LBF20207TX01

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Upper classes: LB LBF



Thromboxane A2
LBF20207TX01.png
Structural Information
7- [ 3- (3S-Hydroxy-1-trans -octenyl) - (1S,5S,4,6) -dioxabicyclo [ 3.1.1 ] hept-2-yl ] -5-cis -heptenoic acid
  • Thromboxane A2
  • 7- [ 3- (3 (S) -Hydroxy-1 (E) -octenyl) -1 (S) ,5 (S) ,4,6-dioxabicyclo [ 3.1.1 ] hept-2-yl ] -5 (Z) -heptenoic acid
TXA2
Formula C20H32O5
Exact Mass 352.224974134
Average Mass 352.46508
SMILES C(CC[C@@H](O)C=C[C@H]([C@@H](CC=CCCCC(O)=O)1)O[C@H](C2)O[C@@H]12)CC
Physicochemical Information
Thromboxane A2 is produced in platelets, polymorphonuclear leukocytes, macrophages, lung, kidney and spleen of various animals upon various biological stimulations Moncada_S et al..
Prostaglandin H2 produced by the catalysis of cyclooxygenase is further metabolized to thrombaxne A2 by thromboxane synthaase. Thromboxane A2 is unstable (half life 30 sec) and its oxetane ring is hydrolyzed to hemiacetal thromboxane B2 Needleman_P et al.. The major urinary metabolite of tromboxane B2 is 2,3-dinor-thromboxane B2 Kindahl_H , and 11-dehydro-thromboxane B2 is known as a suitble parameter for monitoring thromboxane production in human Westlund_P et al..
Thromboxane A2 aggregates platelets and constricts blood vessels and bronchi Whittle_BJ et al.. Thromboxane A2 binds to a specific recptor (TP) coupled to Gq protein Ushikubi_F et al..
cDNA and genomic DNA for thromboxane A synthase Tanabe_T et al. and those fro thromboxane A2 receptor Ushikubi_F et al. were cloned.
Stability:unstable in water around neutrality with a half life of about 40 sec at 37°C and decomposes to TXB2 and 12-hydroxy-5,8,10-heptadecatrienoic acid Moncada_S et al..
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20207TX01 See above. Kindahl_H 1977
n.a. LBF20207TX01 See above. Moncada_S et al. 1978
n.a. LBF20207TX01 See above. Needleman_P et al. 1986
n.a. LBF20207TX01 See above. Tanabe_T et al. 1995
n.a. LBF20207TX01 See above. Ushikubi_F et al. 1995
n.a. LBF20207TX01 See above. Westlund_P et al. 1986