LBF20308PG01: Difference between revisions

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|LipidBank=XPR1726
|LipidBank=XPR1726
|LipidMaps=LMFA03010020
|LipidMaps=LMFA03010020
|SysName=11-oxo-15S-hydroxy-prosta-5Z,9,12E-trien-1-oic acid
|SysName=(cis-5,trans-12)-11-Oxo-15S-hydroxy-prosta-5,9,12-trien-1-oic acid
|Common Name=&&Delta^{12}-Prostaglandin J_2&&11-oxo-15S-hydroxy-prosta-5Z,9,12E-trien-1-oic acid&&
|Common Name=&&Delta^{12}- Prostaglandin J_2&&(5Z,12E)-11-Oxo-15S-hydroxy-prosta-5,9,12-trien-1-oic acid&&
|Source= Delta ^1 ^2 -PGJ2 is a decomposition product of PGD2 in the presence of albumin.[[Reference:Fitzpatrick_FA:Wynalda_MA:,J. Biol. Chem.,1983,258,11713|{{RelationTable/GetFirstAuthor|Reference:Fitzpatrick_FA:Wynalda_MA:,J. Biol. Chem.,1983,258,11713}}]]
|Source= Delta ^{12}-PGJ2 is a decomposition product of PGD2 in the presence of albumin.[[Reference:Fitzpatrick_FA:Wynalda_MA:,J. Biol. Chem.,1983,258,11713|{{RelationTable/GetFirstAuthor|Reference:Fitzpatrick_FA:Wynalda_MA:,J. Biol. Chem.,1983,258,11713}}]]
|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=
|Metabolism=
|Biological Activity= Delta ^1 ^2 -PGJ2 has antitumor and antibiral activity, inhibiting growth of cultured L1210 cells with an IC50 of 0.7  mu g/ml.[[Reference:Kato_T:Fukushima_M:Kurozumi_S:Noyori_R:,Cancer Res.,1986,46,3538|{{RelationTable/GetFirstAuthor|Reference:Kato_T:Fukushima_M:Kurozumi_S:Noyori_R:,Cancer Res.,1986,46,3538}}]]
|Biological Activity= Delta ^{12}-PGJ2 has antitumor and antibiral activity, inhibiting growth of cultured L1210 cells with an IC50 of 0.7  mu g/ml.[[Reference:Kato_T:Fukushima_M:Kurozumi_S:Noyori_R:,Cancer Res.,1986,46,3538|{{RelationTable/GetFirstAuthor|Reference:Kato_T:Fukushima_M:Kurozumi_S:Noyori_R:,Cancer Res.,1986,46,3538}}]]
}}
}}


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{{Lipid/Footer}}

Latest revision as of 09:03, 21 October 2010

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Upper classes: LB LBF



Δ12- Prostaglandin J2
LBF20308PG01.png
Structural Information
(cis-5,trans-12)-11-Oxo-15S-hydroxy-prosta-5,9,12-trien-1-oic acid
  • Δ12- Prostaglandin J2
  • (5Z,12E)-11-Oxo-15S-hydroxy-prosta-5,9,12-trien-1-oic acid
Formula C20H30O4
Exact Mass 334.21440944799997
Average Mass 334.4498
SMILES C(CC[C@@H](O)CC=C(C(=O)1)[C@@H](CC=CCCCC(O)=O)C=C1)CC
Physicochemical Information
Delta ^{12}-PGJ2 is a decomposition product of PGD2 in the presence of albumin. Fitzpatrick_FA et al.
Delta ^{12}-PGJ2 has antitumor and antibiral activity, inhibiting growth of cultured L1210 cells with an IC50 of 0.7 mu g/ml. Kato_T et al.
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20308PG01 See above. Fitzpatrick_FA et al. 1983
n.a. LBF20308PG01 See above. Kato_T et al. 1986