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| |style="background:AntiqueWhite;border-radius: 0px 20px 0px 0px" | palmitate | | |style="background:AntiqueWhite;border-radius: 0px 20px 0px 0px" | palmitate |
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| |colspan="11" style="background:AntiqueWhite;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: black;"| <big>Cytosol</big> | | |colspan="11" style="background:AntiqueWhite;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: black;"| <big>ER, Golgi and Lysosomes</big> |
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Revision as of 09:12, 18 December 2017
| ceramide
|
ceramidase
fatty acid
|
sphingosine
|
S1P phosphatase
|
sphingosine
1-phosphate
|
S1P lyase
phosphoethanolamine
|
hexadecenal
|
|
hexadecanal
|
|
palmitate
|
| ER, Golgi and Lysosomes
|
| [show]Enzyme function in the Human Genome
|
| Protein name
|
Gene name (Uniprot)
|
Location
|
|
| Acid ceramidase
|
ASAH1
|
|
Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).[1]
|
| Neutral ceramidase
|
ASAH2
|
|
Localized to the plasma membrane and expressed in the small intestine and colon. [2]
|
| Alkaline ceramidase
|
ACER1
|
|
Localized to the endoplasmic reticulum (ER) and highly expressed in skin.
|
| ACER2
|
|
Localized to the Golgi complex and highly expressed in placenta.
|
| ACER3
|
|
Localized to the ER and the Golgi complex, and ubiquitously expressed.
|
| S1P phosphatase
|
SGPP1
|
|
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P.
|
| SGPP2
|
|
Localized to the ER and dephosphorylates S1P and dihydro-S1P.[3]
|
| S1P lyase
|
SGPL1
|
|
|
- ↑ Ferlinz K, Kopal G, Bernardo K et al. (2001) "Human acid ceramidase: processing, glycosylation, and lysosomal targeting" J Biol Chem 276(38):35352-35360.
- ↑ Coant N, Sakamoto W, Mao C, Hannun YA (2015) "Ceramidases, roles in sphingolipid metabolism and in health and disease" Adv Biol Regul 63:122-131
- ↑ Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003) "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2" J Biol Chem 278(2):1268-1272.
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