View source for Category:LBS/Biosynthesis/CeramideSyn

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|style="background:darkseagreen;border-radius: 20px 0px 0px 0px" | serine<br/>+<br/>palmitoyl (16:0)-CoA
|style="background:darkseagreen" | <br/>[[File:Arrow00r.png]]<br/>&nbsp;<small>serine palmitoyl<br/>&nbsp; transferase</small>
|style="background:darkseagreen" | 3-ketodihydro-<br/>&nbsp; sphingosine<br/>(3-KDS)
|style="background:darkseagreen" | <br/>[[File:Arrow00r.png]]<br/>&nbsp; <small>3-KDS<br/>&nbsp; reductase</small>
|style="background:darkseagreen" | dihydrosphingosine<br/>(DHS, d18:0)
|style="background:darkseagreen" | <small>Cer synthase</small><br/>[[File:Arrow1rr.png]]<br/><small>fatty acyl CoA</small>
|style="background:darkseagreen" | dihydroceramide<br/>(DHCer)
|style="background:darkseagreen" | <br/>[[File:Arrow00r.png]]<br/>&nbsp; <small>DHCer<br/>&nbsp; desaturase</small>
|style="background:darkseagreen;border-radius: 0px 20px 0px 0px" | ceramide<br/>(Cer)
|-
|colspan="9" style="background:darkseagreen;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: white;"| <big>Cytosolic surface of the endoplasmic reticulum (ER)</big>
|}

{| class="wikitable collapsible collapsed" style="width: 100%"
!colspan="4"| Enzyme function in the Human Genome
|-
! Protein name
! Gene name (Uniprot)
! Location
!
|-
|rowspan="5"| Serine palmitoyl transferase (SPT)
| [http://www.uniprot.org/uniprot/O15269 SPTLC1]
|
|rowspan="5"| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.
<ul>
<li>SPTLC1-SPTLC2-SPTSSA ... C16-CoA
<li>SPTLC1-SPTLC3-SPTSSA ... C14- and C16-CoA
<li>SPTLC1-SPTLC2-SPTSSB ... C18-CoA
<li>SPTLC1-SPTLC3-SPTSSB ... broad specificity
</ul>
|-
| [http://www.uniprot.org/uniprot/O15270 SPTLC2]
| 
|-
| [http://www.uniprot.org/uniprot/Q9NUV7 SPTLC3]
|
|-
| [http://www.uniprot.org/uniprot/Q969W0 SPTSSA] (ssSPTa)
|
|-
| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB] (ssSPTb)
|
|-
|rowspan="1"| 3-Ketodihydrosphingosine reductase
|-
| [http://www.uniprot.org/uniprot/Q06136 KDSR]
| 
|-
|rowspan="6"| Ceramide synthase
| CerS1<br/>(LAG1 longevity assurance homolog 1)
| 19q12
| Brain, skeletal muscle, testis for C18
|-
| [http://www.uniprot.org/uniprot/Q96G23 CerS2]<br/>(Tumor metastasis-suppressor gene 1)
| 1q21.2
| Kidney, liver and other >12 organs for C20-C26
|-
| CerS3
| 15q26.3
| Skin, testis for C22-C26 α-hydroxy chains
|-
| CerS4
| 19q13.2
| Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver.
|-
| CerS5
| 12q13.3
| Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia.
|-
| CerS6
| 2q24.3
| Low in all tissues for C14-C16
|-
|rowspan="2"|Dihydroceramide &Delta;4-desaturase 
| DEGS1 (DES1)
| 1q42.11
|
|-
| DEGS2 (DES2)
|
| The enzyme hydroxylates DES to form phytoceramide.
|}