LBF20306EO02: Difference between revisions

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|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=
|Metabolism=
|Symbol=(±)8(9)-EpETrE
|Symbol=(+-)8(9)-EpETrE
|Biological Activity=(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction [[Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578|{{RelationTable/GetFirstAuthor|Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578}}]]>.(±)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca^{2+} pools in cultured smooth muscle cells [[Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546|{{RelationTable/GetFirstAuthor|Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546}}]].
|Biological Activity=(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction [[Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578|{{RelationTable/GetFirstAuthor|Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578}}]]>.(±)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca^{2+} pools in cultured smooth muscle cells [[Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546|{{RelationTable/GetFirstAuthor|Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546}}]].
}}
}}


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{{Lipid/Footer}}

Revision as of 01:56, 21 April 2010

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Upper classes: LB LBF



(+-) -8 (9) -epoxy-5Z,11Z,14Z-eicosatrienoic acid
LBF20306EO02.png
Structural Information
dl-8 (9) -epoxy-5Z,11Z,14Z-eicosatrienoic acid
  • (+-) -8 (9) -epoxy-5Z,11Z,14Z-eicosatrienoic acid
(+-)8(9)-EpETrE
Formula C20H32O3
Exact Mass 320.23514489
Average Mass 320.46628
SMILES C(CC=CCC=CCC(O1)C1CC=CCCCC(O)=O)CCC
Physicochemical Information
(±)8(9)-EpETrE is biosynthesized in rat and rabbit liver microsomes by cytochrome P450 Oliw_EH et al. Chacos_N et al.. (±)8(9)-EpETrE is a major P450 metabolite in the renal cortex Zhang_JY et al..
(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction Katoh_T et al.>.(±)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca^{2+} pools in cultured smooth muscle cells Graber_MN et al..
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20306EO02 See above. Chacos_N et al. 1982
n.a. LBF20306EO02 See above. Graber_MN et al. 1997
n.a. LBF20306EO02 See above. Katoh_T et al. 1991
n.a. LBF20306EO02 See above. Oliw_EH et al. 1982
n.a. LBF20306EO02 See above. Zhang_JY et al. 1992