Category:LBS/Biosynthesis/GIPC

palmitoyl (16:0)-CoA
+
serine 		SPT
Arrow00r.png
 3-keto sphinganine KSR
Arrow00r.png
 sphinganine
d18:0 		LCB C-4 OHase
Arrow00r.png 		phytosphinganine
t18:0
Arrow1ld35.png
LCFA-CoA
CS I[1]
Lumen of endoplasmic
reticulum (ER)
Arrow1ld35.png
VLCFA-CoA
CS II
Abbreviations
CS I/II (dihydro)ceramide synthase I/II
DAG diacylglycerol
DES desaturase
FA OHase Fatty-acid hydroxylase
GCS glucosylceramide synthase
IPCS inositol phosphoceramide synthase
KSR 3-ketosphinganine reductase
LCB long-chain base
LCFA long-chain fatty acid
MT methyltransferase
PI phosphatidylinositol
SPT serine palmitoyltransferase
VLCFA very long-chain fatty acid
d18:0-LCFA t18:0-VLCFA
Arrow00d35.png
Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)
Arrow00d35.png
Δ8 DES
FA-αOHase
Bold font = ceramides
d18:1Δ8E/Z-hLCFA t18:1Δ8E/Z-hVLCFA
Arrow00dr35.png +UDP-Glc +UDP-Glc Arrow00dl35.png transport Arrow00dr35.png
Glc-ceramide
Glc-d18:2 4E,8E/Z-hLCFA
Glc-d18:1 8E/Z-hLCFA
Glc-t18:1-hVLCFA 		Golgi t18:1Δ8E/Z-hVLCFA
Arrow3ld.png
PI
IPCS[2]
DAG
GIPC
  1. ↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146
  2. ↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304

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