LBF232nnPG03: Difference between revisions

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|LipidBank=XPR1794
|LipidBank=XPR1794
|LipidMaps=LMFA03010123
|LipidMaps=LMFA03010123
|SysName=9a,11a,15S-trihydroxy-17-phenyl-18,19,20-trinor-5Z,13E-dien-1-amide
|SysName=(9alpha,11alpha,15S) -Trihydroxy-17-phenyl-18,19,20-trinor-prosta- (cis-5,trans-13) -dien-1-amide
|Common Name=&&17-phenyl trinor Prostaglandin F_2alpha amide&&9a,11a,15S-trihydroxy-17-phenyl-18,19,20-trinor-5Z,13E-dien-1-amide&&
|Common Name=&&17-phenyl trinor Prostaglandin F_2 alpha amide&&(9alpha,11alpha,15S) -Trihydroxy-17-phenyl-18,19,20-trinor-prosta- (5Z,13E) -dien-1-amide&&
|Source=
|Chemical Synthesis=
|Metabolism=
|Biological Activity=17-phenyl trinor PGF2 alpha  amide is expected to show the typical intraocular effects of latanoprost. In vivo study revlealed that 17-phenyl trinor PGF2 alpha  amide was converted the amides of various PGs to the free acids.[[Reference:Woodward_DF:Krauss_AH:Chen_J:Lai_RK:Spada_CS:Burk_RM:Andrews_SW:Shi_L:Liang_Y:Kedzie_KM_et_al:,Surv. Ophthalmol.,2001,45 Suppl 4,S337|{{RelationTable/GetFirstAuthor|Reference:Woodward_DF:Krauss_AH:Chen_J:Lai_RK:Spada_CS:Burk_RM:Andrews_SW:Shi_L:Liang_Y:Kedzie_KM_et_al:,Surv. Ophthalmol.,2001,45 Suppl 4,S337}}]]
}}
}}


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Latest revision as of 09:06, 21 October 2010

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Upper classes: LB LBF



17-phenyl trinor Prostaglandin F2α amide
LBF232nnPG03.png
Structural Information
(9α,11α,15S) -Trihydroxy-17-phenyl-18,19,20-trinor-prosta- (cis-5,trans-13) -dien-1-amide
  • 17-phenyl trinor Prostaglandin F2α amide
  • (9α,11α,15S) -Trihydroxy-17-phenyl-18,19,20-trinor-prosta- (5Z,13E) -dien-1-amide
Formula C23H33NO4
Exact Mass 387.24095854899997
Average Mass 387.51246
SMILES C(c(c2)cccc2)C[C@@H](C=C[C@H]([C@H]1CC=CCCCC(N)=O)[C@@H](C[C@H](O)1)O)O
Physicochemical Information
17-phenyl trinor PGF2 alpha amide is expected to show the typical intraocular effects of latanoprost. In vivo study revlealed that 17-phenyl trinor PGF2 alpha amide was converted the amides of various PGs to the free acids. Woodward_DF et al.
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF232nnPG03 See above. Woodward_DF et al. 2001