Category:LBS/Biosynthesis/CeramideSyn: Difference between revisions
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| [http://www.uniprot.org/uniprot/O15269 SPTLC1] | | [http://www.uniprot.org/uniprot/O15269 SPTLC1] | ||
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|rowspan="5"| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits ( | |rowspan="5"| A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity. | ||
<ul> | <ul> | ||
<li>SPTLC1-SPTLC2- | <li>SPTLC1-SPTLC2-SPTSSA ... C16-CoA | ||
<li>SPTLC1-SPTLC3- | <li>SPTLC1-SPTLC3-SPTSSA ... C14- and C16-CoA | ||
<li>SPTLC1-SPTLC2- | <li>SPTLC1-SPTLC2-SPTSSB ... C18-CoA | ||
<li>SPTLC1-SPTLC3- | <li>SPTLC1-SPTLC3-SPTSSB ... broad specificity | ||
</ul> | </ul> | ||
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Revision as of 10:38, 18 December 2017
| serine + palmitoyl (16:0)-CoA |
 serine palmitoyl transferase |
3-ketodihydro- sphingosine (3-KDS) |
3-KDS reductase |
dihydrosphingosine (DHS, d18:0) |
Cer synthase fatty acyl CoA |
dihydroceramide (DHCer) |
DHCer desaturase |
ceramide (Cer) |
| Cytosolic surface of the endoplasmic reticulum (ER) | ||||||||
| [show]Enzyme function in the Human Genome |
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