LBF20406HO13

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Upper classes: LB LBF



8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid
LBF20406HO13.png
Structural Information
8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid
  • 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid
8(S)-HETE
Formula C20H32O3
Exact Mass 320.23514489
Average Mass 320.46628
SMILES C(CC=CCC=CC=C[C@H](CC=CCCCC(O)=O)O)CCC
Physicochemical Information
8(S)-HETE is a major lipoxygenase product in PMA-treated mouse epidermis Hughes_MA et al..
8(S)-HETE is synthesized from arachidonic acid by a 8(S)-lipoxygenase present in phorbol ester-treated mouse skin Hughes_MA et al..
Both 8(S)- and 8(R)-HETEs activate mouse skin protein kinase C at a dose of 100 mu M Hughes_MA et al.. It activates mouse keratinocyte protein kinase C with an IC_5 _0 of 100 mu M Lo_HH et al.. 8(S)-HETE also activates PPAR alpha selectively at concentrations as low as 0.3 mu M Yu_K et al..
Spectral Information
Mass Spectra
UV Spectra λ max: 237nm ε : 27,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406HO13 See above. Hughes_MA et al. 1991
n.a. LBF20406HO13 See above. Lo_HH et al. 1994
n.a. LBF20406HO13 See above. Yu_K et al. 1995