Category:LBS/Biosynthesis/CeramideDeg: Difference between revisions
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|colspan="11" style="background:AntiqueWhite;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: black;"| <big>Cytosol</big> | |colspan="11" style="background:AntiqueWhite;border-radius: 0px 0px 20px 20px; font-weight: 600; text-shadow:black 3px 3px 5px; color: black;"| <big>Cytosol</big> | ||
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!colspan="4"| Enzyme function in the Human Genome | |||
|- | |||
! Protein name | |||
! Gene name (Uniprot) | |||
! Location | |||
! | |||
|- | |||
| Acid ceramidase | |||
| ASAH1 | |||
| | |||
| Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).<ref>Ferlinz K, Kopal G, Bernardo K et al. (2001) "Human acid ceramidase: processing, glycosylation, and lysosomal targeting" J Biol Chem 276(38):35352-35360.</ref> | |||
|- | |||
| Neutral ceramidase | |||
| ASAH2 | |||
| | |||
| Localized to the plasma membrane and expressed in the small intestine and colon. <ref>Coant N, Sakamoto W, Mao C, Hannun YA (2015) "Ceramidases, roles in sphingolipid metabolism and in health and disease" Adv Biol Regul 63:122-131</ref> | |||
|- | |||
|rowspan="3"| Alkaline ceramidase | |||
| ACER1 | |||
| | |||
| Localized to the endoplasmic reticulum (ER) and highly expressed in skin. | |||
|- | |||
| ACER2 | |||
| | |||
| Localized to the Golgi complex and highly expressed in placenta. | |||
|- | |||
| ACER3 | |||
| | |||
| Localized to the ER and the Golgi complex, and ubiquitously expressed. | |||
|- | |||
| rowspan="2"| S1P phosphatase | |||
| SGPP1 | |||
| | |||
| Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. | |||
|- | |||
| SGPP2 | |||
| | |||
| Localized to the ER and dephosphorylates S1P and dihydro-S1P.<ref>Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003) "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2" J Biol Chem 278(2):1268-1272.</ref> | |||
|- | |||
| S1P lyase | |||
| SGPL1 | |||
| | |||
| | |||
|- | |||
|colspan="4"|<references/> | |||
|} | |} | ||
Revision as of 00:11, 18 December 2017
| ceramide | ceramidase fatty acid |
sphingosine | S1P phosphatase |
sphingosine 1-phosphate |
S1P lyase phosphoethanolamine |
hexadecenal |  |
hexadecanal | |
palmitate |
| Cytosol | ||||||||||
| Enzyme function in the Human Genome | |||
|---|---|---|---|
| Protein name | Gene name (Uniprot) | Location | |
| Acid ceramidase | ASAH1 | Localized in lysosome. Its deficiency causes lysosomal accumulation of ceramides (Farber disease).[1] | |
| Neutral ceramidase | ASAH2 | Localized to the plasma membrane and expressed in the small intestine and colon. [2] | |
| Alkaline ceramidase | ACER1 | Localized to the endoplasmic reticulum (ER) and highly expressed in skin. | |
| ACER2 | Localized to the Golgi complex and highly expressed in placenta. | ||
| ACER3 | Localized to the ER and the Golgi complex, and ubiquitously expressed. | ||
| S1P phosphatase | SGPP1 | Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. | |
| SGPP2 | Localized to the ER and dephosphorylates S1P and dihydro-S1P.[3] | ||
| S1P lyase | SGPL1 | ||
| |||
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