LBF20207PG46: Difference between revisions

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|LipidBank=XPR1788
|LipidBank=XPR1788
|LipidMaps=-
|LipidMaps=-
|SysName=9a,11a,15S-trihydroxy- (8b) -prosta-5Z,13E-dien-1-oic acid
|SysName=(9alpha,11alpha,15S) -Trihydroxy- (8beta) -prosta- (cis-5,trans-13) -dien-1-oic acid
|Common Name=&&8-iso Prostaglandin F_2alpha&&9a,11a,15S-trihydroxy- (8b) -prosta-5Z,13E-dien-1-oic acid&&
|Common Name=&&8-iso Prostaglandin F_2 alpha&&(9alpha,11alpha,15S) -Trihydroxy- (8beta) -prosta- (5Z,13E) -dien-1-oic acid&&
|Source=In normal human urine, 8-iso PGF2<FONT FACE="Symbol">a</FONT> level are about 180-200 pg/mg of creatinine.[[Reference:Morrow_JD:Hrris_TM:Roberts_LJ:2nd:,Anal. Biochem.,1990,184,1|{{RelationTable/GetFirstAuthor|Reference:Morrow_JD:Hrris_TM:Roberts_LJ:2nd:,Anal. Biochem.,1990,184,1}}]];>
|Source=In normal human urine, 8-iso PGF2 alpha  level are about 180-200 pg/mg of creatinine.[[Reference:Morrow_JD:Hrris_TM:Roberts_LJ:2nd:,Anal. Biochem.,1990,184,1|{{RelationTable/GetFirstAuthor|Reference:Morrow_JD:Hrris_TM:Roberts_LJ:2nd:,Anal. Biochem.,1990,184,1}}]]
|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=
|Metabolism=
|Biological Activity=8-iso PGF2 alpha  is reported to inhibit platelet aggregation induced by U-46619 (1  mu M) and I-BOP (0.3  mu M) with IC50 of 1.6  mu M and 1.8  mu M, respectively.[[Reference:Morrow_JD:Minton_TA:Roberts_LJ:2nd:,Prostaglandins,1992,44,155|{{RelationTable/GetFirstAuthor|Reference:Morrow_JD:Minton_TA:Roberts_LJ:2nd:,Prostaglandins,1992,44,155}}]]
}}
}}


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{{Lipid/Footer}}

Latest revision as of 08:36, 21 October 2010

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Upper classes: LB LBF



8-iso Prostaglandin F2α
LBF20207PG46.png
Structural Information
(9α,11α,15S) -Trihydroxy- (8β) -prosta- (cis-5,trans-13) -dien-1-oic acid
  • 8-iso Prostaglandin F2α
  • (9α,11α,15S) -Trihydroxy- (8β) -prosta- (5Z,13E) -dien-1-oic acid
Formula C20H34O5
Exact Mass 354.240624198
Average Mass 354.48096000000004
SMILES C(CC[C@H](O)C=C[C@H]([C@@H]1CC=CCCCC(O)=O)[C@@H](C[C@@H]1O)O)CC
Physicochemical Information
In normal human urine, 8-iso PGF2 alpha level are about 180-200 pg/mg of creatinine. Morrow_JD et al.
8-iso PGF2 alpha is reported to inhibit platelet aggregation induced by U-46619 (1 mu M) and I-BOP (0.3 mu M) with IC50 of 1.6 mu M and 1.8 mu M, respectively. Morrow_JD et al.
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20207PG46 See above. Morrow_JD et al. 1990
n.a. LBF20207PG46 See above. Morrow_JD et al. 1992