LBF20406LT02

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Upper classes: LB LBF



LEUKOTRIENE B4
LBF20406LT02.png
Structural Information
5 (S) ,12 (R) -Dihydroxyeicosa-6 (Z) ,8 (E) ,10 (E) ,14 (Z) -tetraenoic acid
  • LEUKOTRIENE B4
  • 5 (S) ,12 (R) -Dihydroxyeicosa-6 (Z) ,8 (E) ,10 (E) ,14 (Z) -tetraenoic acid
LTB4
Formula C20H32O4
Exact Mass 336.23005951199997
Average Mass 336.46567999999996
SMILES C(CC=CC[C@H](C=CC=CC=C[C@H](CCCC(O)=O)O)O)CCC
Physicochemical Information
METHANOL Corey_EJ et al.
Leukotriene B4 is produced by polymorphonuclear leukocytes and macrophages of various animal species upon various stimulations on the cells Samuelsson_B et al. Hammarstrom_S .
Corey_EJ et al.
LBF20406LT02FT0001.gif
Arachidonic acid is metabolized to leukotrienen A4 with 5,6-epoxide by 5-lipoxygenases, and the product is further transformed to leukotrienee B4 by leukotriene A hydrolase Ford-Hutchinson_AW et al.. Leukotriene B4 is metabolized to lose its bioactivities either by omega -oxidation Hammarstrom_S or by leukotriene B4 12-hydroxydehydrogenase Yokomizo_T et al..
Leukotriene B4 causes adhesion of leukocytes to endothelial cells, stimulates chemotaxis and chemokinesis of leukocytes Hammarstrom_S , and enhances superoxide anion production by human polymorphonuclear leukocytes Sumimoto_H et al.. Leukotriene B4 binds to a specific receptor with 7 transmembrane domains coupled to Gi/Go or Gq protein Yokomizo_T et al..
cDNA and genomic DNA of 5-lipoxygenase Funk_CD and cDNA for Leukotriene A hydrolase Funk_CD were cloned. cDNA for leukotriene B 12-hydroxydehydrogenase was cloned Yokomizo_T et al..
Spectral Information
Mass Spectra m/e 336, 319, 301 Yergey_JA et al.
UV Spectra METHANOL : 260( ε 38,000), 270.5( ε 50,000), 281( ε 39,000)nm Corey_EJ et al.
IR Spectra
NMR Spectra 1H-NMR(250MHz, D2O) : δ 6.45(m, 1H, 8-CH), 6.15(m, 2H, 9,10-CH), 6.0(m, 1H, 7-CH), 5.65(m, 1H, 11-CH), 5.40(m, 1H, 15-CH), 5.25(m, 2H, 6,14-CH), 4.60(5-CH), 4.05(m, 1H, 12-CH), 2.15(m, 2H, 13-CH), 2.00(m, 1H, 2-CH), 1.85(m, 2H, 16-CH), 1.35-1.60(m, 4H, 3,4-CH), 1.00-1.25(m, 6H, 17,18,19-CH), 0.70(m, 3H, 20-CH) Merrer_YL et al.
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406LT02 See above. Corey_EJ et al. 1980
n.a. LBF20406LT02 See above. Ford-Hutchinson_AW et al. 1994
n.a. LBF20406LT02 See above. Funk_CD 1993
n.a. LBF20406LT02 See above. Hammarstrom_S 1983
n.a. LBF20406LT02 See above. Merrer_YL et al. 1989
n.a. LBF20406LT02 See above. Samuelsson_B et al. 1982
n.a. LBF20406LT02 See above. Sumimoto_H et al. 1984
n.a. LBF20406LT02 See above. Yergey_JA et al. 1986
n.a. LBF20406LT02 See above. Yokomizo_T et al. 1997
n.a. LBF20406LT02 See above. Yokomizo_T et al. 1993
n.a. LBF20406LT02 See above. Yokomizo_T et al. 1996