LBF20406HO07: Difference between revisions
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{{Metabolite | {{Metabolite | ||
|LipidBank=DFA8102 | |LipidBank=DFA8102 | ||
|LipidMaps= | |LipidMaps=LMFA03060017 | ||
|SysName=5S,6R- | |SysName=(5S,6R) -Dihydroxy- (trans-7,trans-9,cis-11,cis-14) -eicosatetraenoic acid | ||
|Common Name=&&5S,6R- | |Common Name=&&(5S,6R) -Dihydroxy- (7E,9E,11Z,14Z) -eicosatetraenoic acid&& | ||
|Solubility=Soluble in ethanol. | |Solubility=Soluble in ethanol. | ||
|UV Spectra= | |UV Spectra= lambda max:273nm epsilon :40,000 | ||
|Source=5S,6R-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A 4 . | |Source=5S,6R-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A 4 . | ||
|Chemical Synthesis= | |Chemical Synthesis= | ||
|Metabolism=Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE[[Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469|{{RelationTable/GetFirstAuthor|Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469}}]]; | |Metabolism=Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE[[Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469|{{RelationTable/GetFirstAuthor|Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469}}]]. | ||
|Symbol=5(S),6(R)-DiHETE | |||
|Biological Activity=5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes[[Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635|{{RelationTable/GetFirstAuthor|Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635}}]]. It induces guinea pig ileum contraction with an ED value of 1.3 μ M. | |||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} | ||
Latest revision as of 07:24, 21 October 2010
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | DFA8102 |
| LipidMaps | LMFA03060017 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406HO07 |
| (5S,6R) -Dihydroxy- (7E,9E,11Z,14Z) -eicosatetraenoic acid | |
|---|---|
| |
| Structural Information | |
| (5S,6R) -Dihydroxy- (trans-7,trans-9,cis-11,cis-14) -eicosatetraenoic acid | |
| |
| 5(S),6(R)-DiHETE | |
| Formula | C20H32O4 |
| Exact Mass | 336.23005951199997 |
| Average Mass | 336.46567999999996 |
| SMILES | C(CC=CCC=CC=CC=C[C@@H](O)[C@@H](O)CCCC(O)=O)CCC |
| Physicochemical Information | |
| Soluble in ethanol. | |
| 5S,6R-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A 4 . | |
| Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE Haeggstrom_J et al.. | |
| 5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes Muller_A et al.. It induces guinea pig ileum contraction with an ED value of 1.3 μ M. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | λ max:273nm ε :40,000 |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | |
| Reported Metabolites, References | |||||||||||||||
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