Category:LBS/Biosynthesis/CeramideSyn: Difference between revisions

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!colspan="4"| Enzyme function in the Human Genome
!colspan="4"| Enzyme function in the Human Genome
|-
|-
! Name
! Protein name
! Human gene
! Gene name (Uniprot)
! Location
! Location
!
!
Line 72: Line 72:
| Low in all tissues for C14-C16
| Low in all tissues for C14-C16
|-
|-
|rowspan="2"|dihydroceramide Δ4-desaturase  
|rowspan="2"|Dihydroceramide Δ4-desaturase  
| DES1
| DEGS1 (DES1)
|  
| 1q42.11
|
|
|-
|-
| DES2
| DEGS2 (DES2)
|
|
| The enzyme hydroxylates DES to form phytoceramide.
| The enzyme hydroxylates DES to form phytoceramide.
|}
|}

Revision as of 07:48, 18 December 2017

serine
+
palmitoyl (16:0)-CoA

 serine palmitoyl
  transferase 		3-ketodihydro-
  sphingosine
(3-KDS)

  3-KDS
  reductase 		dihydrosphingosine
(DHS, d18:0) 		Cer synthase

fatty acyl CoA 		dihydroceramide
(DHCer)

  DHCer
  desaturase 		ceramide
(Cer)
Cytosolic surface of the endoplasmic reticulum (ER)

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