59,16.5> CDP-DAG d=(l_w3)=r[CDP-DAG] u=(l_w3)=>u[CMP4] //H2O2 [H2O2] <40,10.5> H2O d==>d[Pi2] //Pi2 [Pi2] <44.5,10.5> Pi //glycerophosphate [glycerophosphate] <34.5,23.5> glycerophosphate l==>[CMP5] //CMP5 [CMP5] <34.5,20> CMP