LBF20406HO07: Difference between revisions

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|LipidBank=DFA8102
|LipidBank=DFA8102
|LipidMaps=LMFA03060017
|LipidMaps=LMFA03060017
|SysName=5S,6R-dihydroxy-7E,9E,11Z,14Z-eicosatetraenoic acid
|SysName=(5S,6R) -Dihydroxy- (trans-7,trans-9,cis-11,cis-14) -eicosatetraenoic acid
|Common Name=&&5S,6R-dihydroxy-7E,9E,11Z,14Z-eicosatetraenoic acid&&
|Common Name=&&(5S,6R) -Dihydroxy- (7E,9E,11Z,14Z) -eicosatetraenoic acid&&
|Solubility=Soluble in ethanol.
|Solubility=Soluble in ethanol.
|UV Spectra= lambda max:273nm  epsilon :40,000
|UV Spectra= lambda max:273nm  epsilon :40,000
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|Metabolism=Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE[[Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469|{{RelationTable/GetFirstAuthor|Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469}}]].
|Metabolism=Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE[[Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469|{{RelationTable/GetFirstAuthor|Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469}}]].
|Symbol=5(S),6(R)-DiHETE
|Symbol=5(S),6(R)-DiHETE
|Biological Activity=5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes[[Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635|{{RelationTable/GetFirstAuthor|Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635}}]]. It induces guinea pig ileum contraction with an ED value of 1.3 mu M.
|Biological Activity=5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes[[Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635|{{RelationTable/GetFirstAuthor|Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635}}]]. It induces guinea pig ileum contraction with an ED value of 1.3 μ M.
}}
}}


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Latest revision as of 07:24, 21 October 2010

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Upper classes: LB LBF



(5S,6R) -Dihydroxy- (7E,9E,11Z,14Z) -eicosatetraenoic acid
LBF20406HO07.png
Structural Information
(5S,6R) -Dihydroxy- (trans-7,trans-9,cis-11,cis-14) -eicosatetraenoic acid
  • (5S,6R) -Dihydroxy- (7E,9E,11Z,14Z) -eicosatetraenoic acid
5(S),6(R)-DiHETE
Formula C20H32O4
Exact Mass 336.23005951199997
Average Mass 336.46567999999996
SMILES C(CC=CCC=CC=CC=C[C@@H](O)[C@@H](O)CCCC(O)=O)CCC
Physicochemical Information
Soluble in ethanol.
5S,6R-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A 4 .
Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE Haeggstrom_J et al..
5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes Muller_A et al.. It induces guinea pig ileum contraction with an ED value of 1.3 μ M.
Spectral Information
Mass Spectra
UV Spectra λ max:273nm ε :40,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406HO07 See above. Haeggstrom_J et al. 1988
n.a. LBF20406HO07 See above. Muller_A et al. 1989