Category:LBS/Biosynthesis/GIPC: Difference between revisions

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{| style="text-align:center"
{| style="text-align:center" cellspacing="0"
|-
|-  
| palmitoyl (16:0)-CoA<br/>+<br/>serine
| style="background:darkseagreen;border-radius: 20px 0px 0px 20px" | palmitoyl (16:0)-CoA<br/>+<br/>serine
| SPT<br/>[[File:Arrow00r.png]]<br/>
| style="background:darkseagreen" | SPT<br/>[[File:Arrow00r.png]]<br/>
|3-keto sphinganine
| style="background:darkseagreen" |3-keto sphinganine
|KSR<br/>[[File:Arrow00r.png]]<br/>
| style="background:darkseagreen" |KSR<br/>[[File:Arrow00r.png]]<br/>
|sphinganine<br/>d18:0
| style="background:darkseagreen" |sphinganine<br/>d18:0
| LCB C-4 OHase<br/>[[File:Arrow00r.png]]
| style="background:darkseagreen" | LCB C-4 OHase<br/>[[File:Arrow00r.png]]
|phytosphinganine<br/>t18:0
| style="background:darkseagreen;border-radius: 0px 20px 0px 0px" |phytosphinganine<br/>t18:0
|
|
|-
|-
| colspan="4" style="background:darkseagreen;border-radius: 40px"| Lumen of endoplasmic reticulum (ER)
| colspan="4"|
| {{Map/ReactionDown|16:0-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1–15.</ref>}}
| style="background:darkseagreen" | {{Map/ReactionDown|16:0-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1?15.</ref>}}
| rowspan="4" style="background:darkseagreen;border-radius: 40px"| Lumen of endoplasmic reticulum (ER)
| rowspan="4" style="background:darkseagreen; font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Lumen of endoplasmic reticulum (ER)
| {{Map/ReactionDown|VLCFA-CoA||CS II}}
| style="background:darkseagreen" | {{Map/ReactionDown|VLCFA-CoA||CS II}}
|
|
|-
|-
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|'''Abbreviations'''<br/>SPT: serine palmitoyltransferase<br/>KSR: 3-ketosphinganine reductase<br/>LCB: long-chain base<br/>GCS: glucosylceramide synthase<br/>CS I/II: (dihydro)ceramide synthase I/II<br/>DES: desaturase<br/>FA OHase: Fatty-acid hydroxylase<br/>MT: methyltransferase<br/>VLCFA: very long-chain fatty acid<br/>IPCS: inositol phosphoceramide synthase<br/>PI: phosphatidylinositol<br/>DAG: diacylglycerol
|'''Abbreviations'''<br/>SPT: serine palmitoyltransferase<br/>KSR: 3-ketosphinganine reductase<br/>LCB: long-chain base<br/>GCS: glucosylceramide synthase<br/>CS I/II: (dihydro)ceramide synthase I/II<br/>DES: desaturase<br/>FA OHase: Fatty-acid hydroxylase<br/>MT: methyltransferase<br/>VLCFA: very long-chain fatty acid<br/>IPCS: inositol phosphoceramide synthase<br/>PI: phosphatidylinositol<br/>DAG: diacylglycerol
|}
|}
| '''d18:0-16:0'''
| style="background:darkseagreen" | '''d18:0-16:0'''
| '''t18:0-VLCFA'''
| style="background:darkseagreen" | '''t18:0-VLCFA'''
|
|
|-
|-
| {{Map/ReactionDown|||&Delta;8 DES<br/>&Delta;4 DES<br/>FA-&alpha;OHase<br/>(C-9 MT in fungi)}}
| style="background:darkseagreen" | {{Map/ReactionDown|||&Delta;8 DES<br/>&Delta;4 DES<br/>FA-&alpha;OHase<br/>(C-9 MT in fungi)}}
| {{Map/ReactionDown|||&Delta;8 DES<br/>FA-&alpha;OHase}}
| style="background:darkseagreen" | {{Map/ReactionDown|||&Delta;8 DES<br/>FA-&alpha;OHase}}
| '''Bold font = ceramides'''
| '''Bold font = ceramides'''
|-
|-
| '''d18:1&Delta;8E/Z-h16:0'''
| style="background:darkseagreen" | '''d18:1&Delta;8E/Z-h16:0'''
| ''' t18:1&Delta;8E/Z-hVLCFA'''
| style="background:darkseagreen" | ''' t18:1&Delta;8E/Z-hVLCFA'''
|
|
|-
|-
| [[File:Arrow00dr35.png]] <small>+UDP-Glc</small>
| style="background:darkseagreen;border-radius: 0px 0px 0px 20px" | [[File:Arrow00dr35.png]] <small>+UDP-Glc</small>
| <small>+UDP-Glc</small> [[File:Arrow00dl35.png]]
| style="background:darkseagreen" | <small>+UDP-Glc</small> [[File:Arrow00dl35.png]]
| style="text-align:right;"| ''transport'' [[File:Arrow00dr35.png]]
| style="text-align:right;background:darkseagreen;border-radius: 0px 0px 20px 0px"| ''transport'' [[File:Arrow00dr35.png]]
|
|
|-  
|-  
|colspan="2" rowspan="3" valign="top"| '''Glc-ceramide'''<br/>Glc-d18:2 4E,8E/Z-h16:0<br/>Glc-d18:1 8E/Z-h16:0<br/>Glc-t18:1-hVLCFA
|colspan="2" rowspan="3" valign="top"| '''Glc-ceramide'''<br/>Glc-d18:2 4E,8E/Z-h16:0<br/>Glc-d18:1 8E/Z-h16:0<br/>Glc-t18:1-hVLCFA
|rowspan="3" style="background:darkturquoise;border-radius: 40px"| Golgi
|rowspan="3" style="background:darkturquoise;border-radius: 20px 0px 0px 20px;font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Golgi
| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>(in Golgi)
| style="background:darkturquoise;border-radius: 0px 20px 0px 0px"| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>(in Golgi)
|-  
|-  
| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219–226</ref>}}
| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219?226</ref>}}
|-
|-
| '''GIPC''' (in Golgi)
| style="background:darkturquoise;border-radius: 0px 0px 20px 0px"| '''GIPC''' (in Golgi)
|}
|}


<references/>
<references/>

Revision as of 05:55, 10 April 2016

palmitoyl (16:0)-CoA
+
serine 		SPT
Arrow00r.png
 3-keto sphinganine KSR
Arrow00r.png
 sphinganine
d18:0 		LCB C-4 OHase
Arrow00r.png 		phytosphinganine
t18:0
Arrow1ld35.png
16:0-CoA
CS I[1]
Lumen of endoplasmic reticulum (ER)
Arrow1ld35.png
VLCFA-CoA
CS II
Abbreviations
SPT: serine palmitoyltransferase
KSR: 3-ketosphinganine reductase
LCB: long-chain base
GCS: glucosylceramide synthase
CS I/II: (dihydro)ceramide synthase I/II
DES: desaturase
FA OHase: Fatty-acid hydroxylase
MT: methyltransferase
VLCFA: very long-chain fatty acid
IPCS: inositol phosphoceramide synthase
PI: phosphatidylinositol
DAG: diacylglycerol
d18:0-16:0 t18:0-VLCFA
Arrow00d35.png
Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)
Arrow00d35.png
Δ8 DES
FA-αOHase
Bold font = ceramides
d18:1Δ8E/Z-h16:0 t18:1Δ8E/Z-hVLCFA
Arrow00dr35.png +UDP-Glc +UDP-Glc Arrow00dl35.png transport Arrow00dr35.png
Glc-ceramide
Glc-d18:2 4E,8E/Z-h16:0
Glc-d18:1 8E/Z-h16:0
Glc-t18:1-hVLCFA 		Golgi t18:1Δ8E/Z-hVLCFA
(in Golgi)
Arrow3ld.png
PI
IPCS[2]
DAG
GIPC (in Golgi)
  1. ↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1?15.
  2. ↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219?226

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