Category:LBS
Sphingolipid (スフィンゴ脂質)
Class Overview
Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (2-amino-4-octadecene-1,3-diol). Sphingosine is further acylated to form ceramide, an important component of cell membranes.
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スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)で不飽和結合を1つ含んでいます (2-amino-4-octadecene-1,3-diol)。
スフィンゴシンがアシル化したものが、細胞膜の重要な成分であるセラミドです。
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Common Abbreviations よく使う略称
Cer | Ceramides | セラミド |
Sph | Sphingosine | スフィンゴシン |
Design of Sphingolipid Identifiers ID番号の設計
25-DIGIT(5+9+9+2)
L | B | S | a | a | : | x1 | x1 | y1 | z1 | z1 | w1 | w1 | c1 | c1 | : | x2 | x2 | y2 | z2 | z2 | w2 | w2 | c2 | c2 |
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Classification
By the Number of Sugars 糖の個数
For glycosphingolipid, 2 digits following LBS stand for the number of attached sugars. For phosphosphingolipid, the code of phosphorylation, PP. |
スフィンゴ糖脂質は結合している糖の総数をLBSに続く2桁の数字で、スフィンゴリン脂質は数字の代わりにリン酸化修飾を示す記号PPで分類しています。 |
Sphingolipid Overview | ||
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Polysaccharide Chain
Glycosphingolipids (Abbr. ROOT = Galβ1-4Glcβ1-Cer) | |||||||||||||||||
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Ganglio [G] (??) GalNAcβ1-4 ROOT |
Lacto [L] (??) GlcNAcβ1-3 ROOT |
Globo [B] (??) Galα1-4 ROOT |
Root [R] (??) derivatives of ROOT | ||||||||||||||
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Isoganglio [iG] (??) GalNAcβ1-3 ROOT |
Lacto with β1-6 [] (??) GlcNAcβ1-6 ROOT |
Isoglobo [iB] (??) Galα1-3 ROOT | |||||||||||||||
Lactoganglio [LG]
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Isogloboganglio
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Glycosphingolipids without ROOT | |||||||||||||||||||
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??? (??) Glcβ1-Cer |
Gala (??) Galβ1-Cer |
Phospho (??) Ino-P-Cer |
Others (??) | ||||||||||||||||
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