Category:LBS/Biosynthesis/CeramideSyn: Difference between revisions
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|rowspan="4"| Serine palmitoyl transferase (SPT) | |rowspan="4"| Serine palmitoyl transferase (SPT) | ||
| [http://www.uniprot.org/uniprot/O15269 SPTLC1] (SPT/LCB1-3) | | [http://www.uniprot.org/uniprot/O15269 SPTLC1]<br> (SPT/LCB1-3) | ||
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|rowspan="4"| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (ssSPTa or ssSPTb) are essential for the full enzymatic activity. | |rowspan="4"| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (ssSPTa or ssSPTb) are essential for the full enzymatic activity. | ||
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| Brain, skeletal muscle, testis for C18 | | Brain, skeletal muscle, testis for C18 | ||
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| [http://www.uniprot.org/uniprot/Q96G23 CerS2]<br | | [http://www.uniprot.org/uniprot/Q96G23 CerS2]<br>(Tumor metastasis-suppressor gene 1) | ||
| 1q21.2 | | 1q21.2 | ||
| Kidney, liver and other >12 organs for C20-C26 | | Kidney, liver and other >12 organs for C20-C26 | ||
Revision as of 09:45, 18 December 2017
| serine + palmitoyl (16:0)-CoA |
 serine palmitoyl transferase |
3-ketodihydro- sphingosine (3-KDS) |
3-KDS reductase |
dihydrosphingosine (DHS, d18:0) |
Cer synthase fatty acyl CoA |
dihydroceramide (DHCer) |
DHCer desaturase |
ceramide (Cer) |
| Cytosolic surface of the endoplasmic reticulum (ER) | ||||||||
| [show]Enzyme function in the Human Genome |
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