LBF20407LX01: Difference between revisions

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|LipidBank=DFA8153
|LipidBank=DFA8153
|LipidMaps=LMFA03040001
|LipidMaps=LMFA03040001
|SysName=5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
|SysName=&&(5S,6R,15S) -Trihydroxy- (7-trans,9-trans,11-cis,13-trans) -
|Common Name=&&Lipoxin A_4&&
icosatetraenoic acid
|Common Name=&&Lipoxin A_4&&(5S,6R,15S) -Trihydroxy- (7E,9E,11Z,13E) -eicosatetraenoic acid&&
|UV Spectra= lambda max: 302nm  epsilon : 50,000
|UV Spectra= lambda max: 302nm  epsilon : 50,000
|Source=LXA4 is formed in vitro by a number of mechanisms from arachidonic acid, 15-HpETE, and leukotriene A4 (LTA4 ) [[Reference:Edenius_C:Stenke_L:Lindgren_JA:,Eur. J. Biochem.,1991,199,401|{{RelationTable/GetFirstAuthor|Reference:Edenius_C:Stenke_L:Lindgren_JA:,Eur. J. Biochem.,1991,199,401}}]][[Reference:Serhan_CN:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1984,81,5335|{{RelationTable/GetFirstAuthor|Reference:Serhan_CN:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1984,81,5335}}]].
|Source=LXA4 is formed in vitro by a number of mechanisms from arachidonic acid, 15-HpETE, and leukotriene A4 (LTA4 ) [[Reference:Edenius_C:Stenke_L:Lindgren_JA:,Eur. J. Biochem.,1991,199,401|{{RelationTable/GetFirstAuthor|Reference:Edenius_C:Stenke_L:Lindgren_JA:,Eur. J. Biochem.,1991,199,401}}]][[Reference:Serhan_CN:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1984,81,5335|{{RelationTable/GetFirstAuthor|Reference:Serhan_CN:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1984,81,5335}}]].

Revision as of 02:18, 2 June 2010

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Upper classes: LB LBF



Lipoxin A4
LBF20407LX01.png
Structural Information
&&(5S,6R,15S) -Trihydroxy- (7-trans,9-trans,11-cis,13-trans) -

icosatetraenoic acid

  • Lipoxin A4
  • (5S,6R,15S) -Trihydroxy- (7E,9E,11Z,13E) -eicosatetraenoic acid
LXA4
Formula C20H32O5
Exact Mass 352.224974134
Average Mass 352.46508
SMILES C(CCC(C=CC=CC=CC=CC(O)C(O)CCCC(O)=O)O)CC
Physicochemical Information
LXA4 is formed in vitro by a number of mechanisms from arachidonic acid, 15-HpETE, and leukotriene A4 (LTA4 ) Edenius_C et al. Serhan_CN et al..
LXA is equipotent to LTB in inducing superoxide generation in human neutrophils (0.1 mu M) Serhan_CN et al.. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis promotion, natural killer cell inhibition, and monocyte migration and adhesion Serhan_CN et al. Ramstedt_U et al. Maddox_JF et al..
Spectral Information
Mass Spectra
UV Spectra λ max: 302nm ε : 50,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20407LX01 See above. Adams_J et al. 1985
n.a. LBF20407LX01 See above. Brady_HR et al. 1996
n.a. LBF20407LX01 See above. Edenius_C et al. 1991
n.a. LBF20407LX01 See above. Fiore_S et al. 1994
n.a. LBF20407LX01 See above. Maddox_JF et al. 1996
n.a. LBF20407LX01 See above. Ramstedt_U et al. 1987
n.a. LBF20407LX01 See above. Serhan_CN 1994
n.a. LBF20407LX01 See above. Serhan_CN et al. 1984
n.a. LBF20407LX01 See above. Serhan_CN et al. 1984
n.a. LBF20407LX01 See above. Serhan_CN et al. 1986