Template:Map/Phospholipid degradation: Difference between revisions
 
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=Phospholipid degradation=
=Phospholipid degradation=
リン脂質の分解
リン脂質の分解
{{Map/Instruction}}


{|style="text-align:center;"
{|style="text-align:center;"
|-
|-
|diacyl glycerol<br/>[[Image:LBDG.png]]
|{{Map/MetaboliteSink|PL biosynthesis|Map/Glycerophospholipid}}<br/>diacyl glycerol (DG) <br/>[[Image:LBDG.png]]
|phospholipase C<br/>{{Map/ReactionLeft|P-choline|H2O|3.1.4.3}}
|phospholipase C<ref>細菌由来のホスホリパーゼCは菌体外に毒素とともに排出され様々な基質特異性を持つ。動物細胞のものはホスファチジルイノシトールの代謝回転に関与。</ref><br/>{{Map/ReactionLeft|P-choline|H2O|3.1.4.3}}
|phosphatidyl choline<br/>[[Image:LBGPC.png]]
|{{Map/MetaboliteSource|phosphatidyl choline}} (PC)<br/>[[Image:LBGPC.png]]
|phospholipase D<br/>{{Map/ReactionRight|H2O|choline|3.1.4.4}}
|phospholipase D<ref>ホスホリパーゼDは高等植物、動物に広く存在する。カルジオリピン特異的なものは細菌中に存在。</ref><br/>{{Map/ReactionRight|H2O|choline|3.1.4.4}}
|phosphatidate<br/>[[Image:LBGPA.png]]
|{{Map/MetaboliteSink|PL biosynthesis|Map/Glycerophospholipid}}<br/>phosphatidate (PA)<br/>[[Image:LBGPA.png]]
|-
|-
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|colspan="3"|
|
{| style="margin:auto;text-align:center;"
{| style="margin:auto;text-align:center;"
|-
|-
|[[Image:Arrow1rdl.png]]
|Phospholipase A1<ref name="pla">ホスホリパーゼA1,A2は膜結合性だが、高等生物のA2は細胞質、細胞外に属するものも存在する。</ref>
|[[Image:Arrow1ldr.png]]
|{{Map/ReactionLeftDown|H2O|R1-COOH|3.1.1.32}}
|{{Map/ReactionRightDown|H2O|R2-COOH|3.1.1.4}}
|Phospholipase A2<ref name="pla"/>
|-
|colspan="2"|2-acyl lyso-PC
|colspan="2"|1-acyl lyso-PC
|-
|-
|2-acyl lyso-PC<br/>[[Image:Arrow3rdr.png]]
|colspan="4"|
|1-acyl lyso-PC<br/>[[Image:Arrow3ldl.png]]
{| style="margin:auto;"
|{{Map/ReactionRightDown|H2O|R2-COOH|3.1.1.5}}
|Lysophospholipase
|{{Map/ReactionLeftDown|H2O|R1-COOH|3.1.1.5}}
|}
|}
|}
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|style="text-align:center;"|''sn''-glycerol 3p<br/>
|style="text-align:center;"|''sn''-glycerol 3p<br/>
|}
|}
<references/>


=Sphingomyelin degradation=
=Sphingomyelin degradation=
{| style="text-align:center;"
|-
| sphingomyelin<br/>[[LBSM.png]]
| {{Map/ReactionRight|H2O|p-choline|3.1.4.-}}
| ceramide<br/>(''N''-acyl sphingosine)<br/>[[LBSC.png]]
| {{Map/ReactionRight|H2O|RCOOH|3.5.1.23}}
| sphingosine<br/>''trans''-4-sphingenine<br/>[[LBS.png]]
|-
|
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| {{Map/ReactionDown|ATP|ADP|}}
|-
|
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| palmital<br/>
| {{Map/ReactionLeft|p-ethanolamine|H2O|}}
| sphingenine 1-phosphate<br/>[[LBSP.png]]
|}

Latest revision as of 02:41, 1 August 2009

Phospholipid degradation

リン脂質の分解

   ... central metabolite
   ... other maps
¤PL biosynthesis
diacyl glycerol (DG)
LBDG.png 		phospholipase C[1]
3.1.4.3
Arrow3ll.png
P-choline   H2O 		phosphatidyl choline (PC)
LBGPC.png 		phospholipase D[2]
3.1.4.4
Arrow3rr.png
H2O   choline 		¤PL biosynthesis
phosphatidate (PA)
LBGPA.png
Phospholipase A1[3]
Arrow3ldl.png H2O
3.1.1.32
R1-COOH
H2O
3.1.1.4
R2-COOH 		Arrow3rdr.png
Phospholipase A2[3]
2-acyl lyso-PC 1-acyl lyso-PC
H2O
3.1.1.5
R2-COOH 		Arrow3rdr.png
Lysophospholipase
Arrow3ldl.png H2O
3.1.1.5
R1-COOH
sn-glycerol 3-phosphocholine 3.1.4.2
Arrow3rr.png
H2O   choline 		sn-glycerol 3p
  1. ↑ 細菌由来のホスホリパーゼCは菌体外に毒素とともに排出され様々な基質特異性を持つ。動物細胞のものはホスファチジルイノシトールの代謝回転に関与。
  2. ↑ ホスホリパーゼDは高等植物、動物に広く存在する。カルジオリピン特異的なものは細菌中に存在。
  3. ↑ 3.0 3.1 ホスホリパーゼA1,A2は膜結合性だが、高等生物のA2は細胞質、細胞外に属するものも存在する。

Sphingomyelin degradation

sphingomyelin
LBSM.png 		3.1.4.-
Arrow3rr.png
H2O   p-choline 		ceramide
(N-acyl sphingosine)
LBSC.png 		3.5.1.23
Arrow3rr.png
H2O   RCOOH 		sphingosine
trans-4-sphingenine
LBS.png
Arrow3ld.png
ATP
ADP
palmital
Arrow3ll.png
p-ethanolamine   H2O 		sphingenine 1-phosphate
LBSP.png
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