LBF20306PG01: Difference between revisions

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|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=15-deoxy-<FONT FACE="Symbol">D</FONT><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>2</FONT></SUP><SUP><FONT SIZE=-1>.</FONT></SUP><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>4</FONT></SUP>-Prostaglandin D2 is formed from Prostaglandin D2 via <FONT FACE="Symbol">D</FONT><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>2</FONT></SUP>-Prostaglandin D2. This reaction is proceeded under co-culture with Prostaglandin D2 and serum.[[Reference:Soderstrom_M:Wigren_J:Surapureddi_S:Glass_CK:Hammarstrom_S:,Biochim. Biophys. Acta,2003,1631,35|{{RelationTable/GetFirstAuthor|Reference:Soderstrom_M:Wigren_J:Surapureddi_S:Glass_CK:Hammarstrom_S:,Biochim. Biophys. Acta,2003,1631,35}}]]
|Metabolism=15-deoxy-<FONT FACE="Symbol">D</FONT><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>2</FONT></SUP><SUP><FONT SIZE=-1>.</FONT></SUP><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>4</FONT></SUP>-Prostaglandin D2 is formed from Prostaglandin D2 via <FONT FACE="Symbol">D</FONT><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>2</FONT></SUP>-Prostaglandin D2. This reaction is proceeded under co-culture with Prostaglandin D2 and serum.[[Reference:Soderstrom_M:Wigren_J:Surapureddi_S:Glass_CK:Hammarstrom_S:,Biochim. Biophys. Acta,2003,1631,35|{{RelationTable/GetFirstAuthor|Reference:Soderstrom_M:Wigren_J:Surapureddi_S:Glass_CK:Hammarstrom_S:,Biochim. Biophys. Acta,2003,1631,35}}]]
|Biological Activity= 15-deoxy-<FONT FACE="Symbol">D</FONT><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>2</FONT></SUP><SUP><FONT SIZE=-1>.</FONT></SUP><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>4</FONT></SUP>-Prostaglandin D2 shows cytotoxity on murine leukemia cell line (IC50 value of 0.3 <FONT FACE="Symbol">m</FONT>g/ml).[[Reference:Corey_EJ:Cyr_CR:,Tetrah. Lett.,1974,,1761|{{RelationTable/GetFirstAuthor|Reference:Corey_EJ:Cyr_CR:,Tetrah. Lett.,1974,,1761}}]] 15-deoxy-<FONT FACE="Symbol">D</FONT><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>2</FONT></SUP><SUP><FONT SIZE=-1>.</FONT></SUP><SUP><FONT SIZE=-1>1</FONT></SUP><SUP><FONT SIZE=-1>4</FONT></SUP>-Prostaglandin D2 is a potent activator of eosinophils, inducing calcium mobilization, actin polymerization, and CD11b expression.[[Reference:Monneret_G:Li_H:Vasilescu_J:Rokach_J:Powell_WS:,J. Immunol.,2002,168,3563|{{RelationTable/GetFirstAuthor|Reference:Monneret_G:Li_H:Vasilescu_J:Rokach_J:Powell_WS:,J. Immunol.,2002,168,3563}}]]
}}
}}


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Revision as of 21:00, 6 January 2010

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Upper classes: LB LBF



15-deoxy-Δ12.14-Prostaglandin D2
LBF20306PG01.png
Structural Information
9α-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid
  • 15-deoxy-Δ12.14-Prostaglandin D2
  • 9α-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid
Formula C20H30O4
Exact Mass 334.21440944799997
Average Mass 334.4498
SMILES C([C@H]1CC=CCCCC(O)=O)(C(C[C@@H]1O)=O)=CC=CCCCCC
Physicochemical Information
15-deoxy-D12.14-Prostaglandin D2 is formed from Prostaglandin D2 via D12-Prostaglandin D2. This reaction is proceeded under co-culture with Prostaglandin D2 and serum. Soderstrom_M et al.
15-deoxy-D12.14-Prostaglandin D2 shows cytotoxity on murine leukemia cell line (IC50 value of 0.3 mg/ml). Corey_EJ et al. 15-deoxy-D12.14-Prostaglandin D2 is a potent activator of eosinophils, inducing calcium mobilization, actin polymerization, and CD11b expression. Monneret_G et al.
Spectral Information
Mass Spectra
UV Spectra lmax=296nm e296=18300
IR Spectra
NMR Spectra
Other Spectra
Chromatograms PGD2 and other metabolites are separated with HPLC. Please reffer following paper. SoderstromMet al.
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20306PG01 See above. Corey_EJ et al. 1974
n.a. LBF20306PG01 See above. Monneret_G et al. 2002
n.a. LBF20306PG01 See above. Soderstrom_M et al. 2003