LBF20207PG28: Difference between revisions

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{{Lipid/Header}}
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|LipidBank=XPR1711
|LipidBank=XPR1711
|LipidMaps=LMFA03010148
|LipidMaps=LMFA03010148
|SysName=9-oxo-11alpha,15S-dihydroxy-prosta-5E,13E-dien-1-oic acid
|SysName=9-Oxo- (11alpha,15S) -dihydroxy-prosta- (trans-5,trans-13) -dien-1-oic acid
|Common Name=&&5-trans Prostaglandin E2&&
|Common Name=&&5-trans Prostaglandin E_2&&9-Oxo- (11alpha,15S) -dihydroxy-prosta- (5E,13E) -dien-1-oic acid&&
|Source=5-trans PGE2 is naturally produced by some gorgonian corals and is also a common impurity in commercial lots of PGE1.
|Chemical Synthesis=
|Metabolism=
|Biological Activity=5-trans PGE2 has 18 times potency in activating adenylate cyclase compared to PGE2.[[Reference:Hensby_CN:MacDermot_J:,Biochem. Soc. Trans.,1979,7,1302|{{RelationTable/GetFirstAuthor|Reference:Hensby_CN:MacDermot_J:,Biochem. Soc. Trans.,1979,7,1302}}]] 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated dby tissue-type plasminogen activator.[[Reference:Shimokawa_M:Urano_T:Kinoshita_T:,Biochim. Biophys. Acta,1992,1137,317|{{RelationTable/GetFirstAuthor|Reference:Shimokawa_M:Urano_T:Kinoshita_T:,Biochim. Biophys. Acta,1992,1137,317}}]] And it also inhibits platelet
}}
}}
{{Lipid/Footer}}

Latest revision as of 08:31, 21 October 2010

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Upper classes: LB LBF



5-trans Prostaglandin E2
LBF20207PG28.png
Structural Information
9-Oxo- (11α,15S) -dihydroxy-prosta- (trans-5,trans-13) -dien-1-oic acid
  • 5-trans Prostaglandin E2
  • 9-Oxo- (11α,15S) -dihydroxy-prosta- (5E,13E) -dien-1-oic acid
Formula C20H32O5
Exact Mass 352.224974134
Average Mass 352.46508
SMILES C(CC[C@@H](O)C=C[C@H]([C@H]1CC=CCCCC(O)=O)[C@@H](CC1=O)O)CC
Physicochemical Information
5-trans PGE2 is naturally produced by some gorgonian corals and is also a common impurity in commercial lots of PGE1.
5-trans PGE2 has 18 times potency in activating adenylate cyclase compared to PGE2. Hensby_CN et al. 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated dby tissue-type plasminogen activator. Shimokawa_M et al. And it also inhibits platelet
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20207PG28 See above. Hensby_CN et al. 1979
n.a. LBF20207PG28 See above. Shimokawa_M et al. 1992