LBF20406HO12: Difference between revisions

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{{Metabolite
{{Metabolite
|LipidBank=DFA8130
|LipidBank=DFA8130
|LipidMaps=-
|LipidMaps=LMFA03060021
|SysName=8R-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid
|SysName=8R-Hydroxy- (cis-5,trans-9,cis-11,cis-14) -eicosatetraenoic acid
|Common Name=&&8R-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid&&
|Common Name=&&8R-Hydroxy- (5Z,9E,11Z,14Z) -eicosatetraenoic acid&&
|UV Spectra=<FONT FACE="Symbol">l</FONT>max: 237nm <FONT FACE="Symbol">e</FONT>: 27,000
|UV Spectra= lambda max: 237nm epsilon : 27,000
|Source=8(R)-HETE is a metabolite of arachidonic acid by the 8-lipoxygenase pathway in marine organisms [[Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040|{{RelationTable/GetFirstAuthor|Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040}}]][[Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829|{{RelationTable/GetFirstAuthor|Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829}}]];>.
|Source=8(R)-HETE is a metabolite of arachidonic acid by the 8-lipoxygenase pathway in marine organisms [[Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040|{{RelationTable/GetFirstAuthor|Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040}}]][[Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829|{{RelationTable/GetFirstAuthor|Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829}}]].
|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=The precursor of 8(R)-HETE, 8(R)-HpETE, is the putative intermediate in the biosynthesis of marine prostaglandins via the allene oxide synthase pathway.[[Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829|{{RelationTable/GetFirstAuthor|Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829}}]];>.
|Metabolism=The precursor of 8(R)-HETE, 8(R)-HpETE, is the putative intermediate in the biosynthesis of marine prostaglandins via the allene oxide synthase pathway.[[Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829|{{RelationTable/GetFirstAuthor|Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829}}]].
|Symbol=8(R)-HETE
|Biological Activity=8(R)-HETE induces maturation of starfish oocytes at a concentration of 0.071 &mu; M [[Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040|{{RelationTable/GetFirstAuthor|Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040}}]]. This activity if neglible in the 8(S)-enantiomer [[Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040|{{RelationTable/GetFirstAuthor|Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040}}]].
}}
}}


{{Lipid/Footer}}
{{Lipid/Footer}}

Latest revision as of 07:26, 21 October 2010

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Upper classes: LB LBF



8R-Hydroxy- (5Z,9E,11Z,14Z) -eicosatetraenoic acid
LBF20406HO12.png
Structural Information
8R-Hydroxy- (cis-5,trans-9,cis-11,cis-14) -eicosatetraenoic acid
  • 8R-Hydroxy- (5Z,9E,11Z,14Z) -eicosatetraenoic acid
8(R)-HETE
Formula C20H32O3
Exact Mass 320.23514489
Average Mass 320.46628
SMILES C(CC=CCC=CC=C[C@@H](CC=CCCCC(O)=O)O)CCC
Physicochemical Information
8(R)-HETE is a metabolite of arachidonic acid by the 8-lipoxygenase pathway in marine organisms Meijer_L et al. Brash_AR et al..
The precursor of 8(R)-HETE, 8(R)-HpETE, is the putative intermediate in the biosynthesis of marine prostaglandins via the allene oxide synthase pathway. Brash_AR et al..
8(R)-HETE induces maturation of starfish oocytes at a concentration of 0.071 μ M Meijer_L et al.. This activity if neglible in the 8(S)-enantiomer Meijer_L et al..
Spectral Information
Mass Spectra
UV Spectra λ max: 237nm ε : 27,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406HO12 See above. Brash_AR et al. 1987
n.a. LBF20406HO12 See above. Meijer_L et al. 1986