LBF20406LT04: Difference between revisions

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{{Lipid/Header}}
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|LipidBank=XPR3113
|LipidBank=XPR3113
|LipidMaps=LMFA03020011
|LipidMaps=LMFA03020011
|SysName=N,N-dimethy-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide
|SysName=N,N-Dimethyl- (5S,12R) -dihydroxy- (cis-6,trans-8,trans-10,cis-14) -eicosatetraenamide
|Common Name=&&LeukotrieneB4 dimethyl amide&&
|Common Name=&&Leukotriene B_4 dimethylamide&&N,N-Dimethyl- (5S,12R) -dihydroxy- (6Z,8E,10E,14Z) -eicosatetraenamide&&
|Source=
|Chemical Synthesis=
|Metabolism=
|Biological Activity=Leukotriene B4 dimethylamide inhibits LTB4 induced degranulation of human neutrophils at the concentration of 130 nM (Ki) and release of lysozyme of PMNL.[[Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565|{{RelationTable/GetFirstAuthor|Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565}}]][[Reference:Shimazaki_T:Kobayashi_Y:Sato_F:Iwama_T:Shikada_K:,Prostaglandins,1990,39,459|{{RelationTable/GetFirstAuthor|Reference:Shimazaki_T:Kobayashi_Y:Sato_F:Iwama_T:Shikada_K:,Prostaglandins,1990,39,459}}]][[Reference:Showell_HJ:Otterness_IG:Marfat_A:Corey_EJ:,Biochem. Biophys. Res. Commun.,1982,106,741|{{RelationTable/GetFirstAuthor|Reference:Showell_HJ:Otterness_IG:Marfat_A:Corey_EJ:,Biochem. Biophys. Res. Commun.,1982,106,741}}]] The effect may be due to the antagonistic effect against LTB4 receptor.[[Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565|{{RelationTable/GetFirstAuthor|Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565}}]]
}}
}}
{{Lipid/Footer}}

Latest revision as of 06:23, 9 November 2010

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Upper classes: LB LBF



Leukotriene B4dimethylamide
LBF20406LT04.png
Structural Information
N,N-Dimethyl- (5S,12R) -dihydroxy- (cis-6,trans-8,trans-10,cis-14) -eicosatetraenamide
  • Leukotriene B4dimethylamide
  • N,N-Dimethyl- (5S,12R) -dihydroxy- (6Z,8E,10E,14Z) -eicosatetraenamide
Formula C22H37NO3
Exact Mass 363.27734405499996
Average Mass 363.53412000000003
SMILES C(=CC[C@@H](O)C=CC=CC=C[C@H](CCCC(N(C)C)=O)O)CCCCC
Physicochemical Information
Leukotriene B4 dimethylamide inhibits LTB4 induced degranulation of human neutrophils at the concentration of 130 nM (Ki) and release of lysozyme of PMNL. Falcone_RC et al. Shimazaki_T et al. Showell_HJ et al. The effect may be due to the antagonistic effect against LTB4 receptor. Falcone_RC et al.
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406LT04 See above. Falcone_RC et al. 1990
n.a. LBF20406LT04 See above. Shimazaki_T et al. 1990
n.a. LBF20406LT04 See above. Showell_HJ et al. 1982