PathwayMap:CeramideBiosynthesis

[title] <2.5,2.5> #Ceramide Biosynthesis //titles [ER] <6.83,66.82>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Endoplasmic reticulum [Cytosol] <70,1>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Cytosol [PlasmaMembraneName] <91.51,4.97>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Plasma Membrane [LysosomeName] <82.14,16.54>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) Lysosome [cisGLD] <24.68,41.48>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) cis/medial Golgi [transGLD] <44.10,41.48>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) trans Golgi [TGNName] <71.40,41.48>css(font-size:20px;background:rgb(200,200,150;border:5px solid black;z-index:2) trans Golgi network //========================================Organelle boxes======================== [ER1] <3.89,0.66,166.03,1024.31>css(background:rgb(200,255,10;border-right:50px solid rgb(200,200,0;box-shadow:none;z-index:1) [ER2] <11.03,52.92,1280.14,340.00>css(background:rgb(200,255,10;border-top:50px solid rgb(200,200,0;box-shadow:none;z-index:1) [ER3] <3.84,53.16,165.38,333.00>css(background:rgb(200,255,10;box-shadow:none;z-index:1) [PlasmaMembrane] <94.81,1.10,51.19,1154.37>css(background:rgb(100,100,100;box-shadow:none;z-index:1;) //Golgi [Golgi] <24.81,20.95,162.20,324.15>css(background:rgb(50,140,140;border:30px solid rgb(100,200,200;box-shadow:none;z-index:1) //Golgi [Golgi_trans] <35.84,20.95,404.71,324.15>css(background:rgb(50,140,140;border:30px solid rgb(100,200,200;box-shadow:none;z-index:1) //Trans Golgi network [TGN] <63.40,20.95,404.71,324.15>css(background:rgb(50,140,140;border:30px solid rgb(100,200,200;box-shadow:none;z-index:1) //Lysosome [Lysosome] (mark) <77.73,0.56,170.61,255.93>css(background:rgb(130,140,140;border:30px solid rgb(130,180,180;box-shadow:none;z-index:1) //=========================================Metabolites===================================================== //Palmitoyl-CoA [PalCoA] <12.68,1.66> PalCoA d=(l_w3)=>u[3KDS] //3-ketodihydrosphingosine [3KDS] <12.68,7.17> 3-KDS d=(l_w3)=>u[DHS] //dihydrosphingosine [DHS] <13.23,12.68> DHS d=(l_w3)=>u[DHC] //dihydroceramide [DHC] <13.23,17.64> DHC d=(l_w3)=>u[Cer] //Ceramide [C1P] <66.71,15.44> !SP{O-PO3} C1P r=(l_w)=>[PlasmaMembrane] //Ceramide [Cer] <12.13,23.15> !SP{O} Cer r=(l_w3)=>u[GlcCer] r=(l_w3)=l[CERT] //Ceramide [Cer2] <38.33,25.73> Cer u=(l_w3)=>u[SM] //Ceramide [Cer3] <56.18,18.90> Cer //Ceramide [Cer4] <63.95,18.19> Cer d=(l_w3)=>d[C1P] //Ceramide [Cer5] <13.79,45.76> Cer //Ceramide [Cer6] <52.92,51.82> Cer //Ceramide [Cer7] <97.02,19.30> Cer u=(l_w3)=>d[SM4] //Ceramide [Cer8] <80.48,4.97> Cer //Ceramide [Cer9] <79.94,11.03> Cer //Sphingosine [Sph] <13.23,32.53> Sph u=(l_w3)=>d[Cer] //Glucosylceramide [GlcCer] <19.30,29.77> !SP{O-Glc} GlcCer d=(l_w3)=>[GlcCer2] d=(l_w3)=l[FAPP2] d=(l_w3)=>u[Cer5] //Glucosylceramide [GlcCer2] <28.12,35.84> GlcCer r=(l_w3)=>l[GlcCer3] //Glucosylceramide [GlcCer3] <38.33,35.18> GlcCer d=(l_w3)=>l[LacCer] //Glucosylceramide [GlcCer4] <66.71,38.04> GlcCer l=(l_w3)=>L[LacCer2] //Glucosylceramide [GlcCer5] <83.79,11.03> GlcCer d=(l_w3)=>d[Cer9] //Lactosylceramide [LacCer] <46.5,36> !SP{O-Glc-Gal} LacCer r=(l_w3)=>r[GM3] //Lactosylceramide [LacCer2] <67,32.5> !SP{O-Glc-Gal} LacCer l=(l_w3)=>L[GB3] d=(l_w3)=>d[GA2] //Globotriaosylceramide [GB3] <66.5,27.5> !SP{O-Glc-Gal-Gal} Gb3 r=(l_w)=>[PlasmaMembrane] //Globoside [GA2] <76.07,34.73> !SP{O-Glc-Gal-GalNAc} GA2 r=(l_w)=>[PlasmaMembrane] //asialoGM１ [GM3] <45.15,30.45> !SP{O-Glc-Gal|           SA} GM3 //asialoGM 3 [GM2] <71.5,22.5> !SP{O-Glc-Gal-GalNAc|           SA|} GM2 r=(l_w)=>[PlasmaMembrane] //GM1 [SM] <43.05,25.20> !SP{O-Choline} SM r=(l_w3)=>d[Cer3] //Sphingomyelin [SM2] <64.50,51.82> SM l=(l_w3)=>r[Cer6] //Sphingomyelin [SM3] <100.33,26.46> SM u=(l_w3)=>d[Cer7] //Sphingomyelin [SM4] <96.47,12.13> SM //Sphingomyelin [SM5] <84.35,4.97> SM u=(l_w3)=>u[Cer8] //===============================================gene======================================== //serine palmitoyl transferase [SPT] <13.23,3.86>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) SPT //3-ketodihydrosphingosine reductase [KDSR] <12.68,9.38>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) KDSR //ceramide synthase [CerS] <12.68,14.33>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) CerS //ceramide synthase [CerS2] <12.68,29.22>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) CerS //dihydroceramide Δ4-desaturase [DES] <12.68,19.84>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) DES //UDP-glucose:ceramide glucosyltransferase [UGCG] <21.50,26.46>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) UGCG //Unknown Gene [Ugen] <24.81,35.84>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) ? //Unknown Gene [Ugen2] <63.95,39.69>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) ? //Unknown Gene [Ugen3] <38.33,19.95>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) ? //β-1,4-galactosyltransferase5 and 6 [B4GalT5] <39.38,37.80>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) B4GalT5 //β-1,4-galactosyltransferase5 and 6 [B4GalT5-2] <62.84,36.38>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) B4GalT5 //ST3β-galactoside α-2,3-sialyltransferase 5 [ST3GalT5] <56.23,34.18>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) ST3GalT5 //Sphingomyelin synthase 1 [SMS1] <42.00,22.05>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) SMS1 //Sphingomyelin synthase 2 [SMS2] <95.37,15.44>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) SMS2 //neutral SMase 2 [NSMase2] <53.55,21.53>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) NSMase 2 //neutral SMase 2 [NSMase1] <57.33,51.27>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) NSMase 1 //four-phosphate adaptor protein 2 [FAPP2] <24.81,45.76>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) transferred by FAPP2 r=(l_w3)=>d[GlcCer4] //α-1,4-galactosyltransferase [A4GalT] <62.30,31.97>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) A4GalT //β-1,4-N-acetylgalactosaminyltransferase 1 (GM2/GD2 synthase) [B4GalNT1] <72.5,39>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) B4GalNT1 //ceramide transfer protein [CERT] <33.08,15.23>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) transferred by CERT d=(l_w3)=>u[Cer2] r=(l_w3)=>l[Cer4] //ceramidekinase [CERK] <66.71,20.40>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) CERK //β-glucosidases 1 [GBA1] <81.59,13.23>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) GBA1 //β-glucosidases 2 [GBA2] <12.68,42.45>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) GBA2 //acidic SMase [ASMase] <98.12,23.15>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) ASMase //acidic SMase [ASMase2] <81.59,1.66>css(background:rgb(255,200,50;border:5px solid rgb(255,100,50;z-index:5) ASMase