LBF17307HO01

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Upper classes: LB LBF



12S -Hydroxy- (5Z,8E,10Z) -heptadecatrienoic acid
LBF17307HO01.png
Structural Information
12S-Hydroxy- (cis-5,trans-8,cis-10) -heptadecatrienoic acid
  • 12S -Hydroxy- (5Z,8E,10Z) -heptadecatrienoic acid
12(S)-HHTrE
Formula C17H28O3
Exact Mass 280.203844762
Average Mass 280.40242
SMILES CCCCCC(O)C=CC=CCC=CCCCC(O)=O
Physicochemical Information
12(S)-HHTrE is produced either enzymatically by thromboxane A2 synthase on thromboxane A2 or by a nonenzymatic, heme-mediated decomposition of PGH Diczfalusy_U et al..
12(S)-HHTrE is an excellent substrate for porcine kidney 15-hydroxyprostaglandin dehydrogenase with a K value of 0.8 mu M Liu_Y et al.. Porcine kidney 15-hydroxyprostaglandin dehydrogenase converts 12(S)-HHTrE to 12-OxoHTrE Liu_Y et al..
At a concentration of 0.5 μ M 12(S)-HHTrE stimulates prostacyclin production in human endothelial cells Sadowitz_PD et al..
Spectral Information
Mass Spectra
UV Spectra λ max: 232nm ε : 33,400
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF17307HO01 See above. Diczfalusy_U et al. 1977
n.a. LBF17307HO01 See above. Liu_Y et al. 1985
n.a. LBF17307HO01 See above. Sadowitz_PD et al. 1987