Revision as of 06:50, 3 July 2009

Ether Phospholipid Biosynthesis

エーテルリン脂質の生合成

dihydroxy acetone p

R1-CO-CoA

CoA

NADH NAD+

sn-glycerol 3p

R1-CO-CoA

CoA

1-acyl dihydroxy acetone p

NADH NAD+

1-acyl sn-glycerol 3p>File:1CSG3P.png

R1-OH

→R-COOH

1-alkyl dihydroxy acetone p^[1]

NADPH

→NADP+

1-alkyl sn-glycerol 3p
File:1KSG3P.png

R2-CO-CoA

CoA

1-acyl sn-glycerol 3p
or lyso-phosphatidate
>

R2-CO-CoA

CoA

1-alkyl 2-acyl sn-glycerol 3p
File:1K2CSG3P.png

H2O

Pi

1,2-diacyl sn-glycerol 3p
or phosphatidate

H2O

Pi

1-alkyl 2-acyl sn-glycerol

CDP-choline

platelet-activating factor (PAF; 2=acetyl)
or plasmalogen^[2]

1,2-diacyl and triacyl sn-glycerol

@@ Line 11: / Line 11: @@
 |style="text-align:center;"|1-acyl dihydroxy acetone p
 |{{Map/ReactionLeftRight|NADH|NAD+|[http://metabolomics.jp/wiki/Enzyme:1.1.1.8 1.1.1.8]}}
-|style="text-align:center;"|1-acyl ''sn''-glycerol 3p
+|style="text-align:center;"|1-acyl ''sn''-glycerol 3p>[[Image:1CSG3P.png]]
 |-
 |{{Map/ReactionDown35inout|R1-OH|<small>&rarr;R-COOH</small>|}}1-alkyl dihydroxy acetone p<ref>アルキル型を含むエーテルリン脂質はペルオキシソームで合成。ペルオキシソームを欠乏するZellweger症候群では血小板活性化因子PAFが著しく減少。</ref>{{Map/ReactionDown35inout|NADPH|<small>&rarr;NADP+</small>|}}
@@ Line 20: / Line 20: @@
 {{Map/ReactionDown|R2-CO-CoA|CoA|[http://metabolomics.jp/wiki/Enzyme:2.3.1.51 2.3.1.51]}}
 |
-|style="text-align:center;"|1-acyl ''sn''-glycerol 3p<br/>or lyso-phosphatidate<br/>[[Image:1CSG3P.png]]
+|style="text-align:center;"|1-acyl ''sn''-glycerol 3p<br/>or lyso-phosphatidate<br/>>
 {{Map/ReactionDown|R2-CO-CoA|CoA|[http://metabolomics.jp/wiki/Enzyme:2.3.1.51 2.3.1.51]}}
 |-